한국임상약학회지 (Korean Journal of Clinical Pharmacy)
- 제15권1호
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- Pages.46-49
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- 2005
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- 1226-6051(pISSN)
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- 2508-786X(eISSN)
인체혈청 중 펜톡시필린의 정량을 위한 HPLC 분석법의 점증 및 단일용량 투여에 의한 약물동태
Validation of a HPLC Method for Determination of Pentoxifylline in Human Serum and Its Application to Single-dose Pharmacokinetics
- 성민경 (이화여자대학교 약학대학) ;
- 박효민 (이화여자대학교 약학대학) ;
-
김나형
(이화여자대학교 약학대학) ;
-
정수연
(이화여자대학교 약학대학) ;
- 고은정 (이화여자대학교 약학대학) ;
-
이화정
(이화여자대학교 약학대학)
- Sung, Min Kyung (College of Pharmacy, Ewha Womans University) ;
- Park, Hyo Min (College of Pharmacy, Ewha Womans University) ;
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Kim, Na Hyung
(College of Pharmacy, Ewha Womans University) ;
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Chung, Soo Yeon
(College of Pharmacy, Ewha Womans University) ;
- Go, Eun Jung (College of Pharmacy, Ewha Womans University) ;
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Lee, Hwa Jeong
(College of Pharmacy, Ewha Womans University)
- 발행 : 2005.06.01
초록
A simple HPLC method was employed for the determination of pentoxifylline in human serum. After addition of internal standard (IS, 50 uL of 3 ug/mL chloramphenicol methanol solution) into the serum sample, the drug and IS were extracted by dichloromethane. Following a 1-min vortex-mixing and a 15-min centrifugation at 3500 게m, the organic phase was transferred and evaporated to dryness under a vacuum. The residue was reconstituted with 120