Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
권호 표지
DOI QR코드

DOI QR Code

Anti-rheumatoidal effects of Uncaria Tomentosa and Maytenus by a prolonged application

  • Choi, In-Sook (Graduate School of Health Science, Suzuka University of Medical Science) ;
  • Yamashita, Takenori (Graduate School of Health Science, Suzuka University of Medical Science) ;
  • Nakamura, Takashi (Graduate School of Health Science, Suzuka University of Medical Science) ;
  • Maenaka, Toshihiro (Hi-tech Research Center, Suzuka University of Medical Science) ;
  • Hasegawa, Takeo (Graduate School of Health Science, Suzuka University of Medical Science) ;
  • Itokawa, Yuka (Graduate School of Health Science, Suzuka University of Medical Science) ;
  • Ishida, Torao (Hi-tech Research Center, Suzuka University of Medical Science) ;
  • Rhee, Juong-Gile (Department of Radiation Oncology, BRB 6013, University of Maryland Baltimore) ;
  • Gu, Yeun-Hwa (Graduate School of Health Science, Suzuka University of Medical Science,Hi-tech Research Center, Suzuka University of Medical Science)
  • Published : 2005.12.30
Download PDF
⟨ Previous Next ⟩

Abstract

Uncaria Tomentosa and Maytenus are known to have anti-inflammatory and anti-rheumatoidal effects after either a single application or application over a short-term period. We applied these natural products to Wister rats every day for two weeks and investigated the effects of this long-term application on inflammation. This was done by measuring footpad edema, which was induced by a locally injected carrageenan. There was a dramatic reduction in edema in both U. Tomentosa- and Maytenus-treated rats; furthermore, the reduction lasted as long as three days for rats treated with U. Tomentosa. When the Balb/C mice underwent similar treatment for one month, the level of IgM in the blood of U. Tomentosa-treated mice decreased while the level of IgG in Maytenus-treated mice increased. This suggests that the long lasting effects of U. Tomentosa may be related to a low level of IgM and the subclass switch from IgM to IgG. Since the anti-inflammatory effects of U. Tomentosa lasts for three days, it may prove useful in treating rheumatoid arthritis when applied for an extended period of time, especially since this product is known to have minimal side effects.

Keywords

References

  1. Aquino R, De Simone F, Pizza C. (1988) New Quinovic Acid Glycosides from Uncaria Tomentosa. J. Nat. Prod. 51, 257-261. https://doi.org/10.1021/np50056a010
  2. Aquino R, De Simone F, Vincieri FF, Pizza C, Gacs-Baitz E. (1990) New polyhydroxylated triterpenes from Uncaria tomentosa. J. Nat. Prod. 53, 559-564. https://doi.org/10.1021/np50069a004
  3. Aquino R, De Feo V, De Simone F, Pizza C, Cirino G. (1991) Plant metabolites. New compounds and anti-inflammatory activity of Uncaria tomentosa. J. Nat. Prod. 54, 453-159. https://doi.org/10.1021/np50074a016
  4. Coffman RL, Carty J. (1986) A T cell activity that enhances polyclonal IgE production and its inhibition by interferon-gamma. J. Immunol. 136, 949-954.
  5. Dicarlo FJ, Haynes LJ, Sliver NJ, Phillips GE. (1964) Reticulo endothelial system stimulants of botanical orgin. J. Reticuloendothel. Soc. 64, 224-232.
  6. Feldmann M, Brennan FM, Maini RN. (1996) Role of cytokines in rheumatoid arthritis. Annu. Rev. Immunol. 14, 397-440. https://doi.org/10.1146/annurev.immunol.14.1.397
  7. Feldmann M, Brennan FM, Maini RN. (1996) Rheumatoid arthritis. Cell 85, 307-310. https://doi.org/10.1016/S0092-8674(00)81109-5
  8. Gonzalez JG, delle Monache G, delle Monache F, Marini-Bettolo GB. (1982) Chuchuhuasha - a drug used in folk medicine in the Amazonian and Andean areas. A chemical study of Maytenus laevis. J. Ethnopharmacol. 5, 73-77. https://doi.org/10.1016/0378-8741(82)90022-8
  9. Keffer J, Probert L, Cazlaris H, Georgopoulos S, Kaslaris E, Kioussis D, Kollias G. (1991) Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis. EMBO J. 10, 4025-4031.
  10. Kopf M, Le Gros G, Bachmann M, Lamers MC, Bluethmann H, Kohler G. (1993) Disruption of the murine IL-4 gene blocks Th2 cytokine responses. Nature 362, 245-248. https://doi.org/10.1038/362245a0
  11. Lanzavecchia A. (1985) Antigen-specific interaction between T and B cells. Nature 314, 537-539. https://doi.org/10.1038/314537a0
  12. Miossec P, van den Berg W. (1997) Th1/ Th2 cytokine balance in arthritis. Arthritis Rheum. 40, 2105-2015. https://doi.org/10.1002/art.1780401203
  13. Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL. (1986) Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136, 2348-2357.
  14. Noma Y, Sideras P, Naito T, Bergstedt-Lindquist S, Azuma C, Severinson E, Tanabe T, Kinashi T, Matsuda F, Yaoita Y, et al. (1986) Cloning of cDNA encoding the murine IgG1 induction factor by a novel strategy using SP6 promoter. Nature 319, 640-646. https://doi.org/10.1038/319640a0
  15. Recio MC, Giner RM, Manez S, Rios JL. (1995) Structural requirements for the anti-inflammatory activity of natural triterpenoids. Planta Med. 61, 182-185. https://doi.org/10.1055/s-2006-958045
  16. Senatore A, Cataldo A, Iaccarino FP, Elberti MG. (1989) Phytochemical and biological study of Uncaria tomentosa. Boll Soc. Ital. Biol. Sper. 65, 517-520.
  17. Stevens TL, Bossie A, Sanders VM, Femandez-Botran R, Coffman RL, Mosmann TR, Vitetta ES. (1988) Regulation of antibody isotype secretion by subsets of antigen-specific helper T cells. Nature 334, 255-258. https://doi.org/10.1038/334255a0
  18. Vitetta ES, Ohara J, Myers CD, Layton JE, Krammer PH, Paul WE. (1985) Serological, biochemical, and functional identity of B cell-stimulatory factor 1 and B cell differentiation factor for IgG1. J. Exp. Med. 162, 1726-1731. https://doi.org/10.1084/jem.162.5.1726
  19. Yamashita T, Gu YH. (2005) Anti-rheumatic, Anti-inflammatory and Analgetic Effects of Cat’s-claw Iporuru, Chuchuhuasi, and Devil's-claw Combination. Med. Bio. 149, 204-210.
  20. Yasukawa K, Takido M, Takeuchi M, Nakagawa S. (1989) Effect of chemical constituents from plants on 12-O-tetradecanoylphorbol-13-acetate-induced inflammation in mice. Chem. Pharm. Bull. 37, 1071-1073.
  21. Yepez AM, de Ugaz OL, Alvarez CM, De Feo V, Aquino R, De Simone F, Pizza C. (1991) Quinovic acid glycosides from Uncaria guianensis. Phytochemistry 30, 1635-1637. https://doi.org/10.1016/0031-9422(91)84223-F