참고문헌
- 2002 Annual Report of the Korea Central Cancer Registry, Ministry of Health and Welfare Republic of Korea
- Toita T, Nakano M. Higashi M. Sakumoto K, Kanazawa K. Prognostic value of cervical size and pelvic lymph node status assessed by computed tomography for patients with uterine cervical cancer treated by radical radiation therapy. Int J Radiat Oncol Biol Phys 1995;843-849 https://doi.org/10.1016/0360-3016(95)00204-5
- Ohara K. Tanaka YO. Tsunoda. et al. Nonoperative assessment of nodal status for locally advanced cervical squamous cell carcinoma treated by radiotherapy with regard to patterns of treatment failure. Int J Radiat Oncol Biol Phys 2003;55:354-361 https://doi.org/10.1016/S0360-3016(02)03930-5
- Eifel PJ. Morris M, Wharton JT. Oswald MJ. The influence of tumor size and morphology on the outcome of patients with FIGO stage IB squamous cell carcinoma of the uterine cervix. Int J Radiat Oncol Biol Phys 1994;29:9-16 https://doi.org/10.1016/0360-3016(94)90220-8
- Lowe SW, Schmitt EM, Smith SW, Osborne BA, Jacks T. p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 1993;362:847-849 https://doi.org/10.1038/362847a0
- Isobe M, Emanuel BS, Givol D, Oren M, Croce CM. Location of gene for human p53 tumour antigen to band 17p13. Nature 1986;320:84-85 https://doi.org/10.1038/320084a0
- Hall PA, Meek D, Lane DP. p53-integrating the complexity. J Pathol 1996;180:1-5 https://doi.org/10.1002/(SICI)1096-9896(199609)180:1<1::AID-PATH712>3.0.CO;2-U
- EI-Deiry WS, Harper JW, O'Connor PM, et al. WAF/ CIPI in p53-mediated G1 arrest and apoptosis. Cancer Res 1994:54:1169-1174
- Yang E, Korsmeyer SJ. Molecular thanatopsis: a discourse on the BCL2 family and cell death. Blood 1996;88:386-401
- Yang J, Liu X, Bhalla K, et al. Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science 1997;275:1129-1132 https://doi.org/10.1126/science.275.5303.1129
- Miyashita T, Krajewski S, Kraiewska M, et al. Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene 1994;9:1799-1805
- Liang XH, Mungal S, Ayscue A, et al. Bcl-2 protooncogene expression in cervical carcinoma cell lines containing inactive p53. J Cell Biochem 1995:57:509-521 https://doi.org/10.1002/jcb.240570316
- Ishikawa H, Mitsuhashi N, Sakurai H, Maebayashi K, Niibe H. The effects of p53 status and human papillomavirus infection on the clinical outcome of patients with stage IIIB cervical carcinoma treated with radiation therapy alone. Cancer 2001;91:80-89 https://doi.org/10.1002/1097-0142(20010101)91:1<80::AID-CNCR11>3.0.CO;2-E
- Ebara T, Mitsuhashi N, Saito Y, et al. Prognostic significance of immunohistochemically detected p53 protein expression in stage IIIB squamous cell carcinoma of the uterine cervix treated with radiation therapy alone. Gynecol Oncol 1996;63:216-218 https://doi.org/10.1006/gyno.1996.0309
- Jaros E, Perry RH, Adam L, et al. Prognostic implications of p53 protein, epidermal growth factor receptor, and Ki-67 labelling in brain tumors. Br J Cancer 1992;66:373-385 https://doi.org/10.1038/bjc.1992.273
- Awwad S, Jaros E, Somes J, Lunec J. P53 overexpressian in head and neck carcinoma and radiotherapy results. Int J Radiat Oncol Biol Phys 1996;34:323-332 https://doi.org/10.1016/0360-3016(95)02108-6
- Allred DC, Clark GM, Elledge R, et al. Association of p53 protein expression with tumor cell proliferation rate and clinical outcome in node-negative breast cancer. J Natl Cancer Inst 1993;85:200-206 https://doi.org/10.1093/jnci/85.3.200
- Harris M, Metcalf RA, Welsh A, Montesano R, Harris CC. Frequent mutation of the p53 gene in human esophageal cancer. Proc Natl Acad Scc USA 1990;887:9958-9961
- Iwava K, Tsuda H, Hiraide H, et al. Nuclear p53 immunoreaction associated with poor prognosis of breast cancer. Jpn J Cancer Res 1991;82:835-840 https://doi.org/10.1111/j.1349-7006.1991.tb02710.x
- Tjalma W, De Cuyper E, Weyler J, et al. Expression of bcl-2 in invasive and in situ carcinoma of the uterine cervix. Am J Obstet Gynecol 1998;178:113-117 https://doi.org/10.1016/S0002-9378(98)70636-2
