대한의생명과학회지 (Biomedical Science Letters)
- 제11권3호
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- Pages.365-373
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- 2005
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- 1738-3226(pISSN)
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- 2288-7415(eISSN)
Alterations in Meningeal Blood Flow by Stimulation of Trigeminovascular System in Rats
- Kim, Byung-Soo (Department of Neurosurgery, College of Medicine, Pusan National University) ;
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Choi, Chang-Hwa
(Department of Neurosurgery, College of Medicine, Pusan National University) ;
- Lee, Won-Suk (Department of Pharmacology, College of Medicine, Pusan National University)
- 발행 : 2005.09.01
초록
The aim of this study was to investigate the alterations in meningeal blood flow by stimulation of trigeminovascular system. An open cranial window was prepared on the right parietal bone of male Sprague-Dawley rats. Trigeminovascular system was stimulated by electrical stimulation of trigeminal ganglion (ETS), somatosensory (whisker) stimulation, or topical applications of capsaicin and neuropeptides including substance P and calcitonin gene-related peptide (CGRP). Neonatal capsaicin pretreatment was performed with subcutaneous administration of capsaicin (50 mg/kg) within the first 24 hours after birth. Changes in regional blood flow of dural artery (rDBF) and pial artery (rPBF) were continuously measured through the cranial window by laser-Doppler flowmetry. Both ETS and capsaicin caused a chain of alterations in rPBF and rDBF responses, i.e., an immediate transient decrease followed by rapid and marked increase in rPBF, which were significantly attenuated not only by pretreatments with L-733,060, a