Journal of Acupuncture Research

  • 제22권5호
  • /
  • Pages.57-66
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  • 2005
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  • 2586-288X(pISSN)
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  • 2586-2898(eISSN)
대한침구의학회 (Korean Acupuncture & Moxibustion Medicine Society)
권호 표지

급성 췌장염모델에서 전침의 치료효과

Therapeutic Effects of Electroacupuncture on Cholecystokinin-octapeptide-induced Acute Pancreatitis Models

  • 정상수 (원광대학교 한의과대학 심계내과학교실) ;
  • 윤지원 (원광대학교 한의과대학 심계내과학교실) ;
  • 정경아 (원광대학교 한의과대학 심계내과학교실) ;
  • 이종덕 (원광대학교 광주병원 진단방사선학교실) ;
  • 배선준 (연세대학교 마취통증학교실) ;
  • 조장희 (가천 뇌과학연구소) ;
  • 성강경 (원광대학교 한의과대학 심계내과학교실)
  • Cheong, Sang-Su (Dept. of Neuroscience and Internal medicine, College of Oriental Medicine, Wonwang University) ;
  • Yoon, Ji-Won (Dept. of Neuroscience and Internal medicine, College of Oriental Medicine, Wonwang University) ;
  • Jeong, Kyoung-Ah (Dept. of Neuroscience and Internal medicine, College of Oriental Medicine, Wonwang University) ;
  • Lee, Jong-Deok (Dept. of Radiology, Gwang-Ju Hospital, College of Medicine, Wonkwang University) ;
  • Bai, Sun-Joon (Dept. of Anesthesiology, College of Medicine, Yonsei University) ;
  • Cho, Zang-Hee (Gachon Institute of Brain Science) ;
  • Sung, Kang-Kyung (Dept. of Neuroscience and Internal medicine, College of Oriental Medicine, Wonwang University)
  • 발행 : 2005.10.20
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초록

Objectives : We examined the effects of electroacupuncture on the cholecystokinin-octapeptide-induced acute pancreatitis in rats. Methods : Rats were administered with $75{\mu}g/kg$ cholecystokinin-octapeptide subcutaneously three times (1, 3 and 5h after shaving) for 5days. Three days after finishing cholecystokinin-octapeptide administration, high frequency electroacupuncture (100Hz) and low frequency electroacupuncture (2Hz) were applied to acupoint equivalent to ST36 (Zusanli) for 7 days. The author determined the pancreatic weight/body weight ratio, the levels of pancreatic heat shock protein HSP60 and HSP72. The author also assay the secretion of ${\beta}-amylase$, lipase and pro-inflammatory cytokines in serum. Repeated cholecysokinin-octapeptide treatment resulted in the typical laboratory and morphological changes of experimentally induced pancreatitis. Results : Eelectroacupuncture significantly decreased the pancreatic weight/body weight ratio in cholecystokinin-octapeptide-induced acute pancreatitis, increased the pancreatic levels of HSP60 and HSP72, and decreased ${\beta}-amylase$ and lipase levels in cholecystokinin-octapeptide-induced acute pancreatitis. Additionally, the secretion of $Interleukin-1{\beta}$ and tumor necrosis $factor-{\alpha}$ was decreased in the animals treated with electroacupuncture. Conclusion : These results suggest that electroacupuncture may have protective effects against cholecystokinin-octapeptide-induced acute pancreatitis.

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