EFFECT OF GELATIN SPONGY AND PLATELET RICH PLASMA ON RIDGE PRESERVATION AND BONE FORMATION AFTER EXTRACTION

발치 후 젤라틴 스폰지와 혈소판 농축 혈장이 치조제 보존 및 골 형성에 미치는 영향

  • Kim, Young-Seok (Department of Oral & Maxillofacial Surgery, School of Dentistry, Wonkwang University) ;
  • Kwon, Kyung-Hwan (Department of Oral & Maxillofacial Surgery, School of Dentistry, Wonkwang University) ;
  • Cha, Soo-Yean (Department of Oral & Maxillofacial Surgery, School of Dentistry, Wonkwang University) ;
  • Min, Seung-Ki (Department of Oral & Maxillofacial Surgery, School of Dentistry, Wonkwang University)
  • 김영석 (원광대학교 치과대학 구강악안면외과학교실) ;
  • 권경환 (원광대학교 치과대학 구강악안면외과학교실) ;
  • 차수련 (원광대학교 치과대학 구강악안면외과학교실) ;
  • 민승기 (원광대학교 치과대학 구강악안면외과학교실)
  • Published : 2005.05.31

Abstract

The placement of different graft materials and/or the use of occlusive membranes to cover the extraction socket entrance are techniques aimed at reducing alveolar ridge resorption and enhancing bone formation. However, in spite of its clinical advantage, the use of graft materials in fresh extraction socket has been questioned because particles of the grafted material have been found in alveolar sockets with fibrous union. The purposes of this study were to evaluate whether alveolar ridge resorption following tooth extraction could be reduced and bone formation could be enhanced by the application of absorbable gelatin spongy or gelatin spongy soaked with platelet rich plasma(PRP) used as a space filler in clinical and radiographic aspects. Eighty patients who were scheduled for extraction of both third molars were participated and carried out by one experienced surgeon. Following extraction of teeth, one extracted socket were treated with gelatin spongy as an experimental group A and the other were treated with gelatin spongy and PRP as an experimental group B. The routine extracted socket were healed without any treatment as a control group. From the period of extraction to 12 weeks postoperatively, we examined the clinical course and radiographic evaluation on socket at regular interval. Both experimental groups showed faster wound healing process than control clinically. Vertical gingival height of the extraction socket were less changed statistically in both experimental groups than control. The horizontal width change of the extraction socket were not significant statistically in any group. Radiographic changes of the alveolar bone height were less changed in both experimental groups and bone density were showed higher than control. There were a little difference between experimental group A and B. In conclusion, absorbable gelatin sponge and with PRP were considered as having preservation effects of extraction socket and stimulation of bone formation process after extraction.

