Korean Journal of Community Nutrition (대한지역사회영양학회지)

The Korean Society of Community Nutrition (대한지역사회영양학회)
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A Change of Serum Folate and Vitamin $B_{12}$ Concentrations of Maternal and Umbilical Cord Blood during Pregnancy

임신 중 모체와 신생아 제대 혈청의 엽산과 비타민 $B_{12}$ 농도 변화

  • Lee, Geum-Ju (Department of Food & Nutrition, Sungshin Women's University) ;
  • Jang, Hey-Mi (Department of Food & Nutrition, Sungshin Women's University) ;
  • Ahn, Hong-Seok (Department of Food & Nutrition, Sungshin Women's University)
  • 이금주 (성신여자대학교 식품영양학과) ;
  • 장혜미 (성신여자대학교 식품영양학과) ;
  • 안홍석 (성신여자대학교 식품영양학과)
  • Published : 2005.10.01
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Abstract

Folate and Vitamin $B_{12}$ are essential nutrients important during pregnancy. This study was conducted to evaluate the folate and vitamin $B_{12}$ nutritional status of Korean pregnant women and to investigate the relationship between maternal­umbilical cord serum folate and vitamin B12 levels and pregnancy outcomes. Dietary intakes of the pregnant women were estimated by 24 hour-recall (3 times). Serum folate and vitamin B12 levels in maternal blood and umbilical cord of 27 pregnant women at 1'st-, 2'nd-, 3'rd-trimester and delivery were measured by RIA (radioimmuno assay), respectively. Means of folate and vitamin $B_{12}$ intake were $283.53\pm58.01{\mu}g/day\;and\; 2.99\pm1.32mg/day$, respectively. Maternal mean serum folate levels of the trimester and delivery were $9.75\pm3.60ng/ml,\;10.46\pm4.63ng/ml,\;10.71\pm4.14ng/ml\;and\;15.05\pm7.04ng/ml$. Those maternal levels were significantly lower than that of umbilical cord blood $(23.99\pm9.42ng/ml)$. Serum vitamin $B_{12}$ levels of maternal trimester and delivery were $479.07\pm137.56 pg/ml,\;310.96\pm137.56pg/ml,\;308.22\pm74.65pg/ml,\;and\;295.67\pm93.36pg/ml$, which were significantly lower than those of umbilical cord blood $(500.13\pm185.60ng/ml)$. This finding indicates that the uptake of folate and vitamin $B_{12}$ in the fetus may be due to an active placental transport mechanism. Maternal serum level correlated positively with those of umbilical cord blood, showing that folate and vitamin $B_{12}$ concentration of umbilical cord blood might be affected by maternal status. There was no significant correlation between the serum folate levels in maternal-umbilical cord blood and the pregnancy outcomes. However, maternal vitamin $B_{12}$ level at l'st trimester was significant positive correlation between the gestational age except for birth weight and weight gain.

