대한본초학회지 (The Korea Journal of Herbology)

  • 제20권3호
  • /
  • Pages.93-100
  • /
  • 2005
  • /
  • 1229-1765(pISSN)
  • /
  • 2288-7199(eISSN)
대한본초학회 (The Korea Association of Herbology)
권호 표지

패장(敗醬)의 급성 췌장염 억제 효과

Inhibitory Effect of Aacute Pancreatitis by Patriniae Herba

  • 박성주 (원광대학교 한의과대학 본초학교실) ;
  • 정종길 (동신대학교 한의과대학) ;
  • 서상완 (원광대학교 한의과대학 본초학교실) ;
  • 황상욱 (원광대학교 한의과대학 본초학교실) ;
  • 김영우 (원광대학교 한의과대학 본초학교실) ;
  • 송달수 (원광대학교 한의과대학 본초학교실) ;
  • 채영석 (원광대학교 한의과대학 본초학교실) ;
  • 신민교 (원광대학교 한의과대학 본초학교실) ;
  • 송호준 (원광대학교 한의과대학 본초학교실)
  • Park, Sung-Joo (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Jeong, Jong-Gil (Dept. of Prescriptions, College of Oriental Medicine Dongshin University) ;
  • Seo, Sang-Wan (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Hwang, Sang-Wook (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Kim, Yong-Woo (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Song, Dal-Soo (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Chae, Young-Seok (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Shin, Min-Kyo (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Song, Ho-Joon (Dept. of Herbology, College of Oriental Medicine, Wonkwang University)
  • 발행 : 2005.09.30
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초록

Objective : Patriniae Herba (PH) has long been used as a remedy for treating infectious diseases in Korea. In the present experiments, the author examined the effects of PH on the cholecystokinin-octapeptide (CCK)-induced acute pancreatitis (AP) in rats. Methods : Male Wistar rat weighing 200 to 250 g were divided into three groups. Normal untreated group, in treatment with PH group; PH (1g/kg) was administered orally, followed by $75\;{\mu}g/kg$ CCK subcutaneously three times, after 1, 3 and 5 h. This whole procedure was repeated for 5 days. In treatment with saline group, the protocol was the same as in treatment group with PH. The author determined the pancreatic weight/body weight ratio, the levels of pancreatic HSP60, HSP72 and the secretion of pro-inflammatory cytokines. Methods : Repeated CCK treatment resulted in the typical laboratory and morphological changes of experimentally induced pancreatitis. PH was significantly decreased the pancreatic weight/body weight ratio in CCK-induced AP. Futhermore, the author demonstrated that PH increased HSP60 and HSP72 compared with CCK-induced AP. Additionally, the secretion of $TNF-{\alpha},\;IL-1{\beta}$ and IL-6 the levels of amylase and lipase were lower than that saline. Conclusions : These results suggest that PH may has a inhibitory effect against CCK-induced AP.

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