Keywords

References

  1. Cardaropoli G, Auraujo M, Lindhe J : Dynamics of bone tissue formation in tooth extraction sites; an experimental study. J Clin Periodontol 30 : 809, 2003 https://doi.org/10.1034/j.1600-051X.2003.00366.x
  2. Almer MH, Johnson PL, Salman I : Histological and histochemical investigation of Human alveolar socket healing in undistubed extraction wound. J America Dent Asso 61 : 46, 1960
  3. Evian CI, Rosenberg ES, Coslet JG, Corn H : The osteogenic activity of bone removed from healing extraction socket in humans. J Periodontol 73 : 94, 1981 https://doi.org/10.1902/jop.2002.73.1.94
  4. Atwood ; Reduction of alveolar ridges; A major disease entity. J Prosth Dent 26 : 266, 1971 https://doi.org/10.1016/0022-3913(71)90069-2
  5. Mercier P and Lafontant R : Residual ridge atrophy; Classification and influence on facial morphology. J Prosth Dent 41 : 91, 1971
  6. Lekovic V, Kenney EB, Weinlaender M : A bone regenerative approach to alveolar ridge maintenance of following tooth extraction. Report of 10 cases. J periodontol 68 : 563, 1997 https://doi.org/10.1902/jop.1997.68.6.563
  7. Seibert JS : Treatment of moderate localized alveolar ridge defects. Preventive and reconstructive concepts in therapy. Dent Clin North Am 37 : 265, 1993
  8. Gerry MR, Rutger HK, Batenburg, AV, Harry R : Augmentation of localized defects of the anterior maxillary ridge with autogenous bone before insertion of implants. J Oral Maxillofac Surg 54(10) : 1180, 1996 https://doi.org/10.1016/S0278-2391(96)90346-8
  9. Bird JS, Lullbom TL, Quast GL : Alveolar ridge augumentation with autogenous cancellous bone marrow graft. J Oral Surg 32 : 773, 1974
  10. Botticelli D, Berglundhe T, Lindhe J : Hard tissue alterations following immediate implant placement in extraction site. J Clin Periodontol 31 : 820, 2004 https://doi.org/10.1111/j.1600-051X.2004.00565.x
  11. Davis WH et al : Transoral bone graft for atrophy of the mandible. J Oral Surg 28 : 760, 1970
  12. Nishibori M, Betts NJ, Salama H, Listgarten MA : Shortterm healing of autogenous and allogenic bone grafts after sinus augmentation: A report of 2 cases. J Periodontol 65 : 958, 1994 https://doi.org/10.1902/jop.1994.65.10.958
  13. Nevins M, Melonig JT : Enhancement of the damaged edentulous ridge to receive dental implants. A combination of allograft and Gore-Tex membrane: Int J Periodontics Restorative Dent 12 : 96, 1992
  14. Becker W, Becker BE, Caffesse R : A comparison of demineralized freeze-dried bone and autologous bone to induce bone formation in human extraction sockets: J Periodontol 69 : 414, 1998 https://doi.org/10.1902/jop.1998.69.4.414
  15. Brugnami F, Then PR, Moroi H, Leone CW : Histologic evaluation of human extraction sockets treated with demineralized freeze-dried bone allogragft(DFDBA) and cell occlusive membrane. J Periodontol 67 : 821, 1996 https://doi.org/10.1902/jop.1996.67.8.821
  16. Becker W, Urist M, Becker BE et al : Clinical and histological observation of sites implanted with intraoral autologous bone grafts or allografts. 15 human case reports. J Periodontol 67 : 1025, 1996 https://doi.org/10.1902/jop.1996.67.10.1025
  17. Periklis Proussaefs and Jaime Lozada : The use of resorbable collagen membrane in conjunction with autogenous bone graft and inorganic bovine mineral for buccal/labial alvelar ridge augmentation: A pilot study. J Prosth Dent 90(6) : 530, 2003 https://doi.org/10.1016/S0022-3913(03)00521-3
  18. Frame JW, Brady CL : Augmentation of an atrophic edentulous mandible by interpositional grafting with hydroxylapatite. J Oral Maxillofac Surg 42(2) : 8, 1984
  19. Gross J : Ridge preservation using HTR synthetic bone following tooth extraction: Gen Dent 43 : 364, 1995
  20. Bahat O, Deeb C, Golden T, Komamyckyi O : Preservation of ridge utilizing hydroxyapatite: Int J Periodontics Restorative Dent 7(6) : 35, 1987
