생명과학회지 (Journal of Life Science)

  • 제15권5호
  • /
  • Pages.834-839
  • /
  • 2005
  • /
  • 1225-9918(pISSN)
  • /
  • 2287-3406(eISSN)
한국생명과학회 (Korean Society of Life Science)
권호 표지
DOI QR코드

DOI QR Code

난소를 절제한 흰쥐에서 오디가 혈 중 지질 함량 변화에 미치는 영향

Effects of Mulberry fruits Extracts on Serum Lipid Level in Ovariectomized Rats

  • 최경하 (신라대학교 자연과학대학 식품영양학과) ;
  • 박미화 (신라대학교 자연과학대학 식품영양학과) ;
  • 김미향 (신라대학교 자연과학대학 식품영양학과)
  • Choi Kyung-Ha (Department of Food science and Nutrition, Silla University) ;
  • Park Mi-Hwa (Department of Food science and Nutrition, Silla University) ;
  • Kim Mihyang (Department of Food science and Nutrition, Silla University)
  • 발행 : 2005.10.01
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

여성은 폐경 시 음식물 섭취가 증가하여 체중이 증가되고, 정상 여성보다 혈류관련질환 발병이 높아진다. 이에 본 연구에서는 갱년기 장애시 유발되는 체내 지질 함량 증가에 있어 오디 추출물이 미치는 영향을 조사하기 위해 인위적 폐경을 유발시킨 난소절제 횐쥐에 오디추출물을 투여하여 그에 따른 혈 중 효소 활성 및 지질 함량에 미치는 영향을 검토하였다. 그 결과 난소 절제 후 오디추출물 투여는 난소절제로 인해 야기되는 혈 중 total- cholesterol 함량 및 혈청 지질농도의 증가를 감소하였다. 하지만 HDL-cholesterol은 난소절제 군에 비해 난소절제 후 오디추출물을 투여할 경우 그 수치가 증가하였으며, LDL-cholesterol은 반대로 감소하는 것을 볼 수 있어 오디추출물이 갱년기 장애 시 발생할 수 있는 혈 중 지질함량 변화에 효과가 있는 것으로 나타나 혈류관련질환에 대한 개선 식품으로의 활용이 기대된다.

The aim of this study was to evaluate the effects of three different mulberry cultivars extracts on serum lipid contents in ovariectomized estrogen-deficient rats. Sprague-Dawley female rats were randomly assigned to the following groups: sham-operated rats (sham), ovariectomized control rats (OVX-control), ovariectomized rats supplemented with $ 80\% $ ethyl alcohol extracts from various kinds of Tajikistan mulberry (OVX-TM), Korea mulberry (OVX-KM) and China mulberry (OVX-CM) at 200mg/kg bw/day, respectively. The mulberry extracts were orally administrated at 1mL per day. The body weights of OVX rats were significantly heavier than the sham-operated rats at all values (p <0.05). The ovariectomy caused an expected increasing in the levels of serum total cholesterol and triglyceride. The serum HDL-cholesterol level on the OVX-TM, OVX-KM and OVX-CM groups were higher than in the OVX-control group.

