Korean Journal of Plant Resources (한국자원식물학회지)

The Plant Resources Society of Korea (한국자원식물학회)
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Effect of Vegetal Complex Raw Food on Plasma Glucose and Lipid Composition in High Fat Diet-induced Diabetic Rats

식물류를 이용한 생식용 천연복합식품이 고지방 식이에 의한 당뇨병 유발쥐의 혈청 glucose함량 및 지질구성에 미치는 영향

  • Published : 2005.06.01
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Abstract

This experiment was conducted to develop and design a product that is convenient and helpful to both patients and ordinary people who want to maintain their health. In this experimentation, the experimental rat have been given with high fat food to induce Diabetes. Organic brown rice was given as their main energy source and natural complex food, most of materials were freeze-dried, was given to observe its effects on their glucose amount in the plasma. The results are as follows. During 28 days of basal diets, as observing their weight variations, normal group gained weights, but the natural complex food(NCF) groups lost their weights. As comparing the amount of neutral fat levels in the plasma between the diabetes group who just had basal group and one who had NCF, group with NCF groups' level was much lower than the other group who just had basal food. As comparing total cholesterol levels in the plasma, with diabetes group with basal food, $50\%$ and $100\%$ NCF groups' levels were lowered than that group. Regarding HDL-cholesterol level, all NCE groups had around 30mg/dl and there were not much fluctuation among groups. As for LDL-cholesterol level, the $100\%$ NCF group had the lowest level and showed almost the same as the normal group. The amounts of the glucose in the plasma were lowered in all NCF groups. Among those NCE groups, $100\%$ NCF group had 120mg/dl to reach almost the same as the normal group.

본 연구는 비만인과 당뇨병환자들이 간편하게 이용할 수 있는 특용식이를 개발하기 위하여 고지방식이를 급여하여 당뇨병을 유발시킨 쥐에게 유기농현미를 주요 에너지원으로 하고 각종 기능성 요소가 내재한다고 알려져 있는 50여종의 식품원료를 조성으로 한 분말형 식이를 급여한 후 혈장 glucose 농도 및 지질구성을 검토한 결과 다음과 같이 나타났다. 당뇨유발 후 28일동안 각 처리별 식이를 급여한 결과 정상군에서는 체중이 증가하였으나, 당뇨유발군 모두에서 감소했다. 당뇨유발군중에서는 특용식이 $100\%$ 처리군에서 체중감소가 가장 많았다. 혈장 중성지질총량은 대조군과 비교하여 특용식이 처리군 모두에서 하락하는 경향을 보였으며, 특히 특용식이 $50\%,\;100\%$에서는 정상군의 수준을 나타냈다. 혈장 총콜레스테롤량은 대조군과 비교하여 특용식이 $50\%,\;100\%$에서 하락하는 경향을 보여주었다. HDL-cholesterol량은 전 처리군에서 30mg/dl 대의 수치를 나타내었으며, 각 처리에 따른 일정한 변동경향을 볼 수 없었다. LDL-cholesterol량은 특용식이 $100\%$처리군에서 최저치를 나타내어 정상군의 수준을 나타내었으며, 여타 처리군들은 대조군과 유사한 수치를 유지하였다. 혈장glucose량은 특용식이 처리군 모두가 대조군 보다 낮은 경향을 나타냈다. 특히 특용식이 $100\%$처리군에서는 120mg/dl의 수치를 나타내어 정상수준의 범주였다.

