Preventive Nutrition and Food Science

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Effects of Fucoidan on NO Production and Phagocytosis of Macrophages and the Proliferation of Neuron Cells

  • Hang, Do (College of Pharmacy, Sungkyunkwan University) ;
  • Choi, Hye-Sook (College of Pharmacy, Sungkyunkwan University) ;
  • Kang, Se-Chan (College of Pharmacy, Sungkyunkwan University) ;
  • Kim, Kyung-Ran (College of Pharmacy, Sungkyunkwan University) ;
  • Sohn, Eun-Soo (Department of Technology Information Analysis, KISTI) ;
  • Kim, Mi-Hyun (Department of Food & Nutrition, Samcheok National University) ;
  • Pyo, Suhkneung (College of Pharmacy, Sungkyunkwan University) ;
  • Son, Eun-Wha (Department of Pharmacognosy Material Development, Samcheok National University)
  • Published : 2005.12.01
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Abstract

Fucoidans, high-molecular-weight sulfated polysaccharides extracted from brown seaweeds, have various biological activities. Here we examined whether fucoidan could ncrease the immunomodulation and proliferation capacity of cells in vitro. When peritoneal macrophages were treated with various concentrations of fucoidan $(1\~100{\mu}g/mL)$ for 24 hours, NO production was significantly increased. In addition, exposure of macrophages to $10{\mu}g/mL$ of fucoidan induced a phagocytic activity. Treatment of neuroblastoma cells (SK-N-SH) with fucoidan enhanced cell proliferation and NO production in a concentration-dependent manner. These results indicate that fucoidan has both immunomodulatory and cell proliferative properties, and may thus be a candidate for development as an immunomodulating agent.

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References

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