Journal of Acupuncture Research
- Volume 22 Issue 2
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- Pages.19-32
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- 2005
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- 2586-288X(pISSN)
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- 2586-2898(eISSN)
The Analgesic Effect of Bee Venom Acupuncture and Its Mechanism on the Type II Collagen-Induced Arthritis Rats
- Seo, Byung-Kwan (Department of Acupuncture & Moxibustion, College of Oriental Medicine, Kyung-Hee University) ;
- Baek, Yong-Hyun (Department of Acupuncture & Moxibustion, College of Oriental Medicine, Kyung-Hee University) ;
- Choi, Do-Young (Department of Acupuncture & Moxibustion, College of Oriental Medicine, Kyung-Hee University) ;
- Park, Dong-Suk (Department of Acupuncture & Moxibustion, College of Oriental Medicine, Kyung-Hee University)
- Published : 2005.04.20
Abstract
Objectives : to evaluate the analgesic effect of bee venom acupuncture on Choksamni (ST36) in the collagen-induced arthritis rats and investigate the role played by serotonergic receptor subtypes (5-HT1a, 5-HT2a) in the antinociceptive effect of bee venom acupuncture in a thermal hyperalgesia test Methods : Experiments were performed on 5 week-aged 60 male Sprague-Dawley rats according to National Institute of Health guidelines and the ethical guidelines of the International Association for the Study of Pain (IASP). Arthritis was induced with arthrogenic collagen emulsion (Bovine type II collagen