생명과학회지 (Journal of Life Science)

  • 제15권4호
  • /
  • Pages.619-625
  • /
  • 2005
  • /
  • 1225-9918(pISSN)
  • /
  • 2287-3406(eISSN)
한국생명과학회 (Korean Society of Life Science)
권호 표지
DOI QR코드

DOI QR Code

Streptozotocin-유발 당뇨쥐에 대한 함초 요구르트의 생리학적 효능

Physiological Effect of Hamcho Yogurt on Streptozotocin-Induced Diabetic Rats

  • 차재영 (동아대학교 응용생명공학부) ;
  • 전병삼 (㈜바이오허브 부설연구소) ;
  • 김범규 (㈜바이오허브 부설연구소) ;
  • 강호영 (부산대학교 생명과학부) ;
  • 조영수 (동아대학교 응용생명공학부)
  • 발행 : 2005.08.01
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

함초 추출물 분말을 첨가하여 유산 발효시킨 함초 요구르트를 streptozotocin-유발 당뇨쥐에 투여하여 항당뇨효과 및 콜레스테롤 저하 효과를 규명하기 위하여 3주간 실험하였다. 당뇨 대조군에 비해 함초 요구르트 투여군에서 혈당치 농도 및 식이 섭취량이 현저히 감소하였다. 경구당부하 실험에서도 당뇨 대조군에 비해 함초 요구르트 투여군에서 현저한 혈당상승 억제작용을 나타내었다. 당뇨쥐에 함초 요구르트와 일반 요구르트 섭취에 의해 혈중 총 콜레스테롤 농도 감소와 더불어 동맥경화지수도 감소하였다. 따라서, 함초 요구르트에 의한 혈당치 및 콜레스테롤 농도 감소효과는 고혈당증 및 고 콜레스테롤 혈중에도 유익한 작용을 할 수 있는 기능성식품 개발 가능성이 있음을 시사하였다.

The present study was undertaken to investigate the hypoglycemic effect of Hamcho yogurt fermented by lactic acid bacteria containing Hamcho (Salicornia herbacea) extract powder in streptozotocin(STZ)-induced diabetic rats for 3 week period. The Hamcho yogurt given to the STZ-diabetic rats had significant effect in lowering the serum glucose concentrations and food intakes compared to the STZ-diabetic rats. The Hamcho yogurt administration increased the tolerance to oral glucose loading in the STZ-diabetic rats. The Hamcho yogurt and yogurt given to the STZ-diabetic rats were significantly decreased the serum total cholesterol concentration and the atherogenic index. Based on the beneficial effect against the blood glucose and cholesterol levels, we suggest the Hamcho yogurt can be used as functional food for the hypoglycemic and hypocholesterolemic effects.

