Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
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Can herbal drug(s) meet the challenges of genomewide screen results on rheumatoid arthritis

  • Paul, Bholanath (Immunobiology Laboratory, Industrial Toxicology Research Centre)
  • Published : 2005.12.30
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Abstract

Rheumatoid arthritis (RA) is an autoimmune/inflammatory disorder with a complex genetic component. RA is characterized by chronic inflammation of the synovial membrane in the joint, which leads to the progressive destruction of articular cartilage, ligament and bone. Several cytokines such as tumor necrosis $factor-{\alpha}\;TNF-{\alpha}\;and\;interleukin-1{\beta}\;(IL-1{\beta})$ and interleukin-6 (IL-6) have been implicated in the pathological mechanisms of synovial tissue proliferation, joint destruction and programmed cell death in rheumatoid joint. Genome wide screening of subjects suffering from autoimmune diseases especially arthritis revealed linkage to inflammatory molecules like $TNF-{\alpha},\;IL-1{\beta}$ and IL-6, inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), nuclear factor-kappaB $(NF-{\kappa}B)$ and human leucocyte antigen/major histocompatibility complex (HLA/MHC) locus. The status of the pharmacological mechanism of herbal drugs in the light of genome wide screening results has been discussed to reinforce the therapeutic potential and the pharmacological basis of the herbal drugs.

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References

  1. Aho K, Koskenvuo M, Tuominen J, Kaprio J. (1986) Occurrence of rheumatoid arthritis in a nationwide series of twins. Arthritis Rheum. 13, 899-902.
  2. Shen CL, Hong KJ, Kim SW. (2003) Effects of ginger (Zingiber officinale Rosc.) on decreasing the production of inflammatory mediators in sow osteoarthrotic cartilage explants. J. Med. Food 323-328.
  3. Barak V, Birkenfeld S, Halperin T, Kalickman I. (2002) The effect of herbal remedies on the production of human inflammatory and anti-inflammatory cytokines. Isr. Med. Assoc. J. 4, 919-922.
  4. Barrera P, Faure S, Prud’homme JF, Balsa A, Migliorini P, Chimenti D, Radstake TR, van de Putte LB, Pascual-Salcedo D, Westhovens R, Maenaut K, Alves H, Lopes-Vaz A, Stravopoulos C, Spyropoulou M, Fritz P, Bardin T, Charron D, Lepage V, Alibert, Martinez M, Cornelis F. European Consortium on Rheumatoid Arthritis Families (ECRAF). European genetic study on rheumatoid arthritis: is there a linkage of the interleukin-1 (IL-1), IL-10 or IL-4 genes to RA? Clin. Exp. Rheumatol. 19, 709-714.
  5. Buchanan, W, Crooks J, Alexander D, Koutras D, Wayne E, Gray K. (1961) Lancet i, 245-248.
  6. Chen LF, Fischle W, Verdin E, Greene WC. (2001) Duration of Nuclear $NF-{\kappa}B$ action regulated by reversible acetylation. Science 293, 1653-1657. https://doi.org/10.1126/science.1062374
  7. Chiu JH, Ju CH, Wu LH, Lui WY, Wu CW, Shiao MS, Hong CY. (1998) Cordyceps sinensis increases the expression of major histocompatibility complex class II antigens on human hepatoma cell line HA22T/VGH cells. Am. J. Chin. Med. 26, 159-170. https://doi.org/10.1142/S0192415X9800021X
  8. Choi JS, Jung SW, Ju JC, Lee SW, Kim KY, Kim HM. (2002) Cytokine production regulation in human astrocytes by a herbal combination (Yuldahansotang). Immunopharm. Immunot. 24, 55-67. https://doi.org/10.1081/IPH-120003403
  9. Cornelis F, Faure S, Martinez M, Prud’homme JF, Fritz P, Dib C, Alves H, Barrera P, de Vries N, Balsa A, Pascual-Salcedo D, Maenaut K, Westhovens R, Migliorini P, Tran TH, Delaye A, Prince N, Lefevre C, Thomas G, Poirier M, Soubigou S, Alibert O, Lasbleiz S, Fouix S, Weissenbach J, et al. (1998) New susceptibility locus for rheumatoid arthritis suggested by a genome-wide linkage study. P. Natl. Acad. Sci. USA 95, 10746-10750. https://doi.org/10.1073/pnas.95.18.10746
  10. Deljunco D, Luthra H, Annegers J, Worthington J, Kurland L. (1984) The familial aggregation of rheumatoid arthritis and its relationship to the HLA-DR4 association. Am. J. Epidemiol. 119, 813-829.
