대한본초학회지 (The Korea Journal of Herbology)
- 제20권4호
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- Pages.83-94
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- 2005
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- 1229-1765(pISSN)
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- 2288-7199(eISSN)
파극천(巴戟天)이 좌골신경(坐骨神經) 절단(切斷)으로 유발(誘發)된 ddy 마우스 골다공증(骨多孔症) 모델의 예방효과(豫防效果)에 미치는 영향(影響)
The Effect of Morindae Radix Extracts on the Sciatic Nerve Neurectomized Osteoporotic ddy Mice Model Prevention Effects
- 서부일 (대구한의대학교) ;
- 최홍식 (대구한의대학교) ;
- 김연섭 (경원대학교) ;
- 서영배 (대전대학교) ;
- 강정수 (대전대학교) ;
- 고병섭 (한국한의학연구원) ;
- 김호경 (한국한의학연구원) ;
- 박지하 (대구한의대학교)
- Seo, Bu-Il (College of Oriental Medicine, Daegu Haany University) ;
- Choi, Hong-Sik (College of Oriental Medicine, Daegu Haany University) ;
- Kim, Yeon-Sub (College of Oriental Medicine, Kyungwon University) ;
- Seo, Young-Bae (College of Oriental Medicine, Daejeon Uneversity) ;
- Kang, Jung-Soo (College of Oriental Medicine, Daejeon Uneversity) ;
- Ko, Byung-Sub (Korea Institute of Oriental Medicine) ;
- Kim, Ho-Kyoung (Korea Institute of Oriental Medicine) ;
- Park, Ji-Ha (College of Oriental Medicine, Daegu Haany University)
- 발행 : 2005.12.30
초록
Objectives : The present study attempted to reveal the effects of Morindae Radix extracts on the sciatic nerve neurectomized osteoporotic ddy mice model. Methods : Thickness of hind limbs and their differences, absolute and relative tibia weight and thickness, bone failure load, bone mineral density (BMD), histomorphometrical index, serum osteocalcin level, tibia calcium and phosphorus contents were monitored. Results : In sciatic neurectomized mice, thickness of hind limb, absolute and relative weights, thickness, failure loads, BMD of tibia, trabecular bone volume (TBV), thickness of trabecular bone and cortical bone thickness, length were significantly decreased. However, these changes of those dose-dependently reduced in MR extract-dosing group. Conclusions : it is considered that MR extracts have some favorable effect to prevent, the osteoporosis induced by sciatic neurectomy. However, the exact mechanism and the possibility of MR extract were remains unknown. In addition, the potential toxicity of these MR extracts were also unknown. So the further studies were needed about toxicological and pharmacological aspects.