Korean Journal of Korean Medical Institute of Dermatology and Aesthetics (대한한방피부미용학회지)
- Volume 1 Issue 1
- /
- Pages.91-97
- /
- 2005
- /
- 1738-6500(pISSN)
Inhibitory Activity of Medicinal Plant Extracts against Tyrosinase
약용식물 추출물의 Tyrosinase 억제 활성
- Na, Min-Kyun (Korea Research Institute of Bioscience and Biotechnology (KRIBB)) ;
- Choi, Seung-Youl (Jakwang Research Institute, Han Kook Sin Yak Co., Ltd) ;
- Kim, Dong-Hee (Jakwang Research Institute, Han Kook Sin Yak Co., Ltd) ;
- Kim, Jin-Pyo (Jakwang Research Institute, Han Kook Sin Yak Co., Ltd) ;
- Lee, Chan-Bok (Jakwang Research Institute, Han Kook Sin Yak Co., Ltd) ;
- Kim, Kyung-Dong (Hansaeng Natiural Cosmetics Co., Ltd)
- 나민균 (한국생명공학연구원) ;
- 최승열 ((주)한국신약 자광연구소) ;
- 김동희 ((주)한국신약 자광연구소) ;
- 김진표 ((주)한국신약 자광연구소) ;
- 이찬복 ((주)한국신약 자광연구소) ;
- 김경동 ((주)한생화장품)
- Published : 2005.04.10
Abstract
(1) Objectives: To discover natural skin-lightening agents, we have evaluated the inhibitory activity of EtOH extracts from 20 medicinal plants against mushroom tyrosinase. (2) Methods: Tyrosinase activity was determined by the dopachrome method using L-tyrosine as the substrates. (3) Results: Of the plant extracts tested, the extracts of 4 plants, Albizzia julibrissin, Curcuma longa, Anethum graveolens and Sophora flavescens, exhibited potent inhibitory activity (> 50%) in mushroom tyrosinase assay. Four plant extract, extracts of Agrimonia pilosa, Paeonia moutan, Magnolia obovata and Eugenia caryophyllata also showed relatively strong inhibitory (> 40%) against mushroom tyrosinase. (4) Conclusion: These active medicinal plants may be useful for the development of skin-whitening agents. Since the active medicinal plants may contain effective tyrosinase inhibitors even more than kojic acid, further study to identify the active constituents from the plants is expected.
Keywords