대한한의학방제학회지 (Herbal Formula Science)

  • 제13권1호
  • /
  • Pages.1-7
  • /
  • 2005
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  • 1229-1218(pISSN)
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  • 2288-5641(eISSN)
대한한의학방제학회 (The Korean Medicine Society for the Herbal Formula Study)
권호 표지

동결 건조법을 이용한 옥천산 캡슐 제형 개발에 관한 연구

A Study of Okchun-San Formulation for Freeze Drying Capsulation

  • 오명숙 (경희대학교 한의과대학 방제학교실) ;
  • 김도림 (경희대학교 한의과대학 방제학교실) ;
  • 강지웅 (경희대학교 한의과대학 방제학교실) ;
  • 장문석 (하버드대학교 의과대학 소아병원) ;
  • 박선민 (호서대학교 자연과학대학) ;
  • 고병섭 (한국한의학연구원) ;
  • 박성규 (경희대학교 한의과대학 방제학교실)
  • Oh, Myung-Sook (Dept. of Prescriptionology, College of Oriental Medicine, Kyung Hee University) ;
  • Kim, Do-Rim (Dept. of Prescriptionology, College of Oriental Medicine, Kyung Hee University) ;
  • Kang, Ji-Ung (Dept. of Prescriptionology, College of Oriental Medicine, Kyung Hee University) ;
  • Chang, Mun-Seog (Dept. of Medicine, Division of Newborn Medicine, Children's Hospital and Harvard Medical School) ;
  • Park, Sun-Min (Food and Nutrition, Hoseo University) ;
  • Ko, Byoung-Seob (Korea Institute of Oriental Medicine) ;
  • Park, Seong-Kyu (Dept. of Prescriptionology, College of Oriental Medicine, Kyung Hee University)
  • 발행 : 2005.06.30
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초록

Objective : Okchun-San(OCS) is known as an effective herbal medicine on Type 2 diabetes. We performed to change OCS formulation for freeze drying capsulation. Methods The mixtures of OCS were extracted with water. finally, the filtered solution were evaporated and lyophilized to dry granules. The various ratio of excipients were studied to determine the formation for capsulizing. The samples were inspected for any difference in color, taste and appearance. Results: The prepared form of OCS were dried and weighted 260kg. The lyophilized dry powder yielding 40kg. The suitable ratio of OCS-dry powder and excipient was 10:1. The average weights of On and placebo capsules were $440{\pm}5.28mg$, $465{\pm}7.95mg$, respectively. There was no notable change in color and appearance for both capsuled samples throughout the study period. Conclusions: Therefore in can be concluded that freeze drying capsulation is appropriate form of OCS.

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