  11. FeldmannM, Brennan F, Maini R. (1996) Rheumatoid arthritis. Cell 85, 307-310. https://doi.org/10.1016/S0092-8674(00)81109-5
  12. Frondoza CG, Sohrabi A, Polotsky A, Phan PV, Hungerford DS, Lindmark L. (2004) An in vitro screening assay for inhibitors of proinflammatory mediators in herbal extracts using human synoviocyte cultures. In Vitro Cell Dev. Biol. Anim. 40, 95-101. https://doi.org/10.1290/1543-706X(2004)040<0095:AIVSAF>2.0.CO;2
  13. Gao XX, Fei XF, Wang BX, Zhang J, Gong YJ, Minami M, Nagata T, Ikejima T. (2000) Effects of polysaccharides (FI0-b) from mycelium of Ganoderma tsugae on proinflammatory cytokine production by THP-1 cells and human PBMC (I). Acta Pharmacol. Sin. 21, 1179-1185.
  14. Gregersen P, Silver J, Winchester R. (1987) The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum. 30, 1205-1213. https://doi.org/10.1002/art.1780301102
  15. Harris E. (1989) In: Textbook of Rheumatology, edited by Kelley W, Harris E, Ruddy S, Sledge C. (Saunders, Philadelphia), pp. 943-974.
  16. Jang SI, Jeong SI, Kim KJ, Kim HJ, Yu HH, Park R, Kim HM, You YO. (2003) Tanshinone IIA from Salvia miltiorrhiza inhibits inducible nitric oxide synthase expression and production of TNF-alpha, IL-1beta and IL-6 in activated RAW 264.7 cells. Planta Med. 69, 1057-1059. https://doi.org/10.1055/s-2003-45157
  17. Jawaheer D, Seldin MF, Amos CI, Chen WV, Shigeta R, Monteiro J, Kern M, Criswell LA, Albani S, Nelson JL, Clegg DO, Pope R, Schroeder HW Jr, Bridges SL Jr, Pisetsky DS, Ward R, Kastner DL, Wilder RL, Pincus T, Callahan LF, Flemming D, Wener MH, Gregersen PK. (2001) A genomewide screen in multiplex rheumatoid arthritis families suggests genetic overlap with other autoimmune diseases. Am. J. Hum. Genet. 68, 927-936. https://doi.org/10.1086/319518
  18. Ju DW, Zheng QY, Cao X, Fang J, Wang HB. (1998) Esculentoside A inhibits tumor necrosis factor, interleukin-1, and interleukin-6 production induced by lipopolysaccharide in mice. Pharmacology 56, 187-195. https://doi.org/10.1159/000028197
  19. Kaneko M, Kawakita T, Yamaoka Y, Nomoto K. (2001) Development of the susceptibility to oral tolerance induction in infant mice administered a herbal drug. Hochu-ekki-to (Bu-Zhong-Yi-Qi-Tang). Int. Immunopharmacol. 1, 219-227. https://doi.org/10.1016/S1567-5769(00)00022-9
  20. Kim SW, Choi SC, Choi EY, Kim KS, Oh JM, Lee HJ, Oh HM, Kim S, Oh BS, Kim KC, Lee MH, Seo GS, Kim TH, Oh HC, Woo WH, Kim YS, Pae HO, Park DS, Chung HT, Jun CD. (2004) Catalposide, a compound isolated from Catalpa ovata, attenuates induction of intestinal epithelial proinflammatory gene expression and reduces the severity of trinitrobenzene sulfonic Acid-induced colitis in mice. Inflamm. Bowel Dis. 10, 564-572. https://doi.org/10.1097/00054725-200409000-00010
  21. Kumar IV, Paul BN, Asthana R, Saxena A, Mehrotra S, Rajan G. (2003) Swertia chirayita mediated modulation of interleukin-1beta, interleukin-6, interleukin-10, interferon-gamma, and tumor necrosis factor-alpha in arthritic mice. Immunopharm. Immunot. 25, 573-583. https://doi.org/10.1081/IPH-120026442
  22. Lawrence J. (1970) Paget’s disease in population samples. Ann. Rheum. Dis. 29, 357-379. https://doi.org/10.1136/ard.29.4.357
  23. Li X, Massa PE, Hanidu A, Peer GW, Arow P, Savitt A, Mische S, Li J, Marcu KB. (2002) $IKK{\alpha},\;IKK{\beta}$ and $NEMO/IKK{\gamma}$ are each required for the $NF{\kappa}B-mediated$ inflammatory response program. J. Biol. Chem. 277, 45129-45140. https://doi.org/10.1074/jbc.M205165200
  24. Lynn A, Kwoh C, Venglish C, Aston C, Chakravarti A. (1995) Genetic epidemiology of rheumatoid arthhritis. Am. J. Hum. Genet. 57, 150-159.
  25. Moser KL, Gaffney P, Peterson E, Behrens T. (2004) Keys to unlocking the mysteries of rheumatic autoimmune disease. Minn. Med. 87, 46-51.