키워드

참고문헌

  1. AIarcon-Aguilara, F. J., R. Rornan-Ramos, S. Perez-Gutierrez S. 1998. Study of the anti-hyperglycemic effect of plants used as antidiabetics. J Ethnapharmacol 61, 101-110 https://doi.org/10.1016/S0378-8741(98)00020-8
  2. Anderson, J. W., S. E. Gilliland. 1999. Effect of fermented milk (yogurt) containing Lactobacillus acidophilus L1 on serum cholesterol in hypercholesterolemic humans. J Am Coli Nutr 18, 43-50 https://doi.org/10.1080/07315724.1999.10718826
  3. Bang, M. A., H. A. Kim, Y. J. Cho. 2002. Hypoglycemic and antioxidant effect of dietary Hamcho powder in streptozotocin-induced diabetic rats. J Korean Soc Food Sci Nutr 31, 840-846 https://doi.org/10.3746/jkfn.2002.31.5.840
  4. Castelli, W. P., R. J. Garrison, P. W. F. Wilson, R. D. Abborr, S. Kalousdian, W. B. Kannel. 1989. Incidence of coronary heart disease and lipoprotein cholesterol levels. The Framingham study. JAMA 256, 2835-2845 https://doi.org/10.1001/jama.256.20.2835
  5. Cha, J. Y., S. J. Jeong, Y. S. Cho. 2001. Effect of chicory root extract on cholesterol metabolism in rats. Agric Chem Biotechnol 44, 131-134
  6. Cha, J. Y., B. S. Jeon, J. W. Park, G. G. Shin, B. K. Kim, H. K. Kim, Y S. Cho. 2004. Hypoglycemic effect of mushroom fermented milk in streptozotocin induced diabetic rats. Korean J Life Sci 14, 676-682 https://doi.org/10.5352/JLS.2004.14.4.676
  7. Cha, J. Y, B. S. Jeon, J. W. Park, B. K. Kim, C. Y. Jeong, J. S. Ryu, C. K. Choi, Y. S. Cho. 2004. Hypocholesterolemic effect of yogurt supplemented Saliconia herbacea extract in cholesterol-fed rats. J Life Sci 14, 747-751 https://doi.org/10.5352/JLS.2004.14.5.747
  8. Dumelod, B. D., R. P. Ramirez, C. L. Tiangson, E. B. Barrios, L. N. Panlasigui. 1999. Carbohydrate availability of arroz caldo with lambda-carrageenan. Int J Food Sci Nutr 50, 283-289 https://doi.org/10.1080/096374899101166
  9. Duncan, D. B. 1957. Multiple range test for correlated and heteroscedastic means. Biometrics 13, 164-176 https://doi.org/10.2307/2527799
  10. Gray, A. M., P. R. Flatt. 1998. Insulin-releasing and insulin-like activity of Agaricus campestris (mushroom). J Endocrinol 157, 259-266 https://doi.org/10.1677/joe.0.1570259
  11. Grover, J. K., S. Yadav, V. Vats. 2002. Medicinal plants of India with anti-diabetic potential. J Ethnopharmacol 81, 81-100 https://doi.org/10.1016/S0378-8741(02)00059-4
  12. Han, S. K., M. S. Kim, B. S. Pyo. 2003. Antioxidative effect of glasswort (Salicornia herbacea L.) on the lipid oxidation of pork. Korean J Food Sci Ani Resour 23, 46-49
  13. Han, S. K., M. S. Kim. 2003. Antioxidative effect of Salicornia herbacea L. grown in closed sea beach. J Korean Soc Food Sci Nutr 32, 207-210 https://doi.org/10.3746/jkfn.2003.32.2.207
  14. Jeong, C. Y., J. S. Ryu, C. K. Choi, B. S. Jeon, J. W. Park, B. K. Kim, G. G. Shin, D. W. Bea, J. Y. Cha. 2004. Supplemented effect of Saliconia herbacea extract powder on preparation and quality characteristics of fermented milk product. J Life Sci 14, 788-793 https://doi.org/10.5352/JLS.2004.14.5.788
  15. Jeon, B. S., J. W. Park, B. K. Kim, H. K. Kim, T. S. Jung, J. R. Hahm, D. R. Kim, Y. S. Cho, J. Y. Cha. Fermented mushroom milk supplemented dietary fiber prevents the onset of obesity and hypertriglyceridemia in Otsuka LongEvans Tokushima Fatty (OLETF) rats. Diabetes Obesity Met 2005(in press)
  16. Jeon, B. S., J. W. Park, G. G. Shin, B. K. Kim, H. K. Kim, Y. S. Cho, J. Y. Cha. 2004. Effect of fermented mushroom milk on hyperlipidemia and hepatic injury in streptozotocin-induced diabetic and Zucker diabetic fatty rats. Food Sci Biotenol 13, 576-580
  17. Jo, Y. C., J. H. Ahn, S. M. Chon, K. S. Lee, T. J. Bea, D. S. Kang. 2002. Studies on pharmacological effects of glasswort (Salicornia herbacea L.). Korean J Medicinal Corp Sci 10, 93-99
  18. Kawase, M., H. Hashimoto, M. Hosoda, H. Morita, A. Hosono. 2000. Effect of administration of fermented milk containing whey protein concentrate to rats and healthy men on serum lipid and blood pressure. J Dairy Sci 83, 255-263 https://doi.org/10.3168/jds.S0022-0302(00)74872-7
