Immunosuppressive Activity of Wogonin from Scutellaria Radix on DNFB-induced Delayed Type Hypersensitivity in Mice

마우스에서 황금 유래 Wogonin의 Th1과 Th2 사이토가인 조절 효과

  • Kim Young Jun (Department of Skin & Beauty, Seojeong College) ;
  • Lee Jeong Chi (Department of Skin & Beauty, Seojeong College) ;
  • Kim Hong Yong (Department of Skin & Beauty, Seojeong College) ;
  • Xie Guanghua (Department of General Surgery, Affiliated Hospital of Yanbian University College of Medicine) ;
  • Yun Yong Gab (Department of Oriental medical prescription, Wonkwang University) ;
  • Jang Seon Il (Department of Skin & Beauty, Seojeong College)
  • 김용준 (서정대학 피부미용과) ;
  • 이정치 (서정대학 피부미용과) ;
  • 김홍용 (서정대학 피부미용과) ;
  • 설광화 (중국 연변대학교 의과대학 일반외과) ;
  • 윤용갑 (원광대학교 한의과대학 방제학교실) ;
  • 장선일 (서정대학 피부미용과)
  • Published : 2005.08.01

Abstract

In the present study, wogonin, a major flavone isolated from Scutellaria Radix were examined for its imunosuppressive activity on the 2,4-dinitro-fluorobenzene (DNFB)-induced delayed type hypersensitivity (DTH) in C3H/HeN mice. This compound inhibited selectively $TNF-\alpha$ and IL-4, but not IL-6, IL-10 and $IFN-\gamma$ on DNFB-induced Th1 and Th2 cytokines in a concentration-dependent manner. Interestingly, this compound increased the expression of heme oxygenase-1 (HO-1) in a concentration-dependent manner The above results reveal that wogonin possesses anti-inflammatory, humoral and cellular immunomodulatory, and stress reducing activities on the DNFB-induced DTH in mice and these properties may contribute to the anti-atopic dermatitis activity of Scutellaria Radix.

Keywords

References

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