Korean Journal of Korean Medical Institute of Dermatology and Aesthetics (대한한방피부미용학회지)

Korean Medical Institute of Dermatology and Aesthetics (대한한방피부미용학회)
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Effect of the Aqueous Extract of Astragalus membranaceous BUNGE on Melanin Formation in B16 Mouse Melanoma Cell Line

황기 물추출물이 B16F10 Mouse Melanoma세포의 멜라닌 생성에 미치는 영향

  • Kim, Young-Ock (Jaseng Research Institute of Biotechnology and Bioscience) ;
  • Lee, Eun-Mi (Dr. Lady's Oriental Clinic) ;
  • Ahn, Duk-Kyun (Jaseng Research Institute of Biotechnology and Bioscience) ;
  • Shin, Jun-Sik (Jaseng Research Institute of Biotechnology and Bioscience) ;
  • Lee, Sung-Whan (Jaseng Research Institute of Biotechnology and Bioscience)
  • Published : 2005.04.10
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Abstract

The purpose of this study was to investigate the effect of the aqueous extract of the Astragalus membranaceous(AM). AM showed inhibitory effect on the tyrosinase activity using L-tyrosine as a substrate. Tyrosinase plays an important role in the process of melanin polymer biosynthesis. In vitro AM extract(1mg/ml) inhibited melanin biosynthesis and are useful for the material used in cosmetics. B16 mouse melanoma cells were cultured in different concentrations. The non-cytotoxicity of the plant extracts was confirmed by MTT assay.

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