Transactions of the Korean Society of Mechanical Engineers A (대한기계학회논문집A)

The Korean Society of Mechanical Engineers (대한기계학회)
권호 표지
DOI QR코드

DOI QR Code

Development of an Injection Molded Disposable Chaotic Micromixer: Serpentine Laminating Micromixer (II) - Fabrication and Mixing Experiment -

사출 성형된 일회용 카오스 마이크로 믹서의 개발: 나선형 라미네이션 마이크로 믹서 (II) - 제작 및 혼합 실험 -

  • Published : 2005.10.01
Download PDF
⟨ Previous Next ⟩

Abstract

In this paper, Part II, we realized the Serpentine Laminating Micromirer (SLM) which was proposed in the accompanying paper, Part I, by means of the injection molding process in mass production. In the SLM, the higher level of chaotic mixing can be achieved by combining two general chaotic mixing mechanisms of splitting/recombination and chaotic advection by the successive arrangement of 'F'-shape mixing units in two layers. Mold inserts for the injection molding process of the SLM were fabricated by SU-8 photolithography and nickel electroplating. The SLM was realized by injection molding of COC (cyclic olefin copolymer) with the fabricated mold inserts and thermal bonding of two injection molded COC substrates. To compare the mixing performance, a T-type micromixer was also fabricated. Mixing performances of micromixers were experimentally characterized in terms of an average mixing color intensity of a pH indicator, phenolphthalein. Experimental results show that the SLM has much better mixing performance than the I-type micromixer and chaotic mixing was successfully achieved from the SLM over the wide range of Reynolds number (Re). The chaotic micromixer, SLM proposed in this study, could be easily integrated in Micro-Total-Analysis- System , Lab-on-a-Chip and so on.

Keywords

References

  1. Kim, D.S., Lee, S.H., Kwon, T.H. and Ahm, C.H., 2005, 'Development of an Injection Molded Disposable Chaotic Micromixer: Serpentine Laminating Micromixer (I) Design and Numerical Analysis,' Trans. of the KSME (A), Vol. 29, No. 10, pp. 1289-1297 https://doi.org/10.3795/KSME-A.2005.29.10.1289
  2. Auroux, P.-A, Iossifidis, D., Reyes, D.R. and Manz, A, 2002, 'Micro Total Analysis Systems. 2. Analytical Standard Operations and Applications,' Anal. Chem., Vol. 74, pp. 2637-2652 https://doi.org/10.1021/ac020239t
  3. Hong, C.-C., Choi, J.-W. and Ahn, C.H., 2004, 'A Novel In-Plane Passive Microfluidic Mixer with Modified Tesla Structures,' Lab Chip, Vol. 4, pp. 109-113 https://doi.org/10.1039/b305892a
  4. Liu, R.H., Stremler, M.A., Sharp, K.V., Olsen, M.G, Santiago, J.G, Adrian, R.J., Aref, H. and Beebe, D.J., 2000, 'Passive Mixing in a Three-Dimensional Serpentine Microchannel,' J. Microelectromech. Syst., Vol. 9, pp. 190-197 https://doi.org/10.1109/84.846699
  5. Stroock, A.D., Dertinger, S.K.W, Ajdari, A., Mezic, I., Stone, H.A. and Whitesides, G.M., 2002, 'Chaotic Mixer for Microchannels,' Science, Vol. 295, pp. 647-651 https://doi.org/10.1126/science.1066238
  6. Kim, D.S., Lee, S.W, Kwon, T.H. and Lee, S.S., 2004, 'A Barrier Embedded Chaotic Micromixer,' J. Micromech. Microeng., Vol. 14, pp. 798~805 https://doi.org/10.1088/0960-1317/14/6/006
  7. Bertsch, A., Heimagartner, S., Cousseau, P. and Renaud, P., 2001, 'Static Micromixers Based on Large-Scale Industrial Mixer Geometry,' Lab Chip, Vol. 1, pp. 56-60 https://doi.org/10.1039/b103848f
  8. Kim, D.S., Lee, I.H., Kwon, T.H. and Cho, D.-W., 2004, 'Barrier Embedded Kenics Micromixer,' J. Micromech. Microeng., Vol. 14, pp. 1294-1301 https://doi.org/10.1088/0960-1317/14/10/002
  9. Branebjerg, J., Gravesen, P. and Krog, J.P., 1996, 'Fast Mixing by Lamination,' MEMS 96, San Diego, CA, February 11-15, pp. 441-446
  10. Schwesinger, N., Frank, T. and Wurmus, H., 1996, 'A Modular Microfluid System with an Integrated Micromixer,' J. Micromech. Microeng., Vol. 6, pp. 99-102 https://doi.org/10.1088/0960-1317/6/1/023
  11. Schonfeld, F., Hessel, V. and Hofmann, C., 2004, 'An Optimized Split-and-Recombine Micro-mixer with Uniform 'Chaotic' Mixing, Lab Chip, Vol. 4, pp. 65-69 https://doi.org/10.1039/b310802c
  12. Lee, S.H., Han, J., Kim, D.S., Kwon, T.H., Hwang, C.J., Heo, Y.M. and Ahn, C.H., 2004, 'A High Precision Self-assembly Technique for Multilayer Polymer Lab-on-a-chip,' Proc. of TAS 2004, Sweden, September 2004, Vol. 2, pp. 413-415
  13. Becker, H. and Gartner, C., 2000, 'Polymer Microfabrication Methods for Microfluidic Analytical Applications,' Electrophoresis2000, Vol. 21, pp. 12-26 https://doi.org/10.1002/(SICI)1522-2683(20000101)21:1<12::AID-ELPS12>3.0.CO;2-7
  14. Xia, Y. and Whitesides, G.M., 1998, 'Soft Lithography,' Angew. Chem. Int. Ed., Vol. 37, pp. 550-575 https://doi.org/10.1002/(SICI)1521-3773(19980316)37:5<550::AID-ANIE550>3.0.CO;2-G