마황윤폐탕과 ciprofloxacin의 병용투여가 Streptococcus pneumoniae 호흡기감염에 대한 항균력에 미치는 영향

Investigation of in vivo Synergism of Mawhangyounpye-tang, a Poly-herbal Formula and Ciprof1oxacin against Streptococcus Pneumoniae Respiratory Infection

  • 안태호 (대구한의대 한의학과 폐계내과교실) ;
  • 송광규 (대구한의대 한의학과 폐계내과교실) ;
  • 전귀옥 (대구한의대 한의학과 폐계내과교실) ;
  • 서영호 (대구한의대 한의학과 폐계내과교실) ;
  • 조동희 (대구한의대 한의학과 폐계내과교실) ;
  • 박미연 (대구한의대 한의학과 폐계내과교실) ;
  • 최해윤 (대구한의대 한의학과 폐계내과교실) ;
  • 김종대 (대구한의대 한의학과 폐계내과교실)
  • An Tae-Ho (Division of Respiratory System, College of Oriental Medine, Daegu Haany University) ;
  • Song Kwang-Kyu (Division of Respiratory System, College of Oriental Medine, Daegu Haany University) ;
  • Jeon Kwi-Ok (Division of Respiratory System, College of Oriental Medine, Daegu Haany University) ;
  • Seo Young-Ho (Division of Respiratory System, College of Oriental Medine, Daegu Haany University) ;
  • Cho Dong-Hee (Division of Respiratory System, College of Oriental Medine, Daegu Haany University) ;
  • Park Mee-Yeon (Division of Respiratory System, College of Oriental Medine, Daegu Haany University) ;
  • Choi Hae-Yun (Division of Respiratory System, College of Oriental Medine, Daegu Haany University) ;
  • Kim Jong-Dae (Division of Respiratory System, College of Oriental Medine, Daegu Haany University)
  • 발행 : 2005.06.01

초록

Objectives & methods; In order to evaluate the in vivo synergic effect of Mawhangyounpye-tang, a traditional poly-herbal formula used in the treatment of respiratory diseases in Korea, with the quinolone antibiotic ciprofloxacin (CPFX), the viable bacterial number and histopathological changes were monitored after experimental respiratory infection with Streptococcus Pneumoniae ATCC 6303. Results: 1. In CPFX groups, the viable bacterial numbers were significantly decreased compared to that of the control group, and were even more dramatically decreased in concomitant group treated with Mawhangyounpye-tang. 2. In the control group, severe infiltration of inflammatory cells, hemorrhage and hypertrophy of alveolar linings were demonstrated at microscopic levels. However, these abnormal histopathological changes were significantly decreased compared. to that of the control group in CPFX groups, and were even more dramatically decreased in concomitant groups treated with Mawhangyounpye-tang. 3. In CPFX groups, the LSA (Iuminal surface of alveoli $\%$) were significantly increased compared to that of the control group, and more dramatically in concomitant groups treated with Mawhangyounpye-tang. Conclusions: According to these results, it is considered that the in vivo antibacterial activity of CPFX against Streptococcus Pneumoniae ATCC 6303 infection of respiratory tract was dramatically increased by concomitant use of Mawhangyounpye-tang.

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