Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Cytotoxic Saponins from the Root of Dipsacus asper Wall

  • Hung Tran Manh (College of Pharmacy, Chungnam National University) ;
  • Jin WenYi (College of Pharmacy, Chungnam National University) ;
  • Thuong Phuong Thien (College of Pharmacy, Chungnam National University) ;
  • Song Kyung Sik (College of Agriculture and Life Science, Kyungpook National University) ;
  • Seong Yeon Hee (College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University) ;
  • Bae KiHwan (College of Pharmacy, Chungnam National University)
  • Published : 2005.09.01
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Abstract

Cytotoxic activitiy of seven hederagenin saponins isolated from the root of Dipsacus asper were investigated in vitro against L1210, HL-60 and SK-OV-3 tumor cell lines by the MTT method. $3-O-\alpha-L-rhamnopyranosyl-(1{\rightarrow}2)-\alpha-L -arabinopyranosyl$ hederagenin (2),\;$3-O-\beta-D­xylopyranosyl-( 1{\rightarrow}3)-\alpha-L-Rhamnopyranosyl-(1{\rightarrow}2)-\alpha-L -arabinopyranosyl$ hederagenin (6) and $3-O-\beta-D-glucopyranosyl-(1{\rightarrow}3)-\alpha-L-rhamnopyranosyl-( 1{\rightarrow}2)-\alpha-L-arabinopyranosyl$ hederagenin (7) exhibited the potent cytotoxicity against the three tumor cell lines with $IC_{50}$ values ranging from 4.7 to 8.7 ${\mu}g/mL$, with the exception of compound 7, which exhibited weak cytotoxic activity against SK-OV-3 $(IC_{50}\;22.5\;{\mu}g/mL)$. Other compounds did not exhibit any cytotoxic activity $(IC_{50}>30{\mu}g/mL)$.

Keywords

References

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