Keywords

References

  1. Alan HP, Alan A (I990): Clinicla assement of nutritional status - A working manual. 2nd ed. p.67, Williams & Wilkins Publishing, USA
  2. Ahn HS (2004): Maternal plasma homocysteine levels and pregnancy outcomes. Korean J Community Nutrition 9 (4): 483-490
  3. Ahn HS, Kim JS, Lee GJ, Kim YT (2000): Serum Folate Levels of Maternal-Umbilical Cord Blood and Pregnancy Outcomes. Korean J Nutrition 33 (8): 840-847
  4. Ahn HS, Lee GJ, Hong HK, Chung SW, Yang JH, Chung HW (2001): Serum Vitamin $B_{12}$ Levels of Maternal-Umbilical Cord Blood and Pregnancy Outcomes. Korean J Nutrition 34(4): 426-432
  5. Baker H, Frank O, Deangelis B, Feingold S, Kaminetky HA (1981)): Role of placenta in maternal-folate vitamin transfer in human. Am J Obstet Gynecol 141: 792-796
  6. Candito M, Houcher B, Boisson C, Abellard J, Demarcq MJ, Gueant JL, Benhacine K, Gerard P, Van Obberghen E (2004): Neural tube defects and vitamin $B_{12}$: a report of three cases. Ann Biol Clin 62(2): 235-238
  7. Cikot RJ, Steegers-Theunissen RP, Thomas CM, de Boo TM, Merkus HM, Steegers EA (2001): Longitudinal vitamin and homocysteine levels in normal pregnancy. Br J Nutr 85 (1): 49-58 https://doi.org/10.1079/BJN2000209
  8. Dansky LV (1987): Anticonvulsants, folate levels and pregnancy outcome: a prospective study. Ann Neurol 21: 176 https://doi.org/10.1002/ana.410210210
  9. Dietrich M, Brown CJ, Block G (2005): The effect of folate fortification of cereal-grain products on blood folate status, dietary folate intake, and dietary folate sources among adult non-supplement users in the United States. J Am Coll Nutr 24 (4): 266-274
  10. Dawson DW, Fish DI, Frew IDO, Roome T, Tilson I (1987): Laboratory diagnosis of megaloblastic anemia: current methods assessed by external quality assurance trials. J Clin Pthol 40: 393-397 https://doi.org/10.1136/jcp.40.4.393
  11. Ek J, Magnus EM (1981): Plasma and red blood cell folate during normal pregnancies. Acta Obstet Gynecol Scand 60(3): 241-251
  12. Frety N, Heul G, Leory M, Morean T, Savard R, Blot P, Lellouch J (1992): Vitamin $B_{12}$ among parturients and their newborns and its relationship with birthweight, Eur J Obstet Gynecol Repord Biol 45: 155-163 https://doi.org/10.1016/0028-2243(92)90076-B
  13. Gilbert W, Jandial D, Field N, Bigelow P, Danielsen B (2004): Birth outcomes in teenage pregnancies. J Matern Fetal Neonatal Med 16(5): 265-270 https://doi.org/10.1080/14767050400018064
  14. Guerra-Shinohara EM, Paiva AA, Rondo PH, Yamasski K, Terzi CA, D'Almeida V (2002): Relationship between total homocysteine and folate levels in pregnancy women and their newborn babies according to maternal serum levels of vitamin $B_{12}$. BJOG 109 (7): 784-791 https://doi.org/10.1111/j.1471-0528.2002.01307.x
  15. Herbert V, Ziegler E, Filer LJ (1998): Vitamin $B_{12}$, In: Present knowledge in nutrition (7th) ed. The orean nutrition society and international life sciences institute of Korea, p.194
  16. Huber AM, Willins LL, Derusso P (1988): Folate nutriture in pregnancy. J Am Diet Assoc 88: 791-795
  17. Hurley LS (1980): Water-soluble vitamins. In: Developmental nutrition. pp.163-164, Prentice Hall
  18. Hyen WJ, Lee JY, Kwak CS (1997): Dietary intakes and psychological stress of pregnant women in Taejon in relation to neonatal birth weight. Korean J Community Nutrition 2 (2): 169-178
  19. Institute of Medicine (1990): Committe on nutritional status during pregnancy and lactation. Nutrition during pregnancy, National Academy Press, Washington DC
  20. Kang M, Chang N (1993): Effect of dietary folate intakes of serum folate levels of pregnant and lactating women. Korean J Nutrition 26(4): 433-442
