Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
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Antifilarial activity of Nigella sativa on Setaria cervi-an in vitro study

  • Rizvi, Waseem (Department of Pharmacology, J.N. Medical College, Aligarh Muslim University) ;
  • Kumar, Anil (Department of Pharmacology, J.N. Medical College, Aligarh Muslim University) ;
  • Rizvi, NH (Department of Pharmacology, J.N. Medical College, Aligarh Muslim University) ;
  • Ahmad, Razi (Department of Pharmacology, J.N. Medical College, Aligarh Muslim University) ;
  • Singhal, KC (Department of Pharmacology, J.N. Medical College, Aligarh Muslim University) ;
  • Khan, Atif (Department of Pharmacology, J.N. Medical College, Aligarh Muslim University)
  • Published : 2005.09.30
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Abstract

The effect of aqueous and alcoholic extract of seeds of Nigella sativa (N. sativa) was studied on the spontaneous movements of the whole worm (w.w) preparation and nerve muscle (n.m) complex of Setaria cervi (S. cervi). Both the extracts caused inhibition of spontaneous movements of the w.w and n.m complex characterized by initial stimulation followed by irreversible paralysis, with the exception that aqueous extract produced a partially reversible paralysis of w.w preparation. Lesser concentration of both the extracts was required to inhibit the movements of n.m complex than the w.w. Suggesting a cuticular permeability barrier. The lethal concentration $50\;(LC_{50})$ and lethal concentration $90\;(LC_{90})$ were 30 and 55 ng/ml for aqueous and 45 and 60 ng/ml for alcoholic extracts respectively.

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