Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
권호 표지
DOI QR코드

DOI QR Code

Antioxidant and immuno-enhancing effects of Echinacea purpurea (American herb) in vivo

  • Gu, Yeun-Hwa (Graduate School of Health Science. Suzuka University of Medical Science) ;
  • Maenaka, Toshihiro (Graduate School of Health Science. Suzuka University of Medical Science) ;
  • Saito, Kiyoto (Graduate School of Health Science. Suzuka University of Medical Science) ;
  • Yamashita, Takenori (Graduate School of Health Science. Suzuka University of Medical Science) ;
  • Choi, In-Suk (Graduate School of Health Science. Suzuka University of Medical Science) ;
  • Terai, Kaoru (Graduate School of Health Science. Suzuka University of Medical Science) ;
  • Ahn, Kyoo-Seok (Department of Pathology, College of Oriental medicine, Institute of Oriental Medicine, Kyunghee University)
  • Published : 2005.03.30
Download PDF
⟨ Previous Next ⟩

Abstract

We studied the protective effect of Echinacea purpurea against radiation by evaluating changes in the peripheral blood cell count and peripheral blood antioxidant activity. Echinacea purpurea administration had a suppressive effect on radiation-induced leukopenia, especially on lymphocytes and monocytes and resulted in a faster recovery of blood cell counts. Mouse peripheral blood antioxidant activity was increased by Echinacea purpurea, and a relationship between the suppressive effect on radiation-induced leukopenia and the antioxidant effect was suggested.

