Journal of Pharmaceutical Investigation

  • 제35권6호
  • /
  • Pages.403-409
  • /
  • 2005
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  • 2093-5552(pISSN)
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  • 2093-6214(eISSN)
한국약제학회 (The Korean Society of Pharmaceutical Sciences and Technology)
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마이크로 피부침을 이용한 FITC-OVA의 경피흡수

Transdermal Delivery of FITC-Ovalbumin with Microneedle System

  • 장우영 (전북대학교 고분자 나노공학과) ;
  • 이창래 (전북대학교 고분자 나노공학과) ;
  • 서성미 (부경대학교 고분자공학과) ;
  • 이봉 (부경대학교 고분자공학과) ;
  • 김문석 (한국화학연구원 생체의료고분자팀) ;
  • 강길선 (전북대학교 고분자 나노공학과, 한국화학연구원 생체의료고분자팀) ;
  • 이한구 (디에스엔지) ;
  • 이해방 (전북대학교 고분자 나노공학과, 한국화학연구원 생체의료고분자팀)
  • Jang, Woo-Young (Department of Polymer Nano Science and Technology, Chonbuk National University) ;
  • Lee, Chang-Rae (Department of Polymer Nano Science and Technology, Chonbuk National University) ;
  • Seo, Seong-Mi (Department of Polymer Engineering, Pukyong National University) ;
  • Lee, Bong (Department of Polymer Engineering, Pukyong National University) ;
  • Kim, Moon-Suk (Nanobiomaterials Laboratory, Korea Research Institute of Chemical Technology) ;
  • Khang, Gil-Son (Department of Polymer Nono Science and Technology, Chonbuk National University, Nanobiomaterials Laboratory, Korea Research Institute of Chemical Technology) ;
  • Lee, Han-Gu (DS&G Co. Ltd.) ;
  • Lee, Hai-Bang (Department of Polymer Nono Science and Technology, Chonbuk National University, Nanobiomaterials Laboratory, Korea Research Institute of Chemical Technology)
  • 발행 : 2005.12.20
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초록

For transdermal delivery of large molecular drugs such as vaccine and protein drugs, novel microneedle treatment device with roll was designed. The roll dimension is 1.43 cm diameter and 2.8 cm perimeter. Total number of microneedle on the roll is 3,360 with $230\;{\mu}m$ height and $740\;{\mu}m$ distance. The pore with $150\;{\mu}m$ depth and $35\;{\mu}m$ diameter on the skin was made by the designed microneedle device. This system could be achieved without pain. The permeation rates of FITC labelled ovalbumin (FITC-OVA, molecular weight: 45,000 g/mol) as a model protein were determined by modified Franz diffusion cells using skins of hairless mice or SD rats which were treated by using microneedle device two or four times. The average penetration fluxes of model protein increased from 674 to $872\;{\mu}g/cm^{2}{\cdot}hr$ as the number of treatment to make pore increased from two to four times. In conclusion, we confirmed the possibility of using the designed microneedle treatment device for transdermal delivery of the large molecular drugs.

키워드

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