Journal of the Korean Association of Oral and Maxillofacial Surgeons

The Korean Association of Oral and Maxillofacial Surgeons (대한구강악안면외과학회)
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A STUDY OF THE EFFECT OF CULTURED BONE MARROW STROMAL CELLS ON PERIPHERAL NERVE REGENERATION

체외 배양한 골수줄기세포를 이용한 말초신경재생에 관한 연구

  • Choi, Byung-Ho (Department of Oral & Maxillofacial Surgery, College of Dentistry, Yonsei University) ;
  • Zhu, Shi-Jiang (Department of Oral & Maxillofacial Surgery, College of Dentistry, Yonsei University) ;
  • Jung, Jae-Hyung ;
  • Huh, Jin-Young (Department of Dentistry, Gangneung Asan Hospital, University of Ulsan) ;
  • Lee, Seoung-Ho (Department of Periodontology, Ewha Womans University)
  • 최병호 (연세대학교 원주의과대학 치과학교실) ;
  • 주석강 (연세대학교 원주의과대학 치과학교실) ;
  • 정재형 (연세대학교 치과대학 구강악안면외과학교실) ;
  • 허진영 (울산대학교 의과대학 강릉아산병원 치과) ;
  • 이승호 (이화여자대학교 의과대학 치주과)
  • Published : 2005.12.31
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Abstract

The role of cultured bone marrow stromal cells (BMSCs) in peripheral nerve regeneration was examined using an established rabbit peroneal nerve regeneration model. A 15-mm peroneal nerve defect was bridged with a vein filled with BMSCs $(1{\times}10^6)$, which had been embedded in collagen gel. On the contralateral side, the defect was bridged with a vein filled with collagen gel alone. When the regenerated tissue was examined 4, 8 and 12 weeks after grafting, the number and diameter of the myelinated fibers in the side with the BMSCs were significantly higher than in the control side without the BMSCs. This demonstrates the potential of using cultured BMSCs in peripheral nerve regeneration.

Keywords

References

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