Journal of Powder Materials (한국분말재료학회지)

The Korean Powder Metallurgy & Materials Institute (한국분말재료학회 (*구 분말야금학회))
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The study of Synthesis of Dihydropyrimidine for Cardiotropic Drugs Using New Catalysts on the Basis of Nano Cu Oxides

신촉매 나노 구리산화물을 이용한 심혈관 의약품용 Dihydropyrimidine 제조 연구

  • Uhm Y. R. (Nuclear Nano Materials Development LAB., Korea Atomic Energy Research Institute(KAERI)) ;
  • Lee M. K. (Nuclear Nano Materials Development LAB., Korea Atomic Energy Research Institute(KAERI)) ;
  • Rhee C. K. (Nuclear Nano Materials Development LAB., Korea Atomic Energy Research Institute(KAERI))
  • 엄영랑 (한국원자력연구소 원자려나노소재응용 LAB.) ;
  • 이민구 (한국원자력연구소 원자려나노소재응용 LAB.) ;
  • 이창규 (한국원자력연구소 원자려나노소재응용 LAB.)
  • Published : 2005.12.01
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Abstract

The copper oxide nano powders were synthesized by levitational gas condensation (LGC) method, and were applied to catalyst to fabricate 3,4-dihydropyrimidin-2-(1H)-one. Processes of adsorption of Biginelli reaction reagents on the copper nanooxide surface $Cu_2O{\circ}CuO$ were studied by IR-spectroscopy. It was shown that benzaldehyde coordination, acetoacetic ether on the oxide surface is carried out with participation of carbonyl fragments, urea by N-H bonds which affects positively on the reagents reactivity.

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References

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