Keywords

References

  1. Anderson, J.W., W.J.L. Chen. 1979. Plant fiber carbohydrate and lipid metabolism. Am. J. clin. Nutr. 32 : 346-363
  2. Anderson, J.W., J. Tietyen-dark. 1986. Dietary fiber: Hyperlipidemia, hypertension and coronary heart disease. Am. J. Gastroent 81 : 907-919
  3. Cameron-smith, D., R. Habito, M. Barnett, G.R. collier. 1997. Dietary guar gum improves insulin sensitivity in streptozotocin-induced diabetic rats. J. Nutr. 127 : 359-364
  4. Chait, A., D. Foster, T. Mazzone. 1984. In vivo stimulation of low-density lipoprotein degradation by insulin. Diabetes 33 : 333-338 https://doi.org/10.2337/diabetes.33.4.333
  5. Coulston, A.M., C.B. Hollenbeck. 1988. Source and amount of dietary carbohydrate in patients with non insulin-dependent diabetes mellitus. Top clin. Nutr. 3: 17-24
  6. Good man, H.O., Z.K. Shihabi. 1990. Supplimental taurine in diabetic rats : Effects on plasma glucose and triglycerides. Biochem Med Metab, Biol. 43 : 19
  7. Jeong, S.W. 1993. A study on Changes of glucose and lipid metabolism on high calorie diet-induced KK mouse. Thesis of master degree at seoul National University Graduate School
  8. Kennedy, L., J.W. Baynes. 1984. Non-enzymatic glycosylation and the chrinic complications of diabetes. Diabetologia 26 : 93-98
  9. Klein, R.I., M.F. Lopes-virella, J.A. Colwell. 1990. Enhancement of platelet aggregation by the glycosylated subfraction of low-density lipoprotein isolated from patients with insulindependent diabetes mellitus. Diabetes 39(Suppl. 1) : 173A
  10. Laako, M., K. Pyorala, H. Sarlund, E. Voutilainen. 1986. Lipid and lipoprotein abnormalities associated with coronary heart disease in patients with insulin-dependent diabetes mellitus. Arteriosclerosis 6(6) : 679-684 https://doi.org/10.1161/01.ATV.6.6.679
  11. Lee, H.S., M.S. Choi, Y.K. Lee, S.H. Park, YJ. Kim. 1996. A study on the development of high-fiber supplements for the diabetic pateints(l)-Effect of seaweed supplementation on the gastrointestinal function and diabetic symptom control in streptozotocin-induced diabetic rats. Korean J. Nutrition 29 : 236-295
  12. Lopes-Virella, M.F., R.L. Klein, T.J. Lycos, H.C. Stevenson, J.L. Witztum.1988. Glycosylation of lowdensity lipoprotein enhances cholestery ester synthesis in human monocyte-derived macrophage. Diahetes 37 : 550-557
  13. Madar, Z. 1983. Effect of brown rice and soybean dietary fiber on the control of glucose and lipid metabolism in diabetic rats. Amer J. clin. Nutr. 38 : 388-393
  14. Meenakshi, C., K. Latha Kumari, 1995. Shyamala Devi CS. Biochemical studies on the effect of s-l ,3-butanediol of diabetes induced rats. Indian J. physiol. pharamacol 39 : 145-148
  15. Odaka, H., T. Matsuo. 1992. Ameliorating effects of an intestinal disaccharidase inhibitor, Ao-128 streptozotocin-diabetic rats. J. Japanese Soc. Food Nutr. 45 : 33-38 https://doi.org/10.4327/jsnfs.45.33
  16. Overton, P.D., N. Furlonger, J.M. Beety, J. Chakraborty, J.A. Tredger, L.M. Morgan. 1994. The effects of dietary sugarbeet fibre and guar gum on lipid metabolism in wistar rats. Bri. J. Nutr. 72 : 385-395 https://doi.org/10.1079/BJN19940041
  17. Park, S.H., Y.K. Lee, H.S. Lee. 1994. The effects of dietary fiber teeding on gastrointestinal functions and lipid and glucose metabolism in streptozotocin-induced diabetic rats. Korean J. Nutrition 27 : 311322
  18. Saudek, C.D., N.L. Yong. 1981. Cholesterol metabolism in diabetes mellitus. Diabetes 30(supple.2) : 76-81 https://doi.org/10.2337/diab.30.2.S76
  19. Somogyi, A., P. Pusztai, J. Prech J, Feher. 1994. Hypothetical connection between diabetes mellitus and free radical reactions in arteriosclerosis. Orv. Hetii. 135 : 1815-1818
  20. Winkler, R., M. Moser. 1992. Alterations of antioxidant tissue defense enzymes and related metabolic parameters in streptozotocin-diabetic rats-effects of iodine treatment. Wien Klin Wochensch 104 : 409-413
  21. Witztum, J.L., E.M. Mahoney. 1982. Branks MJ, Fisher M, Elam R, Steinberg D. Nonenzymatic glycosylation of low-density lipoprotein alters its biologic activity. Diabetes 31 : 283-291 https://doi.org/10.2337/diabetes.31.4.283
  22. Wolfe, S.P., R.T. Dean. 1987. Glucose Autoxidation and protein modification : The potential role 'autoxidative glycosylation' in diabetes mellitus. Biochem. J. 245 : 243-250 https://doi.org/10.1042/bj2450243
  23. Wolff, S.P. 1993. Diabetes mellitus and free radicals, transition metals and oxidative stress in the aetiology of diabetes mellitus and complication. Br. Med Bull 49: 642-652 https://doi.org/10.1093/oxfordjournals.bmb.a072637
  24. Wolever, T.M.S .. DJ.A. Jenkins, L.V. Thompson, G.S. Wong, R.G. Josse. 1986. Effect of canning the blood glucose response to beans in patients with type 2 diabetes. Hum Clin. Nutr. 41 : 135-140
  25. You, J.S., K.J. Chang. 1998. Effects of taurine supplimentation on lipid peroxidation, blood glucose and lipid metaboism in streptozotocin-induced rats. Adv. Exp. Med. Biol. 443 : 163-168
  26. Zacharia, M. 1983. Effect of brown rice and soybean dietary fiber on the control of glucose and lipid metabolism in diabetic rats. Am. J. clin. Nutr. 38 : 388-393