Drug Interaction Review of Prescriptions for Outpatients at General Hospital

종합병원의 외래환자 처방전에 대한 약물상호작용 검토

  • Cho, Jin Hoan (Department of Hospital and Clinical Pharmacy, The Graduate School of Food and Drug Administration, Chung Ang Univercity) ;
  • Choi, Byung Chul (Department of Hospital and Clinical Pharmacy, The Graduate School of Food and Drug Administration, Chung Ang Univercity) ;
  • Sohn, Uy Dong (Department of Hospital and Clinical Pharmacy, The Graduate School of Food and Drug Administration, Chung Ang Univercity)
  • 조진환 (중앙대학교 의약식품대학원 병원임상약학) ;
  • 최병철 (중앙대학교 의약식품대학원 병원임상약학) ;
  • 손의동 (중앙대학교 의약식품대학원 병원임상약학)
  • Published : 2005.10.01

Abstract

To investigate drug interaction, 23,536 prescriptions published for 1 year were investigated with 'Drug Inter­action Fact 2002'. Dispensing records and a database file written in a local general hospital in South Korea were used as a sample. The number of total cases of drug interaction was 3,238 ($13.76\%$) out of 23,536 prescriptions. The incidence of drug interaction in each prescription the children, the adults, and the elderly were $1.33\%,\;10.97\%,\;25.50\%$, respectively. The incidences of drug interaction per each prescription were $22.03\%,\;20.52\%,\;0.51\%,\;and\;0.36\%$ in neurosurgery, internal med­icine, pediatrics, and orthopedics, respectively. In neurosurgery and internal medicine, risk-high drugs of drug interaction such as antihypertensive drugs, diuretics, and cimetidine were used very often in elderly. In this paper, several suggestions to reduce drug interaction were postulated with regard to the usage of analgesics, non-steroidal antiinflammatory drugs, and antibiotics.

Keywords

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