The Journal of Pediatrics of Korean Medicine (대한한방소아과학회지)
- Volume 19 Issue 2
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- Pages.99-114
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- 2005
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- 1226-8038(pISSN)
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- 2287-9463(eISSN)
The effects of Quibitanggagam(QBT) on the stress due to restraint method in rat
귀비탕가감방(歸脾湯加減方)이 구속 Stress 유발 백서(白鼠)에 미치는 영향
- Kim, Ki-Hyun (Department of Pediatrics, College of Oriental Medicine, Dongguk University) ;
- Chang, Gyu-Tae (Department of Pediatrics, College of Oriental Medicine, Dongguk University) ;
-
Kim, Jang-Hyun
(Department of Pediatrics, College of Oriental Medicine, Dongguk University)
;
- Kwon, Hyuk-Ran (Department of Pediatrics, College of Oriental Medicine, Dongguk University)
- 김기현 (동국대학교 한의과대학 소아과학교실) ;
- 장규태 (동국대학교 한의과대학 소아과학교실) ;
-
김장현
(동국대학교 한의과대학 소아과학교실)
;
- 권혁란 (동국대학교 한의과대학 소아과학교실)
- Published : 2005.12.31
Abstract
Objectives: This study was aimed to find out the anti-stress and protective-memory effect of Quibitanggagam(QBT) on stress of rats Methods : This experimental study was conducted with elevated plus maze test, passive avoidance test, morris water maze test, and consequently density of AchE reactivity in the CA1 of hippocampus to research the learning and memory of rats affected by restraint stress, Results: Passive avoidance test revealed that time latency of retention test for QBT+Stress group significantly decreased on 2, 3rd day. Morris water maze revealed that acqusitive ability of QBT+Stress group significantly improved on 2, 3rd day and retentive ability of QBT+Stress group was significantly improved on 7th day. Elevated plus maze test revealed that latency in open arm of QBT+Stress group significantly decreased and locomotor activity(number of entered arm) of QBT+Stress group was significantly increased. The values of density of AchE stained nuclei in the CA1 of hippocampus QBT+Stress group was significantly increased compared with SAL+Stress group. Conclusion : According to the above results, it is concluded that QBT will be useful as a remedy against stress disease and improving memory.