The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology (한방안이비인후피부과학회지)
- Volume 18 Issue 1
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- Pages.116-134
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- 2005
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- 1738-6640(pISSN)
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- 2234-4020(eISSN)
Effects of Sopoongsangagambang Administration along with External Spray Treatment on Atopic Dermatitis Development in NC/Nga Mice
소풍산가감방(消風散加減方)과 외치방(外治方) 병용이 NC/Nga 아토피 생쥐에 미치는 영향
Abstract
Although the parallel prescription of Sopoongsangagambang (SG) administration along with external treatment such as spraying or ointment application on the skin is clinically used for the treatment of atopic dermatitis (AD), molecular mechanism underlying its effectiveness is unknown. Thus in the present study, diverse immune responses in terms of chemical mediators related to AD were investigated using an atopic mouse model NC/Nga after SG administration and external treatment (ET), and major findings are summarized as follows. 1. The clinical severities in 16 and 20 week old NC/Nga mice with SG and ET treatment were decreased to 72.2% and 62.3% respectively compared to the control NC/Nga mice with no drug treatment. 2. IgE, IL-4, IL-5, IL-6, IL-13, IgM, IgG1 and IgG2a levels in the serum of SG and ET treated NC/Nga mouse group were significantly decreased compared to the untreated control mice. In contrast,