  19. Kiho, T., H. Morimoto, M. Sakushima, S. Usui, S. Ukai. 1995. Polysaccharides in fungi. XXXV. Anti diabetic activity of an acidic polysaccharide from the fruiting bodies of Tremella fuciformis. Bioi Pharm Bull 18, 1627-1629 https://doi.org/10.1248/bpb.18.1627
  20. Kimura, Y., K. Watanabe, H. Okuda. 1996. Effects of soluble sodium alginate on cholesterol excretion and glucose tolerance in rats. J Ethnopharmacol 54, 47-51 https://doi.org/10.1016/0378-8741(96)01449-3
  21. Lamela, M., J. Anca, R. Villar, J. Otero, J. M. Calleja. 1989. Hypoglycemic activity of several seaweed extracts. J Ethnopharmacol 27, 35-43 https://doi.org/10.1016/0378-8741(89)90075-5
  22. Lee, J. J., H. Y. Yi, J. W. Yang, J. S. Shin, J. H. Kwon, C. W. Kim. 2003. Characterization of streptozotocin-induced diabetic rats and pharmacodynamics of insulin formulations. Biosci Biotechnol Biochem 67, 2396-2401 https://doi.org/10.1271/bbb.67.2396
  23. Lee, K. S., Y. S. Choi, J. S. Seo. 2004. Sea tangle supplementation lowers blood glucose and supports antioxidant systems in streptozotocin-induced diabetic rats. J Med Food 7, 130-135 https://doi.org/10.1089/1096620041223996
  24. Lee, K. S., J. S. Seo, Y. S. Choi. 1998. Effect of sea tangle and hypoglycemic agent on lipid metabolism in diabetic rats. J Korean Soc Food Sci Nutr 27, 960-967
  25. Mann, G. V., A. Spoerry. 1974. Studies of a surfactant and cholesteremia in the Maasai. Am J Clin Nutr 27, 464-469
  26. Mitsuoka, T. 2000. Significance of controlling intestinal flora in human health, In 'Intestinal Flora and Lifestyle-related Diseases' (in Japanese), ed. Mitsuoka, T, Japan Scientific Societies Press, Tokyo, pp. 1-40
  27. Ostman, E. M., H. G. M. Liljeberg, I. M. E. Bjorck. 2001. Inconsistency between glycemic and insulinemic responses to regular and fermented milk products. Am J Clin Nutr 74, 96-100
  28. Reddy, B. S., A. Rivenson. 1993. Inhibitory effect of Bifido-bacterium longum on colon, mammary, and liver carcinogenesis induced by 2-amino-3-methylimidazo [4,5-f] quinoline, a food mutagen. Cancer Res 53, 3914-3918
  29. Schneeman, B. O. 1999. Fiber, Inulin and oligofructose: similarities and differences. J Nutr 129, 14245-14275
  30. Sipola, M, P. Finckenberg, R. Korpela, H. Vapaatalo, M L. Nurminen. 2002. Effect of long-term intake of milk products on blood pressure in hypertensive rats. J Dairy Res 69, 103-111
  31. Swanston-Flatt, S. K., C. Day, P. R. Flatt, B. T. Gould, C. J. Bailey. 1989. Glycemic effects of traditional European plant treatments for diabetes: studies in normal and streptozotocin diabetic mice. Diabetes Res 10, 69-73
  32. Tabuchi, M, M. Ozaki, A. Tamura, N. Yamada, T. Ishida, M. Hosoda, A. Hosono. 2003. Antidiabetic effect of Lactobacillus GG in streptozotocin-induced diabetic rats. Biosci Biotechnol Biochem 67, 1421-1424 https://doi.org/10.1271/bbb.67.1421
  33. Taranto, M. P., M. Meddici, G. Perdigon, A. P. R. Holgado, G. F. Valdez. 1989. Evidence for hypocholesterolemic effect of Lactobacillus reuteri in hypercholesterolemic mice. J Dairy Sci 81, 2336-2340 https://doi.org/10.3168/jds.S0022-0302(98)70123-7
  34. Torsdottir, I., M. Alpsten, G. Holm, A. S. Sandberg, J. Tolli. 1991. A small dose of soluble alginate-fiber affects postprandial glycemia and gastric emptying in human with diabetes. J Nutr 121, 795-800
  35. Unno, T., K. Nagata, T. Horiguchi. 2002. Effects of green tea supplemented with indigestible dextrin on postprandial levels of blood glucose and insuline in human subjects. J Nutr Food 5, 31-39
  36. Yuan, Z., P. He, H. Takeuchi. 1998. Ameliorating effects of water-soluble polysaccharide from woody ear (Auricularia auricula-judae Quel.) in genetically diabetic KK-$A^{y}$ mice. J Nutr Sci Vitaminol (Tokyo) 44, 829-840 https://doi.org/10.3177/jnsv.44.829

피인용 문헌

  1. Antioxidant activities, production of reactive oxygen species, and cytotoxic properties of fractions from aerial parts of glasswort (Salicornia herbacea L.) vol.48, pp.6, 2016, https://doi.org/10.9721/KJFST.2016.48.6.574
  2. Effects of Enzymatic Hydrolysates from Hamcho (Salicornia herbacea L.) on Blood Glucose and Serum Lipid Composition in Streptozotocin-Induced Diabetic Rats vol.37, pp.2, 2008, https://doi.org/10.3746/jkfn.2008.37.2.170