Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
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The anti-hyperglycemic property of different ginseng partitions

  • Xie, Jing-Tian (Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, The University of Chicago,Department of Anesthesia & Critical Care, The Pritzker School of Medicine, The University of Chicago) ;
  • Wang, Chong-Zhi (Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, The University of Chicago,Department of Anesthesia & Critical Care, The Pritzker School of Medicine, The University of Chicago) ;
  • Kim, Stephen (Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, The University of Chicago,Department of Anesthesia & Critical Care, The Pritzker School of Medicine, The University of Chicago) ;
  • Yuan, Chun-Su (Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, The University of Chicago,Department of Anesthesia & Critical Care, The Pritzker School of Medicine, The University of Chicago,Committee on Clinical Pharmacology and Pharmacogenomics, The Pritzker School of Medicine, The University of Chicago)
  • Published : 2005.03.30
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Abstract

Ginseng is a popular medicinal plant highly valued throughout the world. Asian ginseng is one of the most common species of ginseng. It has long occupied a significant position in oriental medicine and has been justified its name as the 'king herb'. As a nutritional supplement, ginseng is an extremely common and popular herbal medicine in the United States and Canada in recent decades. The multiple constituents of ginseng possess equally multifaceted pharmacological actions as demonstrated by numerous studies. Ginseng root and its constituents influenced the central nervous system, endocrine, cardiovascular, gastrointestinal system, sexual, renal organ and immune system, etc. One important action is its anti-hyperglycemic effect. Previous studies on ginseng demonstrate that only the root of ginseng has been used in the treatment of diabetes, while the other parts of ginseng plant were always neglected. Recently, we analyzed the constituents of ginseng berry, leaf and discovered that ginseng berry, leaf extracts and its total ginsenosides have the ability to reduce hyperglycemia and body weight and increase the peripheral glucose utilization in obese or diabetic ob/ob or db/db mice. Our data suggest that all parts of ginseng plant, including root, berry, leaf and stem exhibit potent anti-hyperglycemic and anti-obese effects and may provide an opportunity to develop a novel class of anti-diabetic agents.

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