  21. Paulo M Camargo, Lekovic V, Barrie K. et al : Influence of bioactive glass on changes in alveolar process dimensions after exodontia. Oral Surg Oral Med Oral Pathol Oral Radiol & Endod 90(5) supple 5 : 581, 2000 https://doi.org/10.1067/moe.2000.110035
  22. Boyne PJ : Use of HTR in tooth extraction sockets to maintain alveolar ridge height: Gen Dent 43 : 470, 1995
  23. Scheer P, Boyne PJ : Maintenance of alveolar bone through implantation of bone graft substitutes in tooth extraction socket. J Am Dent Assoc 114 : 594, 1987
  24. Nemcovsky C, Serfaty V : Alveolar ridge preservation following tooth extraction of maxillary anterior teeth. Report on 23 consecutive cases. J Periodontol 67 : 390, 1996 https://doi.org/10.1902/jop.1996.67.4.390
  25. Zvi Artzi, Calos EN : The application of deproteinized bovine bone mineral for ridge preservation prior to implantation: Clinical and histological observation in a case report. J Periodontol 69 : 1062, 1998 https://doi.org/10.1902/jop.1998.69.9.1062
  26. Lekovic V, Camargo PM, Klokkevold PR et al : Preservation of alveolar bone in extraction socket using polylactic acid membranes. J Periodontol 69 : 1044, 1998 https://doi.org/10.1902/jop.1998.69.9.1044
  27. Howell TH, Fiorellini J, Jones A, Alder M : a feasibility study evaluating rh BMP-2/absorbable collagen sponge device for local alveolar ridge preservation or augumentation. international journal of Periodontology and Restorative Dentistry 17 : 125, 1997
  28. Glovanni S, Salvatore B, Giovanna L, Adriano P : Ridge preservation following tooth extraction using a polylactide and polyglycolide sponge as space filler: A clinical and histological study in humans. Clin Oral Implant Res 14(5) : 651, 2003 https://doi.org/10.1034/j.1600-0501.2003.00970.x
  29. Laurencin CT, Lane JM : Poly-lactide acid and poly-glycolide acid: orthopedic and surgery applications. In: Tissue Engineering: Application in Maxillofacial Surgery and Periodontics, 325339. Chicago: Quintessence Publishing Co. Inc
  30. Holland SJ, Tighe BJ, Gould PL : Polymers for biodegradable medical device. I. The potential of polyesters as controlled macromolecular release system. Journal of Controlled Release 4 : 155, 1986 https://doi.org/10.1016/0168-3659(86)90001-5
  31. Tayapongsak P, O'Brien DA, Monteiro CB, Arceo-Diaz LL : Autologous fibrin adhesive in mandibular reconstruction with particulate cancellous bone and marrow. J Oral MaxillofacSurg 52 : 161, 1994 https://doi.org/10.1016/0278-2391(94)90401-4
  32. Johnson K : A study of the dimensional changes occurring in the maxilla following tooth extraction. Austral Dent J 14 : 241, 1969
  33. Eduardo Anitua : Plasma rich in growth factors: Preliminary results of use in the preparation of future sites for implants 14 : 529, 1999
  34. Fuerst G, Gruber R, Tangl S et al : Effect of platelet released growth factors and collagen type I on osseous regeneration of mandibular defects. A pilot study in minipigs. J Clin Periodontol 31 : 784, 2004
  35. Kugelburg CF, Ahlstorm U, Erison S et al : Periodontal healing after impacted lower third molar surgery in adolescents and adults. Int J Oral Maxillofac Surg 20 : 18, 1991
  36. McCall PA, Rosenfeld AL : Influence of residual ridge resorption patterns on implant fixture placement and tooth position Int J Periodic Restorative Dent 11 : 8, 1991
  37. Lam RV : Effect of root implant on resorption of residual ridges. J Prosthet Dent 27 : 311, 1972
  38. Strong SM, Callen DP : Restoration of the resorbed maxilla. Practical Periodont36. Sobolik CF: Alveolar bone resorption. J Prosthet Dent 10 : 612, 1960
  39. Atwood DA : Postextraction changes in the adult mandible as illustrated by microradiographs of midsagittal sections and serial cephalometric roentgenograms. J Prosthet Dent 13 : 810, 1963
  40. Atwood DA : Reduction of residual ridges: A major oral disease entity. J Prosthet Dent 26 : 266, 1971
