생명과학회지 (Journal of Life Science)

  • 제15권4호
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  • Pages.595-599
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  • 2005
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  • 1225-9918(pISSN)
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  • 2287-3406(eISSN)
한국생명과학회 (Korean Society of Life Science)
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Helicobacter pylori에 의한 위세포독성 및 interleukin-8 생성에 미치는 무의 억제효과

Inhibitory Effect of Radish on Gastric Cell Toxicity and Interleukin-8 Production Induced by Helicobacter pylori

  • 손윤희 (동국대학교 의과대학 약리학교실 및 난치병한양방치료연구소) ;
  • 서정일 (동국대학교 의과대학 내과학교실) ;
  • 박인경 (동국대학교 의과대학 약리학교실 및 난치병한양방치료연구소) ;
  • 황철원 (한동대학교 생명공학부) ;
  • 김철호 (동국대학교 한의과대학 생화학분자생물학교실) ;
  • 남경수 (동국대학교 의과대학 약리학교실 및 난치병한양방치료연구소)
  • Shon Yun Hee (Department of Pharmacology, College of Medicine and Interactable Disease Research Center Dongguk University) ;
  • Suh Jeong Ill (Department of Internal Medicine, College of Medicine Dongguk University) ;
  • Park In Kyung (Department of Pharmacology, College of Medicine and Interactable Disease Research Center Dongguk University) ;
  • Hwang Cher Won (Department of Enviromental Microbiology, Handong University) ;
  • Kim Cheorl Ho (Department of Biochemistry and Molecular Biology, College of Oriental Medicine Dongguk University) ;
  • Nam Kyung Soo (Department of Pharmacology, College of Medicine and Interactable Disease Research Center Dongguk University)
  • 발행 : 2005.08.01
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초록

무(한국 품종 및 일본 품종)를 사용하여 H. pylori에 의한 위세포독성 및 IL-8생성에 미치는 영향을 살펴보았다. 그 결과 무는 H. pylori에 의한 위세포독성을 농도의존적으로$(2\~10 mg/ml)$ 억제하였으며 또한 위암세포인 KATO III에서 분비되는 IL-8의 생성을 억제시킴$(5\~10mg/ml)$을 알았다. 이러한 사실은 무가 H. pylori감염에 의한 위점막세포의 손상을 방지할 수 있음을 나타낸다.

The efforts of Korean and Japanese radishes on the viability and interleukin (JL)-8 production by Helicobacter pylori were investigated in human gastric epithelial cell. Cell viability was significantly decreased when they were incubated with H. pylori toxin (p <0.05, p<0.01 and p<0.005). Co-incubation with Korean or Japanese radish increased H. pylori toxin-inhibited cell growth in a concentration-dependent manner. The production of IL-8 was greatly increased in H. pylori-infected gastric epithelial cell in concentration- and time-dependent manners. The increased production of IL-8 was significantly inhibited by Korean (p<0.05 and p<0.01) or Japanese (p<0.05) radishes $(5\~10mg/ml)$. These results indicate that Korean and Japanese radishes have protective effects on H. pylori-inhibited cell growth and H. pylori-induced gastric mucosal cell inflammation by suppressing the production of inflammatory cytokine (IL-8) from gastric epithelial cell.

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피인용 문헌

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