The Journal of Pediatrics of Korean Medicine (대한한방소아과학회지)
- Volume 19 Issue 1
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- Pages.67-82
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- 2005
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- 1226-8038(pISSN)
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- 2287-9463(eISSN)
An exprimental Study of the Effects of Yukmijiwhangtanggamibang on Growth, Learning and Memory of Rats
육미지황탕가미방(六味地黃湯加味方)이 흰쥐의 성장(成長)과 학습(學習) 및 기억(記憶)에 미치는 영향(影響)
- Koo, Jin-Suk (Department of Pediatrics, College of Oriental Medicine, Dongguk University) ;
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Kim, Jang-Hyun
(Department of Pediatrics, College of Oriental Medicine, Dongguk University)
- Published : 2005.08.31
Abstract
Objectives : This study was conducted to find out the effect of Yukmijiwhangtanggamibang (YM) on growth, learning and memory of rats. Methods : It was divided SD rats into Sham group, 192 Saporin injection(SA+Saline) group and Injection of 192 Saporin with YM(SA+YM) group. Growth measure length of bone and tail. Memory performance was used aquisition test and learning retention of morris water maze. It was detected acetylcholinesterase(AChE), cholineacetyltransferase(ChAT) at medial septum and hippocampus by immunohistochemistry Results : Body Weight of the SA+YM Group increased effectively, as compared with SA Saline group. Growth of bone in the SA+YM Group increased effectively, as compared with SA+Saline group. Growth of Tail in the SA+YM Group increased effectively, as compared with SA_Saline group. The SA+YM Group in Aquisition Test improved effectively, as compared with SA+Saline group. The SA+YM Group in Learning Test improved effectively, as compared with SA+Saline group. The numbers of ChAT cells in Medial septum increased effectively, as compared with SA+Saline group. The numbers of ChAT cells in CA1 of Hippocampus increased, but was not effective. Conclusion : These results suggest that YM has an improving effect on the impaired learning through the effects on memory registration and retrieval.
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