  21. Kretchmer N, Zimmermann M (1997): Nutritional needs of the mother and fetal in pregnancy. In: Developmental nutrition. Allyn and Bacon, pp.96-97
  22. Kubler W (1981): Nutritional deficiencies in pregnancy. Bibl Nutr Dieta 30: 17-29
  23. Lee EJ, Kim MH, Cho MS, Kim YJ, Kim WY (2003): A study on nutrition intakes and hematological status in women of child-bearing age: comparison between non-pregnant and pregnant women. Korean J Nutr 36(2): 191-199
  24. Lim HS, Lee JA (1998): Folate levels of umbilical cord blood and pregnancy outcomes. Korean J Nutr 31 (8): 1263-1269
  25. Lee JA, Lee Jl, Lim HS (2004): Maternal folate status and its influencing factors in early pregnancy. J Korean Soc Food Sci Nutr 33 (2): 331-338 https://doi.org/10.3746/jkfn.2004.33.2.331
  26. Lindenbaum J, Healton EB, Savage DG (1988): Neuropsychiatric disorder caused by cobalamin deficiency in the absence of anemia or macrocytosis. N Engl J Med 318: 1720-1728 https://doi.org/10.1056/NEJM198806303182604
  27. Molly AM (1985): Martenal serum folate and vitamn $B_{12}$ concentration in pregnancies associated with neural tube defects. Arch Dis Child 60:660 https://doi.org/10.1136/adc.60.7.660
  28. Mudd SH, Levy HL, Skowby F (1995): Disorders of transsulfuration. In: Scriver CR, Beaudet AL, Sly WS, Valle D, des. The metabolic and molecular bases of inherited disease. New York: McGrawhill 1279-1327
  29. Nalinow MR, Rajkovic A, Duell PB, Hess DL, Upson BM (1998): The relationship between maternal and neonatal umbilical cord plasma homocysteine suggests a potential role for maternal homocysteine in fetal metabolism. Am J Obstet Gymecol 178: 228-233 https://doi.org/10.1016/S0002-9378(98)80005-7
  30. Pardo J, Gindes L, Orvieto R (2004): Cobalamin (vitamin $B_{12}$) metabolism during pregnancy. Int J Gynecol Obstat 84 (1): 77-78 https://doi.org/10.1016/S0020-7292(03)00257-1
  31. Picciano MF (1996): Pregnancy and Lactation. Present knowledge in nutrition 7th ed In: 37. International Life Sciences Institute -Nutrition FoundationILSI Press, Washington, D.C., pp.390-401
  32. Rosenblatt DS (1995): Inherited disorders of folate transport and metabolism. In: Scriver CR, Beaudet AL, Sly WS, Valle D, des. The metabolic and molecular bases of inherited disease. New York: McGrawhill, pp.3111-3128
  33. Sauberlich HE (1999): Laboratory tests for the assessment of nutritional status, 2nd ed. CRC Press, Washington, D.C
  34. Scholl TO, Hediger ML, Schall JI, Khoo CS, Fischer RL (1996): Dietary and serum folate: their influence on the outcome of pregnancy. Am J Clin Nutr 63: 520-525
  35. Scholl TO, Johnson WG (2000): Folic acid: influence on the outcome of pregnancy. Am J Clin Nurt 71 (s): 1295s-1303s
  36. Shojania AM (1984): Folic acid and vitamin $B_{12}$ deficiency in pregnancy and in the neonatal period. Clinics in Perinatology 11: 433-459
  37. The Korean Nutrition Society (2000): Recommended Dietary Allowance for Koreans, 7th ed. Jungang Press, Seoul
  38. Theresa OS, William GJ (2000): Folic acid: influence on the outcome of pregnancy. Am J Clin Nutr 71 (S): 1295S-1303S
  39. Van den Berg H (1998): Vitamin and mineral states in healthy pregnant women. Symposium Nestle-Hoffmann-La Roche. Workshop series 16: 93-108, Raven Press. New York
  40. Weiss R, Fogelman Y, Bennett M (2004): Severe vitamin $B_{12}$ deficiency in an infant associated with a maternal deficiency and a strict vegetarian diet. J Pediatr Hematol OncoI 24(4): 270-271
  41. Yates AA, Schlicker SA, Suitor CW (1998): Dietary referance intakes: The new basis for recommendation for calcium and related nutrients, vitamins and choline. J Am Diet Assoc 98: 699-706 https://doi.org/10.1016/S0002-8223(98)00160-6