Advances in Traditional Medicine

  • 제5권3호
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  • Pages.231-235
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  • 2005
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  • 2662-4052(pISSN)
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  • 2662-4060(eISSN)
경희대학교 융합한의과학연구소 (Kyung Hee Oriental Medicine Research Center)
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Effects of Callophyllis japonica powder on carbon tetrachloride-induced liver injury in rats

  • Park, Dal-Soo (Department of Veterinary Medicine, Graduate School, Cheju National University) ;
  • Lee, Ki-Hyun (Department of Veterinary Medicine, Graduate School, Cheju National University) ;
  • Kim, Hee-Chul (Department of Veterinary Medicine, Graduate School, Cheju National University) ;
  • Ahn, Mee-Jung (Department of Veterinary Medicine, Graduate School, Cheju National University) ;
  • Moon, Chang-Jong (Department of Veterinary Medicine, Graduate School, Cheju National University) ;
  • Ko, Myung-Soon (Department of Veterinary Medicine, Graduate School, Cheju National University) ;
  • Lee, Kyoung-Kap (Department of Veterinary Medicine, Graduate School, Cheju National University) ;
  • Go, Gyung-Min (Provincial Fisheries Resources Research Institute) ;
  • Shin, Tae-Kyun (Department of Veterinary Medicine, Graduate School, Cheju National University)
  • 발행 : 2005.09.30
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초록

A limited number of studies have been conducted on the bioactivity of Callophyllis japonica (C. japonica), which is a red seaweed that is traditional in the oriental diet. In this report, the hepatoprotective effect of C. japonica was studied in a carbon tetrachloride $(CCl_4)-induced$ hepatotoxicity model in rats. A single intraperitoneal injection of 1.25 ml/kg of 20% $CCl_4$ in olive oil produced an elevated level of serum glutamic pyruvic transaminase (SGPT) and increased enzyme activity of serum glutamic oxaloacetic transaminase (SGOT). Pre-treatment with C. japonica (150 mg/kg/d) for 3 days in $CCl_4-injected$ rats reduced the levels of SGPT and SGOT compared with control levels (P < 0.05), while higher doses (300 and 600 mg/kg) were ineffective. The administration of C. japonica (150 mg/kg/d) for 3 days after the $CCl_4$ injection in rats was ineffective at reducing SGPT and SGOT. The histopathological findings in each group largely agreed with the biochemical data. The results of this study support the suggestion that C. japonica has a hepatoprotective effect on chemical-induced liver injury.

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참고문헌

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피인용 문헌

  1. The radioprotective effects of the hexane and ethyl acetate extracts of Callophyllis japonica in mice that undergo whole body irradiation vol.9, pp.3, 2008, https://doi.org/10.4142/jvs.2008.9.3.281
  2. Anti-inflammatory effect of polyphenol-rich extract from the red alga Callophyllis japonica in lipopolysaccharide-induced RAW 264.7 macrophages vol.29, pp.4, 2014, https://doi.org/10.4490/algae.2014.29.4.343