Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
권호 표지

The Efficacy of Albendazole, Fenbendazole and Metronidazole for Treatment of Canine Giardia

개의 Giardia 감염에 따른 Albendazole, Fenbendazole, Metronidazole의 치료 효과

  • Published : 2005.09.01
Download PDF
⟨ Previous Next ⟩

Abstract

Current treatments for canine Giardia infections include albendazole, fenbendazole and metronidazole in the most cases. To compare efficacy of these antimicrobial drugs for treating naturally infected giardiasis in dogs, we used the zinc sulfate concentration technique(ZSCT) to figure out naturally infected with Giardia. In this study, feces were collected from 150 asymptomatic dogs at a kennel, 28 asymptomatic Giardia infected dogs were used by the allocated four group to receive albendazole(group A, 25 mg/kg, PO, bid, 7 days), fenbendazole(group F, 50 mg/kg, PO, sid, 7 days), metronidazole (group M, 50 mg/kg, PO, sid, 7 days), nontreated control(group NC) respectively. Fecal samples from each dog were examined for Giardia cysts within 3 days of the last treatment. Giardia cysts were not detected in the feces of any dog in group F. Cysts were detected in the feces 1 of 7 dogs in group A or in the feces 2 of 7 dogs in group M. In the group NC, cysts were detected in the feces of 7 of 7 dogs. Finally, there was significant difference for efficacy between antimicrobial drugs against Giardia in dogs. Fenbendazo1e is the most efficacy to have giardiacidal activity.

Keywords

References

  1. Barr SC, Bowman DD, Heller RL. Efficacy of fenbendazole against giardiasis in dogs. Am J Vet Res 1994; 55: 988-990
  2. Barr SC, Bowman DD, Heller RL, Erb HN. Efficacy of albendazole against giardiasis in dogs. Am J Vet Res 1993; 54: 926-928
  3. Caylor KB, Cassimatis MK. Metronidazole neurotoxicosis in two cats. J Am Anim Hosp Assoc 2001; 37: 258-262
  4. Chavaz B, Espinosa-Cantellano M, Cedillo Rivera R, Ramirez A, Martinez-Palomo A. Effects of albendazole on Entamoeba histolytica and Giardia lamblia trophozoites. Arch Med Res 1992; 23: 63-67
  5. Dow Sw. Management of anaerobic infections. Vet Clin North Am Sm Anim Pract 1988; 18: 1167-1182
  6. Dow SW, LeCouteur RA, Poss ML, Beadleston D. Central nervous system toxicosis associated with metronidazole treatment of dogs: five cases (1984-1987). J Am Vet Med Assoc 1989; 195: 365-368
  7. Edlind TD, Hang TL, Chakraborty PR. Activity of the anthelmintic benzimidazole against Giardia lamblia in vitro. Trans R Soc Trop Med Hyg 1990; 24: 1408-1411
  8. Georgi JR, Georgi ME, Theodorides VJ. Parasitology for veterinarians. 5th ed. Philadelphia: WB Saunders Co. 1990: 268-269
  9. Goldman P. Drug therapy, metronidazole. N Eng J Med 1980; 303: 1212-1218 https://doi.org/10.1056/NEJM198011203032106
  10. Hall A. Quamrun N. Albendazoleas a treatment for infection with Giardia lambia in children Bangladesh. Trans R Soc Trop Med Hyg 1993; 87: 84-86 https://doi.org/10.1016/0035-9203(93)90435-S
  11. Hill SL, Cheney JM, Taton-Allen GF, Reif JS, Bruns C, Lappin MR. Prevalence of enteric zoonotic organisms in cats. J Am Vet Med Assoc 2000; 216: 687-692 https://doi.org/10.2460/javma.2000.216.687
  12. Horton RJ. Benzimidazoles in a wormy world. Parasitol Today 1990; 6: 106 https://doi.org/10.1016/0169-4758(90)90225-S
  13. Jacobs SR, Forrester CPR, Yang J. A survey of the prevalence of Giardia in dogs presented to Canadian veterinary practices. Can Vet J 2001; 42: 45-46
  14. Jergens AE. Inflammatory bowel disease: current perspectives. Vet Clin North Am Sm Anim Pract 1999; 29: 501-521
  15. Kirkpatrick CE. Epizootiology of endoparasitic infections in pet dogs and cats presented to a veterinary teaching hospital. Vet Parasitol 1988; 30: 113-124 https://doi.org/10.1016/0304-4017(88)90158-6
  16. Lacey E. Mode of action of benzimidazoles. Parasitol Today 1990; 6: 112-115 https://doi.org/10.1016/0169-4758(90)90227-U
  17. Leib MS, Zajac AM. Giardia: diagnosis and treatment. In: Curent Veterinary Therapy XII. Small Animal Practice. Philadelphia: WB Saunders Co. 1995: 716-719
  18. Marshall MM, Naumovitz D, Ortega Y, Sterling CR. Waterborne protozoan pathogens. Clin Microbiol Rev 1997; 10: 67-85
  19. Meloni BP, Thompson RCA, Reynoldson JA, Seville P. Albendazole: a more effective antigiardial agent in vitro than metronidazole or tinidazole. Trans R Soc Trop Med Hyg 1990; 24: 375-379
  20. O'Handley RM, Olson ME, McAllister TA, Morck DW, Jelinski M, Royan G, Cheng KJ. Efficacy of fenbendazole for treatment of giardiasis in calves. Am J Vet Res 1997; 4: 384-388
  21. Oxberry ME, Thompson RC, Reynoldson JA. Evaluation of the effect of albendazole and metronidazole on the ultrastructure of Giardia duodenalis, Trichomonas vaginalis and Spiro nucleus muris using transmission electron microscopy. Int J Parasitol 1994; 24: 695-703 https://doi.org/10.1016/0020-7519(94)90123-6
  22. Papich MG. Antiulcer therapy. Vet Clin North Am Sm Anim Pract 1993; 23: 497-512
  23. Spain CV, Scarlet JM, Wade SE, McDonough P. Prevalence of enteric zoonotic agents in cats less than 1 year old in central New York State. J Vet Intern Med 2001; 15: 33-38 https://doi.org/10.1892/0891-6640(2001)015<0033:POEZAI>2.3.CO;2
  24. Taboada J, Dimski DS. Hepatic encephalopathy: clinical signs, pathogenesis, and treatment. Vet Clin North Am Sm Anim Pract 1995; 25: 337-355
  25. Wolfe MS. Giardiasis. Clin Microbiol Rev 1992; 5: 93-100
  26. Xiao L, Saeed K, Herd RP. Efficacy of albendazole and fenbendazole against Giardia infection in cattle. Vet Parasitol 1996; 61: 165-170 https://doi.org/10.1016/0304-4017(95)00802-0
  27. Zimmer JF, Burrington DB. Comparison of four protocols for the treatment of canine giardiasis. J Am Anim Hosp Assoc 1986; 22: 168-172