대한한의학방제학회지 (Herbal Formula Science)
- 제13권1호
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- Pages.49-69
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- 2005
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- 1229-1218(pISSN)
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- 2288-5641(eISSN)
순기활혈탕(順氣活血湯)의 뇌허혈(腦虛血) 억제효과(抑制效果)에 관한 실험적(實驗的) 연구(硏究)
The Experimental Study of Sunkihwalhyul-Tang against Inhibitive Effects on the Brain Ischemia
- 홍석 (동신대학교 한의과대학 내과학교실) ;
- 안정조 (동신대학교 한의과대학 내과학교실) ;
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전상윤
(동신대학교 한의과대학 내과학교실) ;
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최창원
(동신대학교 한의과대학 내과학교실) ;
- 정영득 (동신대학교 한의과대학 내과학교실)
- Hong, Seok (Department of Internal Medicine, College of Oriental Medicine, Dongshin University) ;
- Ann, Jeong-Jo (Department of Internal Medicine, College of Oriental Medicine, Dongshin University) ;
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Jeong, Sang-Yoon
(Department of Internal Medicine, College of Oriental Medicine, Dongshin University) ;
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Choi, Chang-Won
(Department of Internal Medicine, College of Oriental Medicine, Dongshin University) ;
- Jeong, Young-Deuk (Department of Internal Medicine, College of Oriental Medicine, Dongshin University)
- 발행 : 2005.06.30
초록
This Study was designed to investigate the effect of Sunkihwalhyul -Tang extract(SHT) on the change of cerebral hemodynamics [regional cerebral blood flow(rCBF), pial arterial diameter(PAD) and mean arterial blood pressure(MABP)] in normal and cerebral ischemic rats, and further to determine the mechanisms of action of SHT on hemodynamics. In addition, this study was designed to investigate whether SHT inhibits lactate dehydrog enase(LDH) activity in neuronal cells and cytokines production in serum of cerebral ischemic rats. The results were as follows 1. SHT significantly increased rCBF and PAD in a dose-dependent manner, but MABP was not changed by injecting SHT. These results suggest that SHT significantly increases rCBF by dilating PAD. 2. The SHT-induced increase in rCBF was significantly inhibited by pretreatment with indomethacin(IDN, 1 mg/kg, i.p.), an inhibitor of cyclooxygenase and methylene blue(MTB,