Cytotoxicity, Antibacterial and Antioxidant Activities of the Prescription Cheongyeolsodokum and Its Constituent Herbs

청열소독음(淸熱消毒飮)과 구성약재의 암세포 독성, 항균 및 항산화 효과

  • Lee, Jin-Tae (Dept. of Cosmeceutical Science, Daegu Haany University) ;
  • Lee, Chang-Eon (Dept. of Cosmeceutical Science, Daegu Haany University) ;
  • Son, Jun-Ho (Dept. of Cosmeceutical Science, Daegu Haany University) ;
  • Lee, Jin-Young (Dept. of Cosmeceutical Science, Daegu Haany University) ;
  • Park, Tae-Soon (Dept. of Cosmeceutical Science, Daegu Haany University) ;
  • Lee, In-Cheol (Dept. of Cosmeceutical Science, Daegu Haany University) ;
  • Song, Mi-Ae (Dept. of Cosmeceutical Science, Daegu Haany University) ;
  • Cheon, Soon-Ju (Dept. of Cosmeceutical Science, Daegu Haany University) ;
  • Jee, Seon-Young (Dept. of Oriental Medicine, Daegu Haany University) ;
  • An, Bong-Jeun (Dept. of Cosmeceutical Science, Daegu Haany University)
  • 이진태 (대구한의대학교 화장품약리학과) ;
  • 이창언 (대구한의대학교 화장품약리학과) ;
  • 손준호 (대구한의대학교 화장품약리학과) ;
  • 이진영 (대구한의대학교 화장품약리학과) ;
  • 박태순 (대구한의대학교 화장품약리학과) ;
  • 이인철 (대구한의대학교 화장품약리학과) ;
  • 송미애 (대구한의대학교 화장품약리학과) ;
  • 천순주 (대구한의대학교 화장품약리학과) ;
  • 지선영 (대구한의대학교 한의학과) ;
  • 안봉전 (대구한의대학교 화장품약리학과)
  • Published : 2005.12.30

Abstract

Objectives : The purpose of this research was physiological activities, cytotoxicity, and antibacterial activities of the Cheongyeolsodokum and its constituent herbs. Methods : Physiological activities, cytotoxicity, and antibacterial activities were examined through the Cheongyeolsodokum and its constituent herbs. Results : In the physiological activities, the electron donating ability(EDA) of the water and ethanol extracts from the Cheongyeolsodokum were over 60% and 80% at 100 ppm, respectively. The EDA of the water and ethanol extract from the Cheongyeolsodokum ingredients were gradually increased as well. Water and ethanol extracts from the Cheongyeolsodokum and its constituent herbs inhibited xanthine oxidase activity, they showed superoxide dismutase(SOD)-like activity. The Cheongyeolsodokum and its constituent herbs inhibited cancer cell growth in a dose-dependant manner. Also, the clear zones against Staphylococcus aureus and S. epidermidis were clear shown at 2.5 and 5 mg/disc. Its constituent herbs showed the clear zone against various bacteria such as Candida albicans, S. aureus, S. epidermidis, and S. mutans were shown at 0.5 and 1mg/disc. Conclusions : We observed physiological activities, cytotoxicity, and antibacterial activities of the Cheongyeolsodokum and its constituent herbs. The results also indicated that water extract and ethanol extract of Cheongyeolsodokum and its constituent herbs can be used as a natural ingredient in food or cosmetic industry.

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