  41. Atwood DA, Coy WA : Clinical, cephalometric and densitometric study of reduction of residual ridges. J Prosthet Dent 26 : 280, 1971
  42. Calsson GE, Bergman B, Hedegard B : Changes in contour of the maxillary alveolar process under immediate denture. Acta Odontol Scand 25 : 45, 1967
  43. Misch CE: Contemporary implant dentistry. Mosby St. Louis, 1993;p 72-428
  44. Kusiak JF, Zins JE, Whitaker LA : The early revascularization of membranous bone. Plast Reconst Surg 76 : 510, 1985
  45. Wolfe SA : Autogenous bone graft versus alloplastic material in maxillofacial surgery. Clin Plast Surg 9 : 539, 1982
  46. Marx RE, Kline SN, Johnson RP, Malinin TI : The use of Freeze-dried allogenic bone in oral and maxillofacial surgery. J Oral Surg 39 : 264, 1981
  47. Garraway R, Young WG, Dale T, Harbrow D, Bartold PM : An assessment of the osteoinductive potential of commercial demineralized freeze dried bone in the murine thigh muscle and implantation model. J Periodontol 69 : 1325, 1998
  48. Klinge B, Alberius P, Isaksson S, Jonsson J : Osseous response to implanted natural bone mineral and synthetic hydroxyapatite ceramics in the repair of experimental skull bone defects. J Oral Maxillofac Surg 50 : 241, 1992
  49. Roger RT, Barret SS, Calveston T : Grafting mandibular third molar extraction sites: A comparision of bioactive glass to a nografted site. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 94 : 413, 2002
  50. Cohen RE, Mullarkey RH, Nole B et al : Phenotypic characteization of mononuclear cells following anorganic bovine bone implantation in rats. J Periodontol 65 : 1008, 1994
  51. Anthony IJ, Michael SB : Comparison of 3 bone substitutes in canine extraction sites. J Oral Maxillofac Surg 60 : 53, 2002
  52. Boyne PJ : Osseous reconstruction of the maxilla and the mandible surgical techniques using titanium mesh and bone mineral: Carol Stream IL: Quintentessence Publishing 1996, p.87
  53. Pinholt EM, Bang G, Haanaes HR : Alveolar ridge augmentation in rats by Bio-oss. Scandinavian J Dent Res 99 : 154, 1991
  54. human tooth extraction sockets implanted with bioabsorbable polylactic-polyglycolic acids(PLGA) copolymer root replicas: A clinical, radiographic, and histologic follow up report of 8 cases. Oral Surg Oral Med Oral Pathol Oral Radio Endod 97 : 559, 2004
  55. Bowen-Pope DF, Vogel A, Ross R : Production of plateletderived growth facto-like molecules, reduced expression of platelet-derived growth factor receptors accompany transformation by a wide spectrum of agents. Proc Nat Acad Sci USA 81 : 2396, 1984 https://doi.org/10.1073/pnas.81.8.2396
  56. Greenlagh DG : The role of growth factors in wound healing. J Trauma 41 : 159, 1996
  57. Marx RE, Carlson ER, Eichstedt RM, Schimmele SR, Strauss JE, Georgeff KR : Platelet-rich plasma: Growth factor enhancement for bone grafts. Oral Surg Oral Med Oral Pathol 85 : 638, 1998
  58. Antonaides HN : Human platelet derived growth factor: Purification of PDGF-I and PDGF-II and separation of their reduced sub-units. Proc Nat Acad Sci USA 78 : 7314, 1981
  59. Roberts AB, Spron MB : Physiological actions and clinical applications of transforming growth factor-beta. Growth Factors 8 : 1, 1993
  60. Miyazono K, Ten-Dijke P, Ichiyo H, Heldin CH : Receptors for transforming growth factor-beta. Adv Immunol 55 : 181, 1994
  61. Pierce GF, Tarpley J, Yanagihara D : PDGF-BB, TGF-$\beta$1 and basic FGF in dermal wound healing: Neovessel and matrix formation and cessation of repair. Am J Pathol 140 : 1375, 1992
  62. Mohan S, Baylink DJ : Bone growth factors: Clin Orthop 263 : 30, 1991
  63. Canalis E, Centrella M, Busch W, Mccarthy TL : Insulinlike growth factor I mediates selective anabolic effects of parathyroid hormone in bone cultures. J Clin Invest 83 : 60, 1989
  64. Fuerst G, Gruber R, Tangle S et al : Effect of platelet released growth factors and collagen type I on osseous regeneration of mandibular defects. J Clin Periodontol 31 : 784, 2004