The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
권호 표지

Effects of Flos Bombacis Malabarici(FBM) on the Monosodium Urate(MSU)-induced Gout Model in Rats

목면화가 Monosodium Urate로 유발된 백서의 통풍에 미치는 영향

  • Cho, Chung-Sik (Department of Internal Medicine, College of Oriental Medicine, Daejeon University) ;
  • Kim, Cheol-Jung (Department of Internal Medicine, College of Oriental Medicine, Daejeon University) ;
  • Chae, Eun-Young (Department of Internal Medicine, College of Oriental Medicine, Daejeon University)
  • 조충식 (대전대학교 한의과대학 신계내과학 교실) ;
  • 김철중 (대전대학교 한의과대학 신계내과학 교실) ;
  • 채은영 (대전대학교 한의과대학 신계내과학 교실)
  • Published : 2005.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objective: The aim was to identify the inhibitory effects of Flos Bombacis Malabarici(FBM) on Monosodium Urate (MSU)-induced gout in rats. Materials and Methods: After pretreatment of FBM I (50mg/kg), FBM II (125mg/kg) for seven days followed by injection of MSU solution, the various indicators related to gout were measured, such as hematological and serum levels and including joint inflammation. Also, it was investigated whether FBM directly inhibits the activity of xanthine oxidase in vitro. Results: As a result of this study, FBM didn't show the cytotoxicity in Jurkat cells, but it showed significant inhibition of activity of xanthine oxidase in vitro. FBM slightly inhibited joint inflammation induced by MSU though not with statistical significance. FBM partially decreased MSU-induced AST, ALT, BUN, creatinine, WBC, ESR elevation and significantly decreased MSU-induced uric acid in serum. Conclusion: These results suggest that FBM has therapeutic effects that are applicable to prevention and treatment of gout. and should be further investigated.

Keywords