Keywords

References

  1. Agner H, Proksch A, Riess-Maurer I. (1985) Immunostimulating action of polysaccharides (heteroglycans) from higher plants. Arzneim. Forsch. 35,1069-1075.
  2. Andreassen CN, Grau C, Lindegaard JC, (2003) Chemical radioprotection: a critical review of amifostine as a cytoprotector in radiotherapy. Semin. Radiat. Oncol. 13,62-72. https://doi.org/10.1053/srao.2003.50006
  3. Bauer R. (2002) New knowledge regarding the effect and effectiveness of Echinacea purpurea extracts. Wien Med. Wochenschr. 152,407-411. https://doi.org/10.1046/j.1563-258X.2002.02063.x
  4. Bauer R, Jurcic K, Puhlmann J, Wagner H (1988) Immunologic in vivo and in vitro studies on Echinacea extracts. Arzneim-Forsch. 38, 276-281.
  5. Bauer R, Remiger P, WagnerH (1989) Alkamides from the Roots of Echinaceaangusti-folia.Phytochemistry 28,505-508. https://doi.org/10.1016/0031-9422(89)80042-1
  6. Becker H, Hsieh W, Wylde R, Laffite C, Andary C (1982) Structure of Echinacoside. Z. Naturforsch 37, 351-353.
  7. Beuscher N, Bodinet C, Willigmann I, Egert D. (1995) Immunmodu1ierende Eigenschaften von Wurzelextrakten verschiedener Echinacea-Arten. Z. Phytotherapie 16, 157-166.
  8. Brown DJ. (1986) Effect of Atropa belladonna and Echinacea angustifolia in homeopathic dilution on experimental peritonitis. Therapiewoche 36, 3352-3358.
  9. Bukovsky M, Vaverkova S, Kostalova D, Magnusova R. (1993) Immunomodulating activity of ethanolwater extracts of the roots of Echinacea gloriosa L., Echinacea angustifolia DC and Rudbeckia speciosa Wenderoth tested on the immune system in C57BL6 inbred mice. Cesk. Farm. 42, 184-187.
  10. Freeman BA, Crapo JD. (1982)Biology of disease: Free radicals and tissue injury. Lab. Invest. 47, 412-426.
  11. Georgieva R, Tsevi R, Kossev K, Kusheva R, Balgjiska M, Petrova R, Tenchova V, Gitsov I, Troev K. (2002) Immobilization of aminothiols on poly(oxyalkylene phosphates).Formationof poly(oxyethylene phosphates)/ cysteamine complexes and their radioprotective efficiency. Int. J. Med. Chem. 45, 5797-5801. https://doi.org/10.1021/jm020309o
  12. Goel V, Chang C, Slama Iv, Barton R, Bauer R, Gahler R, Basu TK. (2002a) Alkylamides of Echinacea purpurea stimulate alveolar macrophage function in normal rats. Immunopharmacol. 2, 381-387. https://doi.org/10.1016/S1567-5769(01)00163-1
  13. Goel V, Chang C, Slama J, Barton R, Bauer R, Gahler R, Basu T. (2002b) Echinacea stimulates macrophage function in the lung and spleen of normal rats. J. Nutr. Biochem. 13, 487. https://doi.org/10.1016/S0955-2863(02)00190-0
  14. Hall EJ. (2000) Radiobiology for the Radiologist, pp. 339-366, Wolters Kluwer Co.
  15. Hu C, Kitts DD. (2000) Studies on the antioxidant activity of Echinacea root extractA@ Studies on the antioxidant activity of Echinacea root extract. J. Agric. Food Chem. 48, 1466-1472. https://doi.org/10.1021/jf990677+
  16. Isla MI, Nieva Moreno MI, Sampietro AR, Vattuone MA (2001) Antioxidant activity of Argentine propolis extracts. J. Ethnopharmacol. 76, 165-170. https://doi.org/10.1016/S0378-8741(01)00231-8
  17. Jacobson M. (1967) The structure of echinacein, the insecticidal component of American coneflower roots. J. Org. Chem. 32, 1646-1647. https://doi.org/10.1021/jo01280a091
  18. Jorgensen C, Brocks V, Bang J, Jorgensen FS, Ronsbro L. (2003) Treatment of severe fetal chylothorax associated with pronounced hydrops with intrapleural injection of OK-432. Ultrasound Obstet. Gynecol. 21, 66-69. https://doi.org/10.1002/uog.23
  19. Kwarek T, Tynecka Z, Glowniak K, Lutostanska E. Echinacea L. (1996) Inducer of interferons. Herba Polonica 17, 110-117.
  20. Luettig B,SteinmullerC (1989) Macrophage activation by the polysaccharide arabinogalactan isolated from plant cell cultures of Echinacea purpurea. J. Natl. Cancer Inst. 81, 669-675. https://doi.org/10.1093/jnci/81.9.669
  21. Moerman DE. (1998) Native American Ethnobotany, Timber Press, Portland.
  22. Rininger JA, Kickner S, Chigurupati P, McLean A, Franck Z. (2000) Immunopharmacological activity of Echinaceapreparations following simulated digestion on murine macrophages and human peripheral blood mononuclear cells. J. Leukoc. BioI. 68, 503-510.
  23. See DM, Broumand N, Sahl L, Tilles JG. (1997)In vitro effects of echinacea and ginseng on natural killer and antibody-dependent cell cytotoxicity in healthy subjects and chronic fatigue syndrome or acquired inununodeficierey syndrome patients. Immunopharmacology 35, 229-235. https://doi.org/10.1016/S0162-3109(96)00125-7
  24. Sloley BD, Urichuk LJ, Tywin C, Coutts RT, Pang PK, Shan JJ. (2001) Comparison of chemical components and antioxidants capacity of different Echinacea species. J. Pharm. Pharmacol. 53, 849-857. https://doi.org/10.1211/0022357011776009
  25. XiongQ Kadota S, Tani T,Namba T.(1996) Antioxidative effects of phenylethanoids from Cistanche deserticola. Biol. Pharm. Bull. 19, 1580-1585. https://doi.org/10.1248/bpb.19.1580
  26. Yang K, Azoulay E, Attalah L, Zahar JR, Van De Louw A, Cerf C, Soussy0, Duvaldestin P, Brochard L, Brun-Buisson C, Harf A, Delclaux C. (2003) Bactericidal activity response of blood neutrophils from critically ill patients to in vitro granulocyte colony-stimulating factor stimulation. Intensive Care. Med. 29, 396-402. https://doi.org/10.1007/s00134-002-1623-9
  27. Wagner H, Proksch A, Riess-Maurer I, Vollmar A, Odenthal S, Stuppner H, [urcic K, Le Turdu M, Fang IN. (1991) The effect of Echinacea angustifolia on non-specific cellular immunity in the mouse. Arzneimittelforschung 41,141-147.