대한한의학회지 (The Journal of Korean Medicine)

  • 제26권3호
  • /
  • Pages.98-109
  • /
  • 2005
  • /
  • 1010-0695(pISSN)
  • /
  • 2288-3339(eISSN)
대한한의학회 (The Society of Korean Medicine)
권호 표지

Streptococcus Pneumoniae에 대한 단삼의 생육 억제 효과

Effective Antibacterial Activity of Salvia Miltiorrhiza against Streptococcus Pneumoniae ATCC 33400

  • 박재훈 (동국대학교 분당한방병원) ;
  • 정운석 (동국대학교 분당한방병원) ;
  • 이주일 (동국대학교 분당한방병원) ;
  • 서운교 (동국대학교 분당한방병원)
  • Park Jae-Hun (Department of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Jung Wun-Suk (Department of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Lee Ju-Il (Department of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Seo Un-Kyo (Department of Internal Medicine, College of Oriental Medicine, Dongguk University)
  • 발행 : 2005.09.01
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초록

Objectives : This study was designed to identify the effects of Salvia Miltiorrhiza or antibacterial activity against Streptococcus pneumoniae ATCC 33400. Methods : The ethanol- and water-extracts of more than 80 oriental herbal medicines were investigated by the Kirby-Bauer method to determine their inhibitory effect on growth of S. pneumoniae ATCC 33400 in vitro. Of thorn, Salvia Miltiorrhiza was selected. Results : The ethanol-soluble extract of Salvia Miltiorrhiza showed relatively high antibacterial activity against S. pneumoniae ATCC 33400. However, the water-soluble extract of Salvia Miltionrhiza showed no antibacterial activity. The ethanolic extract was forker fractionated with organic solvents such as hexane, chloroform, and ethyl acetate in that order. Among the fraction tested, the chloroform fraction showed the highest antibacterial activity, when the ethanol-soluble extract of Salvia Miltiorrhiza minimal inhibitory concentration (MIC) was 25${\mu}g/ml$. Conclusions : Further study should be carried out to identity of the cell growth inhibition effects of S. pneumoniae ATCC 33400.

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