Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Acute Rejection after Renal Allograft in a Dog

개의 신장 동종이식 후 발생된 급성 거부반응

  • Nam Hyun sook (Department of Veterinary Medicine and Institute of Veterinary Sciences, Kangwon National University) ;
  • Uhm Ji Yong (Department of Veterinary Medicine and Institute of Veterinary Sciences, Kangwon National University) ;
  • Yoon Byung IL (Department of Veterinary Medicine and Institute of Veterinary Sciences, Kangwon National University) ;
  • Woo Heung Myung (Department of Veterinary Medicine and Institute of Veterinary Sciences, Kangwon National University)
  • 남현숙 (강원대학교 수의학과 동물의학연구소) ;
  • 엄지용 (강원대학교 수의학과 동물의학연구소) ;
  • 윤병일 (강원대학교 수의학과 동물의학연구소) ;
  • 우흥명 (강원대학교 수의학과 동물의학연구소)
  • Published : 2005.12.01
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Abstract

Rejection is one of the life-threatening complications after organ transplantation. An eight-month-old, intact male, mixed breed dog was presented with acute rejection after renal allograft. The heterotopic renal transplantation with bilateral nephrectomy was performed in the dog. The triple drug protocol for immunosuppression was applied for prevention of the acute rejection. Postoperative care was done according to the transplantation protocol of VMTH, Kangwon National University. The dog was euthanized when the serum creatinine concentration exceeded 5 mg/dL followed by tile signs of illness. The transplanted kidney was enlarged. The renal cortex lesions were characterized by necrosis of the renal tubules and the glomeruli. Interstitial lesions were characterized by hemorrhage and severe infiltration of lymphoid cells. Intrarenal arteries showed necrosis of the walls and infiltration of perivascular lymphoid cells. In immunohistochemical (IHC) findings, infiltration of the CD4 and the CD8 positive T lymphocytes was examined. In this case, acute rejection was shown by humoral and cellular immunity on the basis of histopathologic and IHC evaluation.

Keywords

References

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