- Stehman FB, Bundy BN, Disasia PJ, Keys HM, Larson JE. Fowler WC. Carcinoma of the cervix treated with radiation therapy. I. A multi-variate analysis of prognostic variables in the Gynecologic Oncology Group. Cancer 1991;67:2776-2785 https://doi.org/10.1002/1097-0142(19910601)67:11<2776::AID-CNCR2820671111>3.0.CO;2-L
- Kristensen GB. Abeler VM. Risberg B. Trope C. Bryne M. Tumor size. depth of invasion and grading of the invasive tumor front are the main prognostic factors in early squamous cell cervical carcinoma. Gynecol Oncol 1999;74:245-251 https://doi.org/10.1006/gyno.1999.5420
- Kim HJ. Kim WC. Lee MJ. Kim CS. Song ES. Loh JK. Comparison of the result of radiation alone and radiation with daily low dose cisplatin in management of locally advanced cervical cancer. J Korea Soc Ther Radiol Oncol 2004;22:200-207
- Harris CC. Hollstein M. Clinical implications of the p53 tumor-suppressor gene. N Engl J Med 1993;329:1318-1327 https://doi.org/10.1056/NEJM199310283291807
- Hall PA. Lane DP. P53 in tumour pathology: can we trust immunohistochemistry?-Revisited! J Pathol 1994;172:1-4 https://doi.org/10.1002/path.1711720103
- Marchetti A. Buttitta F. Merlo G. et al. p53 alterations in non-small cell lung cancers correlated with metastatic involvement of hilar and mediastinal lymph nodes. Cancer Res 1993;53:2864-2851
- Skirnisdottir I. Seidal T. Gerdin E. Sorbe B. The prognostic importance of p53. bcl-2. and bax in early stage epithelial ovarian carcinoma treated with adjuvant chemotherapy. Int J Gynecol Cancer 2002;12:265-276 https://doi.org/10.1046/j.1525-1438.2002.01121.x
- l.ipponan P. Ji H. Aaltomaa S. Syrianen S. Syrianen K. p53 protein expression in breast cancer as related to histopathological characteristics and prognosis. Int J Cancer 1993;55:51-56 https://doi.org/10.1002/ijc.2910550110
- Couture G. Raybaud-Diogene H. Tetu B. et al. p53 and Ki-67 as markers of radioresistance in head and neck carcinoma. Cancer 2002;94:713-722 https://doi.org/10.1002/cncr.10232
- Oka K. Nakano T. Arai T. p53CM1 expression is not associated with prognosis in uterine cervical carcinoma. Cancer 1993;72:160-164 https://doi.org/10.1002/1097-0142(19930701)72:1<160::AID-CNCR2820720130>3.0.CO;2-C
- Gitsch G. Kainz C. Joura E. Breitenecker G. Mutant p53 product in patients with stage III cervical cancer. Anticancer Res 1992;12:2241-2242
- Kainz C. Kohlberger P. Gitsch G. Sliutz G. Breitenecker G. Reinthaller A. Mutant p53 in patients with invasive cervical cancer stage IB to IIB. Gynecol Oncol 1995;57:212-214 https://doi.org/10.1006/gyno.1995.1127
- Holm R. Skomedal H. Helland P. Kristensen G. Borresen AL. Nesland JM. Immunohistochemical analysis of p53 protein overexpression in normal. premalignant. and malignant tissue of the cervix uteri. J Pathol 1993;169:21-26 https://doi.org/10.1002/path.1711690105
- Raikumar T. Haian S. Baruah RK. Majhi U. Selvaluxmi G. Vasanthan A. Prognostic significance of Bcl-2 and p53 protein expression in stage IIB and IIIB squamous cell carcinoma of the cervix. Eur J Gynaecol Oncol 1998;19:556-560
- Pillai MR. Jayacrakash PG. Nair MK. Bcl-2 immunoreactivity but not p53 accumulation associated with tumour response to radiotherapy in cervical carcinoma. J Cancer Res Clin Oncol 1999;125:55-60 https://doi.org/10.1007/s004320050242
- Jain D. Srinivasan R. Patel FD. Kumari Gupta S. Evaluation of p53 and Bcl-2 expression as prognostic markers in invasive cervical carcinoma stage IIb/III patients treated by radiotherapy. Gynecol Oncol 2003;88:22-28 https://doi.org/10.1006/gyno.2002.6838
- Dimitrakakis C. Kymionis G. Diakomanolis E. et al. The possible role of p53 and bcl-2 expression in cervical carcinomas and their premalignant lesions. Gynecol Oncol 2000;77:129-136 https://doi.org/10.1006/gyno.1999.5715
