Natural Product Sciences

  • 제11권4호
  • /
  • Pages.199-206
  • /
  • 2005
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  • 1226-3907(pISSN)
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  • 2288-9027(eISSN)
한국생약학회 (The Korean Society of Pharmacognosy)
권호 표지

Phytochemical and Pharmacological Investigations on Moringa peregrina (Forssk) Fiori

  • Elbatran, Seham A. (Departments of Pharmacology, Chemistry of Medicinal Plants, National Research Centre) ;
  • Abdel-Salam, Omar M. (Departments of Pharmacology, Chemistry of Medicinal Plants, National Research Centre) ;
  • Abdelshfeek, Khaled A. (Chemistry of Medicinal Plants, National Research Centre,Chemistry Department, Faculty of Science, Al-Tahady University) ;
  • Nazif, Naglaa M. (Chemistry of Medicinal Plants, National Research Centre) ;
  • Ismail, Shams I. (Chemistry of Medicinal Plants, National Research Centre) ;
  • Hammouda, Faiza M. (Chemistry of Medicinal Plants, National Research Centre)
  • 발행 : 2005.12.01
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초록

Investigation of M. peregrina aerial parts revealed the isolation and identification of 4-flavonoidal compounds, quercetin, quercetin-3-0-rutinoside (rutin), chrysoeriol-7-0-rhamnoside 6,8,3',5'-tetramethoxy apigenin. The compounds were identified by TLC, PC, MS, and $H^1-NMR$. The fatty acids and unsaponifiable matter were studied. The $LD_{50}$ for M. peregrina was 113.4 mg/100g b.wt. Repeated intraperitoneal injection of 1/20 and 1/10 $LD_{50}$ (5.67 mg and 11.34 mg/100g b.wt.) of defatted alcoholic of M. peregrina for 30 days induced significant decrease in serum glucose, liver enzymes and lipid components. M. peregrina administered i.p., 30min prior to carrageenan at the above doses significantly inhibited the rat paw oedema response, In acute pain models, namely, the acetic acid-induced writing and hot-plate assay, M. peregrina exhibited marked analgesic properties. In addition, M. peregrina administered at time of indomethacin injection inhibited the development of gastric lesions in rats.

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