키워드

참고문헌

  1. Asano, Tomioka, E. Kizu, H. and K. Matsui. 1994. Sugars with nitrogen in the ring isolated from the Morus bombysis. Carbohydr. Res 253, 235-245 https://doi.org/10.1016/0008-6215(94)80068-5
  2. Basnet, P., Kodota, S., Terashima, S., Shimizu, M. and Namba, T. 1993. Two new 2-arylbenzofuran derivatives from hypoglycemic activity-bearing fractions of Morus insignis. Chem. Pharm. Bull 41, 1238-1243 https://doi.org/10.1248/cpb.41.1238
  3. Bush T. L., V. T. Miller. Menopause. Physiology and Pharmacology. Chicago, IL. Year Book, 187-208
  4. Chen, F, Nakashima, N. Kimura, I. and Kimura, M. 1995. Hypoglycemic activity and mechanisms of extracts from mulberry leaves (Folium mori) and cortex mori radicis in streptozotocin-induced diabetic mice. Akugaku Zasshi 15, 476-482
  5. Cha, J. Y, H. J. Kim, Y. S. Cho. 2000. Effects of water-soluble extract from leaves of Morus alba and Cudrania tricuspidata on the lipid peroxidation in Tissues of rats. J. Korean soc. Food sci. Nutr 29, 531-536
  6. Cha, J. Y, H. J. Jun, B. S. and Y. S. Cho. 2000. Effect of watersoluble extract from leaves of Morus alba and Cudrania tricuspidata on the lipid concentrations of serum and liver in rats. J. Korean soc. Agric. Chem. Biotechnol 43, 303-308
  7. Cho, S. Y, and J. Y. Park. 2000. Effect of dandelion leaf extracts on lipid metabolism in rats fed high cholesterol diet. J. Korean Sci. Nutr. 29, 676-682
  8. Cho, S. H, S. W. Choi. 2001. Effects of defatted safflower and perilla seed powders on lipid metabolism in ovariectomized female rats fed high cholesterol diets. J. Korean Soc. Food Sci. Nutr 30, 112-118
  9. Goodhart, R. H and M. E. Shils,. 1980. Modern nutrition in health and disease. 6th ed. Lea and Febriger Philadelphia. 1045-1048
  10. Geary N., Asarian L,. 2001. Am J Physiol Regul Integr Compo Physiol. 1290-1294
  11. Garcia Rodriguez J. A., G. M. Pfaff., M. C. Schumacher., A. M. Walker., H. Hoffmeister. 1990. Epidemiology 1, 219-223 https://doi.org/10.1097/00001648-199005000-00007
  12. Jeong, S. H, H. H. Lee, M. Y. Han, C. Y. Ryu, M. C. Yoon. 2002. Effects of fenofibrate on body weight and lipid metabolism in female mice. Journal of the Institute of Natural Science, Mokwon University 11(1), 27-32
  13. Jeong, C. H, O. S. Joo, K. H. Shim. 2002. Chemical components and physiological activities of young mulberry (Morus alba) stem. Korean journal of Food Preservation 9(2), 228-233
  14. Jiang Du, Z. D. He, P. W. Jiang, W. C. Ye, H. X. Xu, P. H. Paul. 2003. Antiviral flavonoids from the root bark of Morus alba L. Phytochemistry 62, 1235-1238 https://doi.org/10.1016/S0031-9422(02)00753-7
  15. Jong, C. P, J. S. Choi, J. W. Choi. 1995. Effects of the fractions from the leaves, fruits, stems and roots of Cudrania tricuspidata and Flavonoids on Lipid Peroxidation. Kor. J. Pharmacogn 26(4), 377-384
  16. Kim, H. B. Bioactive componets and their functional properties of mulberry fruits as food resources. 2003. Seoul National University Library
  17. Kim, H. B, H. S. Bang, H. W. Lee, Y. S. Seuk, B. S. Gyoo. 1999. Chemical characteristics of Mulberry Syncarp. Korean J. Seric. Sci. 41(3), 123-128
  18. Kim, H. J, J. Y. Cha, M. J. Choi, Y. S. Cho. 2000, Antioxidative activities by water-soluble extracts ofmorus alba -and cudrania tricuspidata. J. Korean Soc. Agric. Chem. Biotechnol 43, 148-152
