The Journal of Pediatrics of Korean Medicine (대한한방소아과학회지)
- Volume 19 Issue 2
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- Pages.13-30
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- 2005
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- 1226-8038(pISSN)
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- 2287-9463(eISSN)
A Comparative Study of Regulatory Effect of Atopic Allergic Reaction by Prescriptions (A, B)
당귀음자(當歸飮子) 가감방(加減方)의 처방별 (A, B) 아토피성 알레르기반응 조절 효과 비교 연구
- Park, Eun-Jung (Department of Pediatrics, Jeonju Oriental Hospital, Wonkwang University) ;
- Lee, Hai-Ja (Department of Pediatrics, College of Oriental Medicine, Wonkwang University) ;
- Han, Kyeung-Hoon (Department of Pediatrics, Jeonju Oriental Hospital, Wonkwang University)
- Published : 2005.12.31
Abstract
Objective: Danguieumja-gagambang (DGEJGB), a traditional Korean prescription, has been used as therapeutics for allergic diseases such as atopic dermatitis (AD). In this study, we compared with regulatory Effect of Atopic Allergic Reaction by Prescriptions A and by Prescriptions B. Methods : To evaluate and compare the atopic allergic effectiveness of two prescription (A, B) of DGEJGB, the author investigated a possible effect of DGEJGB on mast cell-mediated allergic reaction, cytokine secretion and mRNA expression in vivo and in vitro. Results : Mast cells are a potent source of mediators that regulate the inflammatory response in allergic reaction. In mice orally administered A, B of DGEJGB ( 0.1, 0.1 and 1.0 g/kg) for 1 h, compound 48/80-induced ear swelling was significantly reduced. Significant reduced levels (P < 0.05). of tumor necrosis factor