The Journal of Internal Korean Medicine (대한한방내과학회지)
- Volume 26 Issue 1
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- Pages.143-155
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- 2005
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- 1226-9174(pISSN)
Effect of Gleditsiae Spina extract on immune cells and cytokines in OVA-induced asthmatic mice
급각자가 천식모델 생쥐의 면역세포 및 사이토카인에 미치는 영향
- Song, Sang-Jin (Division of Respiratory System, Dep. of Internal Medicine College of Oriental Medicine, Daejeon University) ;
- Park, Yang-Chun (Division of Respiratory System, Dep. of Internal Medicine College of Oriental Medicine, Daejeon University)
- Published : 2005.03.30
Abstract
Objective : The purpose of this research is to examine the effects of Gleditsiae Spina (GS) extract on immune cells and cytokines in ovalbumin (OVA)-induced asthmatic mice. Methods : In vivo, C57BL/6 mice were sensitized and handicapped by OVA for 12 weeks. During this experiment, the one group was then treated with GS extract for the later 8 weeks (3 times per week) and analyzed by ELISA, flow cytometer and RT-PCR. Results : In vivo, there were significant decreases in eosinophils, IL-4, IL-5, IL-13, IgE in BALF (bronchoalveolar lavage fluid). However,