  19. Kim, H. Y. H. Y. You. 1974. Alkaling phosphatase and protein synthesis of cholestatic liver in rats. Kyung Buk Medical 6(1), 148-153
  20. Kim, M. H, W. H. Kim, M. R. Park, H. S. Han, S. J. Bae. 2003. The Effects of platycodon grandiflorum A. extracts on serum lipids content in ovariectomized rats. J. of Nat. Sci. of Silla Univ 11. 21-32
  21. Kim, S. H, H. S. Kim, J. S. Seo, H. S. Cheong, S. Y. Chung. 1992. Effects of the feeds mixed with various level of lard, perilla oil and evening primrose oil on lipid components of liver, brain and testes in rats. J. of Gyeongsang Nat. Univ. 31(2), 83-91
  22. Kim, S. Y, W. C. Lee, H. B. Kim, A. J. Kim, S. K. Kim. 1998. Antihyperlipidemci effects of methanol extracts from Mulberry leaves in cholesterol-induced hyperlipidemia rats. J. Kor. Soc. Food Sci. Nurt 27, 1217-1222
  23. Kim, S. Y, K. J. Park, W. C. Lee. 1998. Antiinflammatory and antioxidative effects of morus spp. fruit extract. Korean J. Medicinal Crop Sci 6(3), 204-209
  24. Kim, T. W, Y. B. Kwon, Lee, J. H. Yang, J. S. Youm, J. K. Lee, H. Sand J. Y. Moon. 1996. A study on the antidiabetic effect of mulberry fruits. Korean. J. Seric. Sci 38(2), 100-107
  25. Lee, J. S, M. H. Choi, S. H. Jung. 1995. Blood glucose-lowering effects of Mori Folium. yakhak Hoeji 39, 367-372
  26. Lipid Research Clinics Program. 1984. The research clinic primary prevention trial results. ll. the relationship of reduction of indence of coronary heart disease to cholesterol lowering. JAMA. 251, 365-374 https://doi.org/10.1001/jama.251.3.365
  27. Lee, Y. J, and Y. K. Kim. 2003. High science of nutrition. Sinkong Press Inc. 76-78
  28. Mattson, F. H. and S. M. Grundy (1985). Comparison of effects of dietary saturated, monounsaturated and to polyunsaturated fatty acids on plasma lipids and lipooroteins in man, J. Lipid Res., 26, 194-202
  29. Manson, J. E., H. Tosteso., P. M. Ridker, et al. 1992. 1406-141
  30. Noriaki Kume, H. Kazutaka, J. H. Atsuko, M. Manabu, M. Eri, T. Masako, A. Hidenori, K. kaeko, M. Toshinori, H. 5aburo, Y. Masayuki, K. Toru. 2004. Mulberry leaf extracts inhibit TNF-alpha-induced expression of lectin-like oxidized LDL receptor-l (LOX-I) in vascular endothelial cells. Cardiovascular pathology 13, 5105
  31. National Institutes of Health consensus development conference. 1985. Statement Lowering blood cholesterol to prevent heart disease. JAMA 253, 2080-2086 https://doi.org/10.1001/jama.253.14.2080
  32. Ortho Clinicla Diagnostics. 2001. The reference intervals in iochemical analyse of laboratory animal. Johnson-Johnson Co, New York 13-17
  33. Stampfer, M. J., G. A. Colditz., W. C. Willerr, et al. 1991. 756-762
  34. The Association of korean Clinical Pathology. 1994. The clinical pathology. Korea Medicine Co, Seoul 40-79
  35. Vega, G. L., E. Groszek, R. Wolf and S. M. Grundy (1982). Influence of PUFA on composition of plasma lipoproteins and apoIipoproteins. J. Lipid Res., 23, 811-822
  36. Wade G. N. 1975. J Comp Physiol Psychol. 183-193
  37. Wing R. R., K. A. Matthews. 1991. Arch Int Med 151, 91-102
  38. Y. H Kim, K. S Ahn, D. K Song, M. B Wie (1989). Effects of panax ginseng and radix stragali on age-related physiological alterations in rats. International symposium on east -west medicine
  39. 이완주(2003) 성인병을 예방하는 뽕잎 건강법. 중앙생활사. pp.136-137
  40. Lee C. B. 1982. Illustrated flora of Korea. 285