대한한방피부미용학회지 (Korean Journal of Korean Medical Institute of Dermatology and Aesthetics)
- 제1권1호
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- Pages.5-15
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- 2005
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- 1738-6500(pISSN)
황기 물추출물이 B16F10 Mouse Melanoma세포의 멜라닌 생성에 미치는 영향
Effect of the Aqueous Extract of Astragalus membranaceous BUNGE on Melanin Formation in B16 Mouse Melanoma Cell Line
- Kim, Young-Ock (Jaseng Research Institute of Biotechnology and Bioscience) ;
- Lee, Eun-Mi (Dr. Lady's Oriental Clinic) ;
- Ahn, Duk-Kyun (Jaseng Research Institute of Biotechnology and Bioscience) ;
- Shin, Jun-Sik (Jaseng Research Institute of Biotechnology and Bioscience) ;
- Lee, Sung-Whan (Jaseng Research Institute of Biotechnology and Bioscience)
- 발행 : 2005.04.10
초록
The purpose of this study was to investigate the effect of the aqueous extract of the Astragalus membranaceous(AM). AM showed inhibitory effect on the tyrosinase activity using L-tyrosine as a substrate. Tyrosinase plays an important role in the process of melanin polymer biosynthesis. In vitro AM extract(1mg/ml) inhibited melanin biosynthesis and are useful for the material used in cosmetics. B16 mouse melanoma cells were cultured in different concentrations. The non-cytotoxicity of the plant extracts was confirmed by MTT assay.
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