Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Antitumor and Anti-metastatic Effect of Mineral Powder

광물석분의 항암 및 항전이 효과에 관한 연구

  • 송규용 (대전대학교 한의과대학 병리학교실) ;
  • 배기환 (대전대학교 한의과대학 병리학교실) ;
  • 명창선 (대전대학교 한의과대학 병리학교실) ;
  • 김문일 (충남대학교 약학대학) ;
  • 박용진 (백남한의원) ;
  • 윤미영 (대전대학교 한의과대학 병리학교실) ;
  • 김동희 (대전대학교 한의과대학 병리학교실)
  • Published : 2005.08.01
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Abstract

Antitumor and anti-metastatic effects of mineral powder(MP) were studied. In the present study, MP did not exhibit the any cytotoxic activity against leukemic cells such as L1210 and U937 tumor cell lines in vitro. Also, MP did not exhibit the any cytotoxic activity against solid cells such as A549 and B16-BL6 tumor cell lines in vitro. However, in vivo, MP exhibit a significant antitumor activity in BDF1 mice bearing Lewis lung carcinoma cells(LLC) with inhibition rates of 46 and $23\%$ at 200 and 100 mg/kg/day, respectively. Furthermore, in pulmonary colonization assay, MP exhibit the inhibitory effect of tumor metastasis. From these results, it was concluded that MP had antitumor and anti-metastatic activity suggesting its application for the prevention and treatment of cancer.

Keywords

References

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