대한한방내과학회지 (The Journal of Internal Korean Medicine)
- 제26권1호
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- Pages.12-47
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- 2005
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- 1226-9174(pISSN)
생지황음자가미(生地黃飮子加味)가 Streptozotocin으로 유발된 당뇨생쥐에 미치는 영향(影響)
Effects of Saengjihwangeumja-gami on STZ-induced Diabetic Mice
- Kim, Hee-Chul (Department of Hepatic Internal Medicine, College of Oriental Medicine, Dongshin University) ;
- Choi, Chang-Won (Department of Hepatic Internal Medicine, College of Oriental Medicine, Dongshin University)
- 발행 : 2005.03.30
초록
First, mice were dosed with 50mg/kg of streptozotocin(STZ) twice every 24 hours to cause high blood-sugar. Then, after three days, mice were injected with 100mg/kg of STZ again. Two different dosages of Saengjihwangeumja-gami were given to the experiment groups: SA group, 15mg/kg/day, and SB group, 90mg/kg/day, in order to determine the effects of Saengjihwangeumja-gami, which has been known to be good for DM(Diabetes Mellitus). By observing weight and blood-sugar level changes, blood tolerance, the numerical value of BUN(Blood Urea Nitrogen) and creatinine in blood, and through light-electronicmicroscopic and immunohistologic investigations of pancreas and kidneys, the following results were obtained: 1. The experiment groups showed a high suppressive effect of weight-loss. 2. The experiment groups' blood-sugar and blood tolerance showed an effective lowering of blood-sugar levels. 3. The experiment groups did not show any noticeable change in the numerical value of BUN and creatinine in blood compared with that of the control groups. 4. The experiment groups showed a higher Insulin positive reaction of pancreatic islets
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