- Werness BA. Levine AJ. Howley PM. Association of human papillomavirus type 16 and 18 E6 proteins with p53. Science 1990;248:76-79 https://doi.org/10.1126/science.2157286
- Park TW. Fujiwara H. Wright TC. Molecular biology of cervical cancer and its precursors. Cancer 1995:76:1902-1913 https://doi.org/10.1002/1097-0142(19951115)76:10+<1902::AID-CNCR2820761306>3.0.CO;2-0
- Chittenden T. Harrington EA. O'Connor R. et al. Induction of apoptosis of the Bcl-2 homologue Bak. Nature 1995;374:733-736 https://doi.org/10.1038/374733a0
- Wootipoom V. Lekhyananda N. Phungrassami T. Boonyaphiphat P. Thongsuksai P. Prognostic significance of Bax, Bcl-2, and p53 expressions in cervical squamous cell carcinoma treated by radiotherapy. Gynecol Oncol 2004;94:636-642 https://doi.org/10.1016/j.ygyno.2004.03.012
- Crawford RA, Caldwell C. Iles RK. Lowe D. Shepherd JH. Chard T. Prognostic significance of the bcl-2 apoptotic family of proteins in primary and recurrent cervical cancer. Br J Cancer 1998;78:210-214 https://doi.org/10.1038/bjc.1998.466
- Tjalma WA, Weyler JJ. Bogers JJ, et al. The importance of biological factors (bcl-2, bax, p53, PCNA, MI, HPV and angiogenesis) in invasive cervical cancer. Eur J Obstet Gynecol Reprod Biol 2001;97:223-230 https://doi.org/10.1016/S0301-2115(00)00541-8
- Harima Y. Harima K, Shikata N. Oka A. Ohnishi T, Tanaka Y. Bax and bcl-2 expressions predict response to radiotherapy in human cervical cancer. J Cancer Res Clin Oncol 1998;124:503-510 https://doi.org/10.1007/s004320050206
- Mukherjee G, Freeman A. Moore R, et al. Biologic factors and response to radiotherapy in carcinoma of the cervix. Int J Gynecol Cancer 2001:11:187-193 https://doi.org/10.1046/j.1525-1438.2001.01014.x
- Chung TK. Cheung TH, Lo WK, et al. Expression of apoptotic regulators and their significance in cervical cancer. Cancer Lett 2002;180:63-68 https://doi.org/10.1016/S0304-3835(01)00842-4
- Korsmever SJ. Bcl-2 initiates a new category of oncogenes: regulators of cell death. Blood 1992;80:879-886
- Lipponen PK, Aaltomaa S, Eskelinen M. Expression of the apoptosis suppressing bcl-2 protein in transitional cell bladder tumors. Histopathology 1996;28:135-140 https://doi.org/10.1046/j.1365-2559.1996.276322.x
- Bubendorf L, Sauter G, Moch H, et al. Prognostic significance of Bcl-2 in clinically localized prostate cancer. Am J Pathol 1996;148:1557-1565
- Lipponen P, Pietilainen T, Kosma VM, Aaltomaa S, Eskelinen M, Syrianen K. Apoptosis suppressing protein bcl-2 is expressed in well-differentiated breast carcinomas with a favourable prognosis. J Pathol 1995;177:49-55 https://doi.org/10.1002/path.1711770109
- Diebold J, Baretton G, Felchner M, et al. bcl-2 expression, p53 accumulation, and apoptosis in ovarian carcinomas. Am J Clin Pathol 1996;105:341-349 https://doi.org/10.1093/ajcp/105.3.341
- Spafford M F, Koeppe J, Pan Z, Archer PG, Mevers AD, Franklin WA. Correlation of tumor markers p53, bcl-2, CD34, CD44H, CD44v6, and Ki-67 with survival and metastasis in laryngeal squamous cell carcinoma. Arch Otolaryngol Head Neck Surg 1996;122:627-632 https://doi.org/10.1001/archotol.1996.01890180035010
- Halder S, Negrini M, Monne M, Sabbioni S, Croce CM. Down-regulation of bcl-2 by p53 in breast cancer cells. Cancer Res 1994;54:2095-2097
- Chiou SK, Rao I, White E. Bcl-2 blocks p53-dependent apoptosis. Mol Cell Biol 1994;14:2556-2563 https://doi.org/10.1128/MCB.14.4.2556
- Oltvai ZN, Milliman CL, Korsmever SJ. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 1993;74:609-619 https://doi.org/10.1016/0092-8674(93)90509-O
- Henriksen R, Wilander E, Oberg K. Expression and prognostic significance of Bcl-2 in ovarian tumors. Br J Cancer 1995;72:1324-1329 https://doi.org/10.1038/bjc.1995.509
- Jain D, Srinivasan R, Patel FD, Kumari Gupta S. Evaluation of p53 and Bcl-2 expression as prognostic marker in invasive cervical carcinoma stage IIb/III patients treated by radiotherapy. Gynecol Oncol 2002;88:22-28 https://doi.org/10.1006/gyno.2002.6838