The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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The Effects of Fritillariae Rhizoma on bleomycin- induced lung fibrosis

패모(貝母)가 Bleomycin에 의한 폐섬유화(肺纖維化)에 미치는 영향(影響)

  • Rhee, Hyung-Koo (Division of Respiratory System, Department of Internal Medicine, College of Oriental Medicine, Kyunghee University) ;
  • Jung, Sung-Ki (Division of Respiratory System, Department of Internal Medicine, College of Oriental Medicine, Kyunghee University) ;
  • Jung, Hee-Jae (Division of Respiratory System, Department of Internal Medicine, College of Oriental Medicine, Kyunghee University) ;
  • Lee, Kyu-Sun (Division of Respiratory System, Department of Internal Medicine, College of Oriental Medicine, Kyunghee University)
  • 이형구 (경희대학교 한의과대학 폐계내과교실) ;
  • 정승기 (경희대학교 한의과대학 폐계내과교실) ;
  • 정희재 (경희대학교 한의과대학 폐계내과교실) ;
  • 이규선 (경희대학교 한의과대학 폐계내과교실)
  • Published : 2005.03.30
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Abstract

Background & Objective : Idiopathic Lung Fibrosis(IPF) is chronic fibrotic interstitial pneumonia. The pathogenesis is unclear. Fritillariae Rhizoma is the most commonly used antitussive and expectorant Oriental medicinal herb. The effects of Fritillariae Rhizoma on bleomycin-induced lung fibrosis is here evaluated. Material and Methods : Fritillariae Rhizoma extract was daily given to the normal rats, control(bleomycin) rats and treated(bleomycin and Fritillariae Rhizoma) rats at 9.0 mg per body weight 10g for 14 days. 14 days later, the change in Leukocyte count and percentages were observed, as well as IFN-gamma and 1L-4 in BALF, and the change in Semiqualitative histological index(SHI). Results : Compared to control rats, Fritillariae Rhizoma treated rats showed a lower leukocyte count(P<0.05) lymphocyte, neutrophil percentage, SHI(p<0.05), IFN-gamma and IL-4(p<0.05) in treated rats. Conversely, macrophage percentages went higher(p<0.05) in treated rats. Conclusion : This study supports a role for Fritillariae Rhizoma in reducing the maintaining inflammatory cells and cytokines in rats with bleomycin-induced lung fibrosis and in the reduction of fibrosis tissues. Further research is needed in order to develop an effective treatment for lung fibrosis.

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