Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
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Inhibitory effect of Anglicae dahuricae radix on mast cell mediated inflammatory responses

  • Park, Jong-Ha (College of Oriental Medicine, Wonkwang University) ;
  • Choi, In-Young (College of Pharmacy, Wonkwang University,College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University) ;
  • Na, Ho-Jeong (College of Pharmacy, Wonkwang University,College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University) ;
  • Jeong, Hyun-Ja (College of Pharmacy, Wonkwang University,College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University) ;
  • Ko, Seong-Guem (College of Pharmacy, Wonkwang University) ;
  • Lee, Byung-Hee (College of Pharmacy, Wonkwang University) ;
  • Song, Yong-Sun (College of Oriental Medicine, Wonkwang University) ;
  • Kim, Hyung-Min (College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University) ;
  • Hong, Seung-Heon (College of Pharmacy, Wonkwang University) ;
  • Um, Jae-Young (College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University)
  • Published : 2005.09.30
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Abstract

The Angelicae dahuricae radix (ADR) has been used a traditional medicine to treat acne, erythema, headache, toothache, sinusitis, colds, and flu in Korea, Japan and China. Here, we report the effect of ADR on compound 48/80-induced ear-swelling and the phorbol myristate acetate (PMA) plus calcium ionophore A23187-induced inflammatory cytokine secretion in the human mast cell line, HMC-1. ADR dose-dependently inhibited the ear-swelling response induced by intradermal injection of compound 48/80, In vitro model, PMA plus A23187 significantly increased interleukin $(IL)-1{\beta}$, IL-8, granulocyte macrophage colony stimulating factor (GM-CSF), and tumor necrosis factor $(TNF)-{\alpha}$ secretion compared with media control. We also show that the increased cytokines $IL-1{\beta}$, IL-8, GM-CSF, and $TNF-{\alpha}$ level was significantly inhibited by treatment of ADR. In addition, ADR partially blocked PMA plus A23187-induced extracelluar signal-regulated kinases phosphorylation. These results suggest that ADR might explain its beneficial effect in the treatment of mast cell-mediated inflammatory diseases.

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References

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