References
- Jobses, I., D. Martens, and J. Tramper (1991) Lethal events during gas sparging in animal cell culture. Biotechnol. Bioeng. 37: 484-490 https://doi.org/10.1002/bit.260370510
- Handa-Corrigan, A., A. N. Emery, and R. E. Spier (1989) Effect of gas-liquid interfaces on the growth of suspended mammalian-cells-mechanisms of cell-damage by bubbles. Enzyme Microb. Technol. 11: 230-235 https://doi.org/10.1016/0141-0229(89)90097-5
- Kioukia, N., A. W. Nienow, M. Al-Rubeai, and A. N. Emery (1996) Influence of agitation and sparging on the growth rate and infection of insect cells in bioreactors and a comparison with hybridoma culture. Biotechnol. Prog. 12: 779-785 https://doi.org/10.1021/bp9600703
- Kunas, K. T. and E. T. Papoutsakis (1990) Damage mechanisms of suspended animal-cells in agitated bioreactors without bubble entrainment. Biotechnol. Bioeng. 36:476-483 https://doi.org/10.1002/bit.260360507
- Papoutsakis, E. T. and K. T. Kunas (1989) Hydrodynamic effects of cultured hybridoma cells CRL 8018 in an agitated bioreactor. pp. 203-211. In: R. E. Spier, J. B. Griffiths, J. Stephenne, and P. J. Crooy, (eds.). Advances in Animal Cell Biology and Technology for Bioprocesses. Butterworths, Kent, UK
- Al-Rubeai, M., R. P. Singh, M. H. Goldman, and A. N. Emery (1995) Death mechanisms of animal-cells in conditions of intensive agitation. Biotechnol. Bioeng. 45: 463- 472 https://doi.org/10.1002/bit.260450602
- Shive, M. S., M. L. Salloum, and J. M. Anderson (2000) Shear stress-induced apoptosis of adherent neutrophils: A mechanism for persistence of cardiovascular device infections. Proc. Nat. Acad. Sci. 97: 6710-6715
- Dimmeler, S., J. Haendeler, V. Rippmann, M. Nehls, and A. M. Zeiher (1996) Shear stress inhibits apoptosis of human endothelial cells. FEBS Lett. 399: 71-74 https://doi.org/10.1016/S0014-5793(96)01289-6
- Hu, Y.-L., S. Li, J. Y. Shyy, and S. Chien (1999) Sustained JNK activation induces endothelial apoptosis: studies with colchicine and shear stress. Am. J. Physiol. 277: 1593-1599
- Kempken, R., H. Buntemeyer, and J. Lehmann (1991) The medium cycle bioreactor (MCB): monoclonal antibody production in a new economic production system. Cytotechnology 7: 63-74
- Mizrahi, A. and A. Avihoo (1977) Growth medium utilization and its re-use for animal cell cultures. J. Biol. Stand. 5: 31-37 https://doi.org/10.1016/0092-1157(77)90016-6
- Riese, U., D. Lutkemeyer, R. Heidermann, H. Buntemeyer, and J. Lehmann (1994) Reuse of spent cell-culture medium in pilot-scale and rapid preparative purification with membrane chromatography. J. Biotechnol. 34: 247-257 https://doi.org/10.1016/0168-1656(94)90060-4
- Dutton, R. L., J. M. Scharer, and M. Moo-Young (1999) Hybridoma growth and productivity: effects of conditioned medium and of inoculum size. Cytotechnology 29: 1-10 https://doi.org/10.1023/A:1008060802286
- Rein, A. and H. Rubin (1968) Effects of local cell concentrations upon the growth of chick embryo cells in tissue culture. Exp. Cell Res. 49: 666-678 https://doi.org/10.1016/0014-4827(68)90213-9
- Rubin, H. (1966) A substance in conditioned medium which enhances the growth of small numbers of chick embryo cells. Exp. Cell Res. 41: 138-148 https://doi.org/10.1016/0014-4827(66)90554-4
- Lee, G. M., T. K. Huard, and B. O. Palsson (1989) Effect of serum concentration on hybridoma cell growth and monoclonal antibody production at various initial cell densities. Hybridoma 8: 369-375 https://doi.org/10.1089/hyb.1989.8.369
- Lee, G. M., B. K. Han, J. H. Kim, and B. O. Palsson (1992) Effect of calcium-chloride treatment on hybridoma cell viability and growth. Biotechnol. Lett. 14: 891-896 https://doi.org/10.1007/BF01020624
- Kim, Y. N., H. G. Kim, S. K. Lim, K. Y. Park, J. S. Park, H. Murakami, and H. Y. Lee (1996) The economic production of anti-microbial factor from human promyelocytes in low serum containing medium under chemostat cultivation. Cytotechnology 19: 73-78 https://doi.org/10.1007/BF00749757
- Chaplen, F. W. R. (1998) Incidence and potential implications of the toxic metabolite methylglyoxal in cell culture: A review. Cytotechnology 26: 173-183 https://doi.org/10.1023/A:1007953628840
- Ihrig, T. J., B. D. Maulawizada, B. D. Thomas, and F. S. Jacobson (1997) Fomate production by CHO cells: Biosynthetic mechanism and potential cytotoxicity. pp. 193-197. In: M. J. T. Carrondo, B. Griffiths, and J. P. Moreira (eds.). Animal Cell Technology: From Vaccines to Genetic Medicine. Kluwer Academic Publishers, Dordrecht, Netherlands