  26. Ollier W. (1997) In: Genetics of Common Diseases, edited by Day I, Humphries S. (Bios, Oxford), pp. 171-183.
  27. Paul BN, Saxena AK, Ray PK. (1993) In vivo induction of tumor necrosis factor-a by soluble protein A from Staphylococcus aureus. Immunol. Infect. Dis. 3, 295-298.
  28. Paul BN, Saxena AK. (1997) Depletion of tumor necrosis factor-alpha in mice by Nyctanthes arbortristis. J. Ethnopharmacol. 56, 153-158. https://doi.org/10.1016/S0378-8741(97)01525-0
  29. Roitt I. (1993) Autoimmunity and Autoimmune Disease. In: Immunology edited by I Roitt, Brostoff J, Male D, 3rd Edition Mosby-Year Book Europe Ltd, London, p. 24.2-24.11.
  30. Male D. (1993) Cell migration and inflammation. In: Immunology edited by I Roitt, Brostoff J, Male D, 3rd Edition Mosby-Year Book Europe Ltd, London, p. 13.2-13.8.
  31. Schiffenbauer J, Schwartz BD. (1987) The HLA complex and its relationship to rheumatic diseases. Rheum. Dis. Clin. North Am. 13, 463-485.
  32. Shankaranarayan D, Gopalkrishnan C, Kameswaran L. (1979) Pharmacology of mangiferin. Indian J. Pharmaceutical Sci. 41, 78-82.
  33. Shin SS, Jin M, Jung HJ, Kim B, Jeon H, Choi JJ, Kim JM, Cho BW, Chung SH, Lee YW, Song YW, Kim S. (2003) Suppressive effects of PG201, an ethanol extract from herbs, on collagen-induced arthritis in mice. Rheumatology (Oxford). 42, 665-672.
  34. Shon YH, Lee HS, Kim CH, Lim JK, Jeon BH, Nam KS. (2004) Effect of herbal medicines on cytokine-induced cytotoxicity and major histocompatibility complex (MHC) class II antigen expression in rat thyroid cells. Biol. Pharm. Bull. 27, 371-374. https://doi.org/10.1248/bpb.27.371
  35. Silman A, MacGregor A, Thomson W, Holligan S, Carthy D, Farhan A, Ollier W. (1993) Twin concordance rates for rheumatoid arthritis: results from a nationwide study. Brit. J. Rheumatol. 32, 903-907. https://doi.org/10.1093/rheumatology/32.10.903
  36. Stastny P. (1978) Association of the B cells alloantigen DRw4 with rheumatoid arthritis. New Engl. J. Med. 28, 869-871.
  37. Thomas D, Young A, Gorsuch A, Bottazzo G, Cudworth A. (1983) Evidence for an association between rheumatoid arthritis and autoimmune endocrine disease. Ann. Rheum. Dis. 42, 297-300. https://doi.org/10.1136/ard.42.3.297
  38. Tsuchiya N, Tokunaga K. (1999) Analysis of susceptibility genes to rheumatic diseases. Nippon Rinsho. 57, 323-328.
  39. Wang B, Ma L, Tao X, Lipsky PE. (2004) Triptolide, an active component of the Chinese herbal remedy Tripterygium wilfordii Hook F, inhibits production of nitric oxide by decreasing inducible nitric oxide synthase gene transcription. Arthritis Rheum. 50, 2995-3003. https://doi.org/10.1002/art.20459
  40. Warton K, Foster NC, Gold WA, Stanley KK. (2004) A novel gene family induced by acute inflammation in endothelial cells. Gene 342, 85-95. https://doi.org/10.1016/j.gene.2004.07.027
  41. Wordsworth P, Bell J. (1992) Immunogenetics of rheumatoid arthritis. Springer Semin. Immunopathol. 14, 59-78.
  42. Wu MJ, Wang L, Ding HY, Weng CY, Yen JH. (2004) Glossogyne tenuifolia acts to inhibit inflammatory mediator production in a macrophage cell line by downregulating LPS-induced NF-kappa B. J. Biomed. Sci. 11, 186-199.
  43. Yeom MJ, Lee HC, Kim GH, Shim I, Lee HJ, Hahm DH. (2003) Therapeutic effects of Hominis placenta injection into an acupuncture point on the inflammatory responses in subchondral bone region of adjuvant-induced polyarthritic rat. Biol. Pharm. Bull. 26, 1472-1477. https://doi.org/10.1248/bpb.26.1472
  44. Zhang L, Huang Y, Qian Y, Xiao P. (1995) Effect of deoxynupharidine on immune function in vitro. Zhongguo Yi Xue Ke Xue Yuan Xue Bao 17, 343-348.