동의신경정신과학회지 (Journal of Oriental Neuropsychiatry)

  • 제16권1호
  • /
  • Pages.119-128
  • /
  • 2005
  • /
  • 1226-6396(pISSN)
  • /
  • 2234-4942(eISSN)
대한한방신경정신과학회 (The Korean Society of Oriental Neuropsychiatry)
권호 표지

백서의 기억능력에 대한 조구등(釣鉤藤) 디클로로메탄분획의 효과

The effects of Ramulus et Uncus Uncariae DM fraction on memory enhancing in rats

  • 장현호 (원광대학교 한의과대학 신경정신과학교실) ;
  • 류승준 (원광대학교 한의과대학 신경정신과학교실) ;
  • 한원주 (원광대학교 한의과대학 신경정신과학교실) ;
  • 김경열 (원광대학교 한의과대학 신경정신과학교실) ;
  • 류희영 (춘천한방병원 신경정신과) ;
  • 김태헌 (원광대학교 한의과대학 신경정신과학교실) ;
  • 류영수 (원광대학교 한의과대학 신경정신과학교실) ;
  • 강형원 (원광대학교 한의과대학 신경정신과학교실)
  • Jang, Hyun-Ho (Dept. of Oriental Neuropsychiatry, College of Oriental Medicine, Wonkwang University) ;
  • Lyu, Seung-Jun (Dept. of Oriental Neuropsychiatry, College of Oriental Medicine, Wonkwang University) ;
  • Han, Won-Ju (Dept. of Oriental Neuropsychiatry, College of Oriental Medicine, Wonkwang University) ;
  • Kim, Kyung-Yeol (Dept. of Oriental Neuropsychiatry, College of Oriental Medicine, Wonkwang University) ;
  • Lyu, Heui-Yeong (Dept. of Oriental Neuropsychiatry Medicine, Chuncheon Traditional Medical Hospital) ;
  • Kim, Tae-Heon (Dept. of Oriental Neuropsychiatry, College of Oriental Medicine, Wonkwang University) ;
  • Lyu, Young-Su (Dept. of Oriental Neuropsychiatry, College of Oriental Medicine, Wonkwang University) ;
  • Kang, Hyung-Won (Dept. of Oriental Neuropsychiatry, College of Oriental Medicine, Wonkwang University)
  • 발행 : 2005.06.30
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초록

Objective : The purpose of this study was to estimate the effects of Ramulus et Uncus Uncariae DM fraction on memory enhancing in rats Methods : We oral administered Ramulus et Uncus Uncariae DM fraction to rats then executed passive avoidance test and observed figure of pyramidal neuron on CA1 Results : Findings from our experiments have shown that REUD(>1mg/100g/ml) was effective in memorial improvement. and oral administration of REUD(100mg/100g/ml) for 2 weeks was found to induced the figure of pyramidal neuron on CA1 in rat hippocampus injured by scopolamine. Conclusions : As the result of this study, Decrease of memory induced by injection of scopolamine into rat was also attenuted by REUD, based on passive avoidance test, and REUD was found to reduce the activity of AChE and induced about the CA1 in rat hippocampus. Base on these findings, REUD may be beneficial for the treatment of AD.

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