- Glacken, M. W. (1988) Catabolic control of mammaliancell culture. Bio-Technol. 6: 1041-1050 https://doi.org/10.1038/nbt0988-1041
- Newland, M., P. F. Greenfield, and S. Reid (1990) Hybridoma growth limitations: the roles of energy metabolism and ammonia production. Cytotechnology 3: 215-229 https://doi.org/10.1007/BF00365485
- Ozturk, S. S., M. R. Riley, and B. O. Palsson (1992) Effects of ammonia and lactate on hybridoma growth, metabolism, and antibody production. Biotechnol. Bioeng. 39: 418-431 https://doi.org/10.1002/bit.260390408
- Schneider, M., I. W. Marison, and U. von Stockar (1996) The importance of ammonia in mammalian cell culture. J. Biotechnol. 46: 161-185 https://doi.org/10.1016/0168-1656(95)00196-4
- Buntemeyer, H., S. Siwiora, and J. Lehmann (1997) Inhibitors of cell growth: accumulation and Concentration. pp. 651-655. In: M. J. T. Carrondo, B. Griffiths, and J. P. Moreira (eds.). Animal Cell Technology: From Vaccines to Genetic Medicine. Kluwer Academic Publishers, Dordrecht, Netherlands
- Lee, Y. K., P. K. Yap, and A. P. Teoh (1995) Correlation between steady-state cell concentration and cell-death of hybridoma cultures in chemostat. Biotechnol. Bioeng. 45: 18-26 https://doi.org/10.1002/bit.260450104
- Mercille, S. and B. Massie (1994) Induction of apoptosis in nutrient-deprived cultures of hybridoma and myeloma cells. Biotechnol. Bioeng. 44: 1140-1154 https://doi.org/10.1002/bit.260440916
- Simpson, N. H., A. E. Milner, and M. Al-Rubeai (1997) Prevention of hybridoma cell death by Bcl-2 during suboptimal culture conditions. Biotechnol. Bioeng. 54: 1-16 https://doi.org/10.1002/(SICI)1097-0290(19970405)54:1<1::AID-BIT1>3.0.CO;2-K
- Singh, R. P., M. Al-Rubeai, C. D. Gregory, and A. N. Emery (1994) Cell death in bioreactors: A role for apoptosis. Biotechnol. Bioeng. 44: 720-726 https://doi.org/10.1002/bit.260440608
- Tey, B. T., R. P. Singh, L. Piredda, M. Piacentini, and M. Al-Rubeai (2000) Bcl-2 mediated suppression of apoptosis in myeloma NS0 cultures. J. Biotechnol. 79: 147-159 https://doi.org/10.1016/S0168-1656(00)00223-6
- Tey, B. T., R. P. Singh, L. Piredda, M. Piacentini, and M. Al-Rubeai (2000) Influence of bcl-2 on cell death during cultivation of a Chinese hamster ovary cell line expressing a chimeric antibody. Biotechnol. Bioeng. 68: 31-43 https://doi.org/10.1002/(SICI)1097-0290(20000405)68:1<31::AID-BIT4>3.0.CO;2-L
- Tey, B. T., R. P. Singh, and M. Al-Rubeai (2001) Programmed cell death-An overview of apoptosis in cell culture. Asia Pac. J. Mol. Biol. Biotechnol. 9: 1-28
- Tey, B. T. and M. Al-Rubeai (2005) Bcl-2 over-expression reduced the serum dependency and improved the nutrient metabolism in a NS0 cells culture. Biotechnol. Bioprocess Eng. 10: 254-261 https://doi.org/10.1007/BF02932022
- Leelavatcharamas, V. (1997) Growth, Gamma Interferon Production and Cell Cycle in Batch, Continuous and Perfusion Cultures. Ph.D. Thesis. The University of Birmingham, Birmingham, UK
- Singh, R. P., A. N. Emery, and M. Al-Rubeai (1996) Enhancement of survivability of mammalian cells by overexpression of the apoptosis-suppressor gene bcl-2. Biotechnol. Bioeng. 52: 166-175 https://doi.org/10.1002/(SICI)1097-0290(19961005)52:1<166::AID-BIT17>3.0.CO;2-M
- Perani, A., R. P. Singh, R. Chauhan, and M. Al-Rubeai (1998) Variable functions of Bcl-2 in mediating bioreactor stress-induced apoptosis in hybridoma cells. Cytotechnology 28: 177-188 https://doi.org/10.1023/A:1008002319400
- Tey, B. T. and M. Al-Rubeai (2004) Suppression of apoptosis in perfusion culture of Myeloma NS0 cells enhances cell growth but reduces antibody productivity. Apoptosis 9: 843-852 https://doi.org/10.1023/B:APPT.0000045792.63249.5a
- Tey, B. T. and M. Al-Rubeai (2005) Effect of Bcl-2 overexpression on cell cycle and antibody productivity in chemostat cultures of myeloma NS0 cells. J. Biosci. Bioeng. In press
- Simpson, N. H., R. P. Singh, A. Perani, C. Goldenzon, and M. Al-Rubeai (1998) In hybridoma cultures, deprivation of any single amino acid leads to apoptotic death, which is suppressed by the expression of the bcl-2 gene. Biotechnol. Bioeng. 59: 90-98 https://doi.org/10.1002/(SICI)1097-0290(19980705)59:1<90::AID-BIT12>3.0.CO;2-6